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Benzoyl Peroxide

Pronunciation: BEN-zoyl per-OX-ide
Class: Antibiotic agent

Trade Names

- Gel 10%

Benzac AC
- Gel 5%
- Gel 10%

Benzac AC Wash
- Soap 5%
- Soap 10%

Benzac W Wash
- Soap 5%
- Soap 10%

BenzE Foam
- Foam, aerosol 5.3%

BenzE Foam Ultra
- Foam, aerosol 9.8%

- Gel 5.25%

Benzig LS
- Gel 2.75%

Benzig Wash
- Soap 5.25%

BP Cleanser
- Soap 4.25%

BP Wash
- Soap 5.25%
- Soap 7%

- Gel 4%
- Gel 8%
- Cloths 3%
- Cloths 6%
- Cloths 9%

BPO Creamy Wash
- Soap 4%
- Soap 8%

Clean & Clear Continuous
- Cream 10%

Clean & Clear Persa-Gel Max St
- Gel 10%

Clean & Clear Persa-Gel Ex St
- Gel 5%

Clean & Clear Advantage
- Lotion 5%

Clearplex V
- Gel 5%

Clearplex X
- Gel 10%

Clinac BPO
- Gel 7%

- Lotion 3.5%
- Soap 3.5%

Desquam-X Wash
- Soap 5%
- Soap 10%

- Pad 4%
- Pad 8%

Lavoclen Acne Wash
- Soap 4%
- Soap 8%

Lavoclen Creamy Wash
- Soap 4%
- Soap 8%

NeoBenz Micro
- Cream 3.5%
- Cream 5.5%
- Cream 8.5%
- Wash 7%

NeoBenz Micro SD
- Cream 3.5%
- Cream 5.5%
- Cream 8.5%

Neutrogena On-The-Spot
- Gel 2.5%

- Pads 3%
- Pads 6%
- Pads 9%
- Soap 3%
- Soap 6%
- Soap 9%

Pacnex HP
- Pad 7%

Pacnex LP
- Pad 4.25%

Pacnex MX Cleanser
- Soap 4.25%

Pacnex Wash
- Soap 7%

- Liquid 2.5%
- Bar 10%
- Soap 10%

PanOxyl-4 Creamy Wash
- Soap 4%
- Soap 8%

PR Benzoyl Peroxide Wash
- Soap 7%

- Wash 7%
- Foaming Cloths 3%
- Foaming Cloths 6%
- Foaming Cloths 9%

TL BPO MX Cleanser
- Soap 4.25%

- Cloths 3%
- Cloths 6%
- Cloths 9%
- Pads 3%
- Pads 6%
- Pads 9%

Triaz Cleanser
- Lotion 3%
- Lotion 6%
- Lotion 10%

Zaclir Cleansing
- Soap 4%
- Soap 8%

Benoxyl 5% (Canada)
Benoxyl 10% (Canada)
Benoxyl 20% (Canada)
Clindoxyl (Canada)
Panoxyl Antibacterial Acne Creamy Wash (Canada)
Panoxyl Aquagel 2.5% and 5% (Canada)
Panoxyl 5% (Canada)
Panoxyl 5% Wash (Canada)
Panoxyl 10% (Canada)
Panoxyl 15% (Canada)
Panoxyl 20% (Canada)
Solugel 4 (Canada)
Solugel 8 (Canada)


Release of active or free-radical oxygen capable of oxidizing bacterial proteins is suspected.

Slideshow: Acne Advice: Skin Care Solutions For Both Teens and Adults Alike



Absorbed by the skin, where it is metabolized to benzoic acid and excreted as benzoate in the urine.

Indications and Usage

Treatment of mild to moderate acne vulgaris and as an adjunct to antibiotics, retinoic acid, and sulfur- or salicylic acid–containing products in treating more severe cases of acne.


Hypersensitivity to any of the component in these products.

Dosage and Administration

Adults and Children 12 y and older Topical Cleansers

Wash every day or twice daily. Wet skin areas to be treated prior to administration, rinse thoroughly, and pat dry. Control amount of drying or peeling by modifying dose frequency or concentration. Adjust frequency of use to obtain the desired clinical response.

