Almotriptan Side Effects

Not all side effects for almotriptan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to almotriptan: oral tablet

In addition to its needed effects, some unwanted effects may be caused by almotriptan. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking almotriptan:

Less common
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • discharge from the eye
  • eye irritation
  • fast, irregular, pounding, or racing heartbeat or pulse
  • itching, redness, or swelling of the skin
  • neck pain or rigid neck
  • redness of inner lining of the eyelid
  • skin rash
  • shortness of breath
  • tightness in the throat
  • Abdominal or stomach cramping or pain
  • black, tarry stools
  • blood in the stools
  • bringing back up of food
  • chest pain, severe
  • cool, pale skin
  • diarrhea
  • difficulty with swallowing
  • earache
  • fainting
  • fever
  • heartburn, repeated
  • increased sweating
  • loss of appetite
  • loss of vision
  • rapid breathing
  • tightness in the chest
  • weight loss

Some of the side effects that can occur with almotriptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Burning, numbness, prickly, or tingling feeling
  • dizziness
  • dry mouth
  • headache
  • nausea
  • sleepiness
Less common
  • Aching, fullness, or tension in the sinuses
  • anxious feeling
  • back pain
  • belching
  • change in sense of taste
  • chills
  • cough producing mucus
  • decreased sensitivity to touch
  • feeling of constant movement of self or surroundings
  • feeling of spinning
  • feeling of warmth or heat
  • flushing or redness of the skin
  • increased sense of hearing
  • indigestion
  • lack or loss of strength
  • muscle aches
  • muscle weakness
  • nosebleed
  • painful menstrual period
  • quivering or trembling
  • restlessness
  • runny or stuffy nose
  • sore throat
  • trouble with sleeping
  • vomiting
  • Abnormal increase in reflexes
  • abnormally increased feeling of mental and physical well-being
  • buzzing or ringing in the ears
  • change in dreams or nightmares
  • change in sense of smell
  • change in sense of touch
  • clumsiness or unsteadiness
  • continuous, uncontrolled, back-and-forth or rolling eye movements
  • cough
  • difficulty in concentrating
  • double vision
  • drooling
  • dry eyes
  • dry throat
  • feeling of pins and needles
  • hoarseness
  • increased sensitivity to sunlight
  • increased thirst
  • loss of voice
  • mental depression
  • muscle stiffness
  • nervousness
  • pain, redness, swelling, or warmth in the joints
  • sneezing
  • stabbing pain

For Healthcare Professionals

Applies to almotriptan: oral tablet


In one study (n=20), significant effects were reported for the maximal change in diastolic blood pressure and for the maximal and mean change in systolic blood pressure.[Ref]

Cardiovascular side effects, some fatal, have occurred following the use of 5-HT1 agonists. These events are extremely rare and most have been reported in patients with risk factors predictive of CAD. Such effects include coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation. Less frequently reported cardiovascular side effects have included vasodilation, palpitations, and tachycardia. Hypertension and syncope have been rarely reported.[Ref]


General side effects have included headache, abdominal pain or cramp, asthenia, chills, back pain, chest pain, neck pain, fatigue, and rigid neck. Fever and photosensitivity reaction have been rarely reported. Sensations of tightness, pain, pressure, and heaviness in the precordium, throat, neck, and jaw have been reported after treatment with almotriptan. (These events were not associated with arrhythmias or ischemic ECG changes in clinical trials.)[Ref]


Gastrointestinal side effects including nausea and dry mouth have been frequently reported. Less frequently reported gastrointestinal side effects have included diarrhea, vomiting, and dyspepsia. Colitis, gastritis, gastroenteritis, esophageal reflux, increased thirst, and increased salivation have been rarely reported.[Ref]


Metabolic side effects reported infrequently have included hyperglycemia and increased serum creatine phosphokinase. Increased gamma glutamyltransferase and hypercholesterolemia have been rarely reported.[Ref]


Musculoskeletal side effects have included myalgia and muscular weakness. Arthralgia, arthritis, and myopathy have been rarely reported.[Ref]

Nervous system

Nervous system side effects frequently reported have included paraesthesia, dizziness, and somnolence. Less frequently reported nervous system side effects have included tremor, vertigo, anxiety, hyperesthesia, restlessness, CNS stimulation, insomnia, and shakiness. Altered dreams, impaired concentration, abnormal coordination, depressive symptoms, euphoria, hyperreflexia, hypertonia, nervousness, neuropathy, nightmares, and nystagmus have been rarely reported.[Ref]


Respiratory side effects including pharyngitis, rhinitis, dyspnea, laryngismus, sinusitis, bronchitis, and epistaxis have been reported infrequently. Hyperventilation, laryngitis, and sneezing have been reported rarely.[Ref]


Dermatologic side effects including diaphoresis, dermatitis, erythema, pruritus, and rash have been infrequently reported.[Ref]


Special sense reactions have included ear pain, conjunctivitis, eye irritation, hyperacusis, and taste alteration. Diplopia, dry eyes, eye pain, otitis media, parosmia, scotoma, and tinnitus have been rarely reported.[Ref]


Genitourinary side effects reported infrequently have included dysmenorrhea.[Ref]


1. Fleishaker JC, McEnroe JD, Azie NE, Francom SF, Carel BJ "Cardiovascular effect of almotriptan in treated hypertensive patients." Clin Pharmacol Ther 71 (2002): 169-75

2. "Product Information. Axert (almotriptan)" Pharmacia and Upjohn, Kalamazoo, MI.

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