Bupivacaine liposome Pregnancy and Breastfeeding Warnings
Bupivacaine liposome is also known as: Exparel
Bupivacaine liposome Pregnancy Warnings
Local anesthetics rapidly cross the placenta. Adverse reactions in the mother and/or neonate are dependent upon the route of administration, procedure, and amount of drug used. Toxic reactions may include alterations in the central nervous system, peripheral vascular tone, and cardiac function.
Bupivacaine has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of developmental toxicity at clinically relevant doses. There are no controlled data in human pregnancy. Bupivacaine in only recommended for use during pregnancy when benefit outweighs risk. This recommendation does not exclude the use of bupivacaine at term for obstetrical anesthesia or analgesia.
Bupivacaine liposome Breastfeeding Warnings
Bupivacaine is excreted into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.