Bupivacaine liposome Pregnancy and Breastfeeding Warnings

Bupivacaine liposome is also known as: Exparel

Bupivacaine liposome Pregnancy Warnings

Local anesthetics rapidly cross the placenta. Adverse reactions in the mother and/or neonate are dependent upon the route of administration, procedure, and amount of drug used. Toxic reactions may include alterations in the central nervous system, peripheral vascular tone, and cardiac function.

Bupivacaine has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of developmental toxicity at clinically relevant doses. There are no controlled data in human pregnancy. Bupivacaine in only recommended for use during pregnancy when benefit outweighs risk. This recommendation does not exclude the use of bupivacaine at term for obstetrical anesthesia or analgesia.

Bupivacaine liposome Breastfeeding Warnings

Bupivacaine is excreted into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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