Atenolol Side Effects
Some side effects of atenolol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to atenolol: oral tablet
Other dosage forms:
Along with its needed effects, atenolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking atenolol:More common
- Blurred vision
- cold hands or feet
- difficult or labored breathing
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- shortness of breath
- tightness in chest
- unusual tiredness or weakness
- chest pain or discomfort
- cold sweats
- dizziness or lightheadedness
- fast heartbeat
- leg pain
- noisy breathing
- slow or irregular heartbeat
- sudden shortness of breath or troubled breathing
- Bloody urine
- decreased frequency or amount of urine
- increased blood pressure
- increased thirst
- loss of appetite
- lower back or side pain
- swelling of face, fingers, or lower legs
- weight gain
- Black, tarry stools
- bleeding gums
- blood in urine or stools
- blurred or loss of vision
- bone or joint pain
- disturbed color perception
- double vision
- feeling that others are watching you or controlling your behavior
- feeling that others can hear your thoughts
- feeling, seeing, or hearing things that are not there
- halos around lights
- night blindness
- overbright appearance of lights
- paleness or cold feeling in fingertips and toes
- pinpoint red or purple spots on skin
- severe mood or mental changes
- skin irritation or rash, including rash that looks like psoriasis
- skin rash, hives, or itching
- sore throat
- swollen or painful glands
- tingling or pain in fingers or toes when exposed to cold
- tunnel vision
- unusual behavior
- unusual bleeding or bruising
Get emergency help immediately if any of the following symptoms of overdose occur while taking atenolol:Symptoms of overdose
- cool, pale skin
- dilated neck veins
- extreme fatigue
- increased hunger
- irregular breathing
- slurred speech
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
Some side effects of atenolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- feeling sad or empty
- lack of appetite
- loss of interest or pleasure
- trouble concentrating
- trouble sleeping
- dream activity
- feeling of constant movement of self or surroundings
- sensation of spinning
- Decreased interest in sexual intercourse
- dry mouth
- inability to have or keep an erection
- loss in sexual ability, desire, drive, or performance
- loss of hair, temporary
- pain of penis on erection
For Healthcare Professionals
Applies to atenolol: compounding powder, injectable solution, oral tablet
Cardiovascular side effects occur in less than 3% of patients and include bradycardia, hypotension, precipitation of heart failure, and cold extremities. Less than 1% of patients report flushing symptoms. These side effects may require discontinuation of therapy or dosage reduction. The use of atenolol may be associated with reduced HDL cholesterol and increased total cholesterol. These changes may be deleterious in some patients with heart disease.
Profound hypotension following atenolol administration for malignant hypertension has been reported.
Nervous system side effects such as complaints of sleep disturbances, depression, and headache occur in up to 4% of patients. Nervous system side effects are less common than with some beta-blockers due to the more hydrophilic properties of atenolol. A single case of organic anxiety syndrome has been associated with rapid withdrawal of atenolol therapy.
Neurologic side effects are less common with atenolol than with some other beta-blockers because it is less lipophilic and, therefore, less able to penetrate the central nervous system. At least three cases of acute central nervous system disturbances have been attributed to atenolol therapy. In one case, the ratio of the serum to CSF atenolol levels was 2:1, which is much lower than previously reported ratios of 14:,1 indicating that there was significant CSF penetration.
Gastrointestinal side effects have included diarrhea and nausea in 2% and 4% of patients, respectively. Retroperitoneal fibrosis has rarely been associated with atenolol.
A 68-year-old woman with hypertension developed vomiting, abdominal pain, and progressive renal failure associated with extensive retroperitoneal fibrosis and ureteral obstruction during atenolol therapy. While the patient was also taking oral iron preparations, metoclopramide, and ibuprofen, the authors of this case report implicate atenolol due to previous associations of the retroperitoneal fibrosis with other beta-blockers.
Hypersensitivity reactions are rare.
Hepatic dysfunction has rarely been associated with atenolol.
A single case of reversible liver dysfunction and a single case of cholecystitis have been associated with atenolol. The mechanism of toxicity is not known, and is considered to be idiosyncratic.
A 71-year-old woman with unstable angina developed multiple erythematous, subcutaneous nodules over the metacarpal-phalanx and interphalanx joints of both hands. The patient also developed an increase of CD8+ T lymphocytes (cytotoxic suppressor lymphocytes) and the presence of antinuclear antibodies. The lesions resolved by 90 days after atenolol was withdrawn. Subsequent use of atenolol lead to a similar sequelae.
Dermatologic side effects are rare. A case of septal panniculitis is reported, thought to be due to an immunologic mechanism.
Endocrine side effects including slightly decreased T3 concentrations among patients with hyperthyroidism have been reported, although T4 concentrations were not affected.
Breast pain, swelling, and tenderness developed in a 54-year-old woman after starting therapy with atenolol 25 mg daily. Symptoms resolved following discontinuation of therapy.
In one study, postmenopausal women reported a reduction in libido after receiving atenolol 50 to 100 mg daily.
Genitourinary side effects have included decreased libido and at least one case of breast pain, swelling, and tenderness.
The mechanism by which atenolol induces weight gain is unknown. Some investigators have reported a 4% to 9% reduction in total energy expenditure and a 25% reduction in thermogenic response to food during beta-blocker treatment.
Metabolic side effects have included weight gain.
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