Alupent Side Effects

Generic Name: metaproterenol,metaproterenol

Please note - some side effects for Alupent may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Alupent - for the Consumer

Alupent

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Alupent:

Difficulty sleeping; dizziness; headache; hyperactivity; nausea; nervousness; stomach upset.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; fever, chills, or sore throat; increased difficulty breathing; itching; pounding in the chest; severe or persistent dizziness; swelling; tremors; wheezing; worsened asthma symptoms.

Alupent Aerosol

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Alupent Aerosol:

Cough; difficulty sleeping; dizziness; headache; hyperactivity; nausea; nervousness; stomach upset; throat irritation.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; fever, chills, or sore throat; increased difficulty breathing; itching; numbness of an arm or leg; pounding in the chest; severe or persistent dizziness; sudden, severe headache; swelling; tremors; vision changes; vomiting; wheezing; worsened asthma symptoms.

Alupent Syrup

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Alupent Syrup:

Difficulty sleeping; dizziness; headache; hyperactivity; nausea; nervousness; stomach upset.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; fever, chills, or sore throat; increased difficulty breathing; itching; pounding in the chest; severe or persistent dizziness; swelling; tremors; wheezing; worsened asthma symptoms.

Alupent Side Effects - for the Professional

Alupent

Adverse reactions are similar to those noted with other sympathomimetic agents. The most frequent adverse reaction to Alupent® (metaproterenol sulfate USP) administered by metered-dose inhaler among 251 patients in 90-day controlled clinical trials was nervousness. This was reported in 6.8% of patients. Less frequent adverse experiences, occurring in 1-4% of patients were headache, dizziness, palpitations, gastrointestinal distress, tremor, throat irritation, nausea, vomiting, cough and asthma exacerbation. Tachycardia occurred in less than 1% of patients.

Side Effects by Body System

General

Metaproterenol has been usually well-tolerated and adverse effects that occurred were consistent with its pharmacological activity. Additionally, partial or complete tolerance may develop to these side effects. In general, the severity of these effects are dependent on the dose and the route of administration. Metaproterenol given by metered dose inhaler (MDI) is associated with less systemic effects than administration of higher dosages orally or by nebulizer.

Cardiovascular

Cardiovascular side effects have included palpitations and peripheral vasodilation, commonly resulting in reflex tachycardia. This may be caused by the interaction of metaproterenol with beta-1 and beta-2 receptors. Blood pressure may increase or decrease. Metaproterenol in higher dosages may rarely aggravate angina, myocardial ischemia, or cause atrial or ventricular arrhythmias.

Musculoskeletal

Musculoskeletal side effects have included tremors. Tolerance often develop to the tremorogenic effects following prolonged use of this medication. Severe muscle cramping may occur infrequently.

Metabolic

The hypokalemic effect is due to the stimulation of beta-2 receptors that are linked to sodium-potassium ATPase in skeletal muscles, resulting in an intracellular influx of potassium.

Metabolic side effects have included hypokalemia, hypophosphatemia, hyperglycemia, and elevations in plasma insulin.

Nervous system

Nervous system side effects have included restlessness, nervousness, anxiety, irritability, headache, dizziness, and insomnia.

Other

Other side effects have included the development of tachyphylaxis to the bronchodilating effects of metaproterenol. Although conflicting data exist, complete clinical tolerance has not been observed.

Hypersensitivity

A 25-year-old woman respiratory therapist with a history of an itchy dermatitis on the face, neck, and upper extremities showed a positive reaction to metaproterenol on skin patch testing.

Hypersensitivity side effects have included rare reports of dermatitis.

Respiratory

Respiratory side effects have included pulmonary edema in pregnant patients receiving the drug intravenously.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.