Other dose forms

After cleaning skin, smooth a small amount over the affected area 1 to 3 times daily. Reduce dose frequency or concentration if bothersome dryness or peeling occurs. If excessive stinging or burning occurs after any single application, remove with mild soap and water, and resume use the next day.

General Advice

  • For topical use only. Not for ophthalmic, oral, or intravaginal use.
  • Avoid contact with eyes, eyelids, lips, and mucus membranes.
  • Assess the skin and identify areas where medication is to be applied and areas that should be avoided (severely irritated or sunburned skin).
  • Visible improvement will normally occur by wk 3 with max lesion reduction approximately by wk 8 to 12.
  • Shake aerosol foam before use.
  • For cloths, wet with a little water and work into a full lather. Cleanse face with cloth for 10 to 20 sec. Rinse thoroughly and pat dry.


Store between 59° and 77°F. Do not expose aerosol foam to heat or store at temperatures above 120°F. Discard cloth after each use; do not flush.

Drug Interactions


Concurrent use may cause severe skin irritation.

Adverse Reactions


Excessive drying, manifested by marked peeling, erythema, possible edema, and allergic contact sensitization/dermatitis.



Assess and document skin condition before initial application and periodically throughout treatment. Monitor for side effects, including redness, scaling, dryness, or persistent itching or burning. Inform health care provider if noted and significant. If bothersome dryness or peeling occurs, consider reducing the frequency of application and/or the concentration of the medication.


Category C .




Safety and efficacy not established in children younger than 12 y; safety and efficacy not established for the cloths, Delos , or Triaz .


Benzoyl peroxide is an oxidizing agent and may bleach hair and colored fabric, including carpet.


Cross-sensitization may occur with benzoic acid derivatives (eg, cinnamon, certain topical anesthetics).

External use only

Avoid contact with eyes, eyelids, lips, mucous membranes, and highly inflamed or damaged skin. Rinse with water if accidental contact occurs.


If severe irritation develops, consult health care provider, discontinue use, and institute appropriate therapy. After reaction clears, treatment may often be resumed with less frequent application.

Sun exposure

Avoid unnecessary exposure to sun and use a sunscreen when using this product.



Edema, erythema, excessive scaling.

Patient Information

  • Advise patient that medication is applied topically to skin lesions every day or twice daily.
  • Teach patient with acne proper technique for applying cream, gel, or lotion: wash hands; thoroughly wash and pat dry area(s) to be treated then apply a thin film of cream, gel, or lotion to cover skin areas with acne lesions. Wash hands after applying medication.
  • Caution patient to avoid contact of medication with hair or colored fabrics because bleaching may occur.
  • Instruct patients to avoid concurrent use of topical alcoholic cleansers, tinctures, astringents, abrasives, and peeling agents unless advised by their health care provider.
  • Caution patient not to cover treated areas with bandages or dressings.
  • Warn patient that applying medication more often than prescribed or in excessive quantities will not produce more rapid improvement or better results, but will result in greater side effects such as redness, scaling, and discomfort.
  • Advise patient if an application is missed, not to try to make it up but to return to normal application schedule as soon as possible.
  • Warn patient to avoid contact with the eyes, eyelids, lips, and mucous membranes.
  • Advise patients if cream or gel comes in contact with the eyes, to wash eyes with large amounts of cool water and to contact their health care provider if eye irritation persists.
  • Advise patients that local stinging, burning, tingling, dryness, and redness are the most common side effects and to notify their health care provider if they become bothersome.
  • Advise patients if severe skin reactions occur, to stop using the medication and contact their health care provider.
  • Warn patient to avoid unnecessary exposure to sun and sun lamps while using this medication. Advise patient to use sunscreens and protective clothing over treated areas when exposure cannot be avoided.
  • Advise patients to talk to their health care provider before using any other topical agents (eg, medicated soaps, astringents, cosmetics, or other acne products) on treated skin.
  • Advise patient that follow-up visits to examine the skin lesions may be necessary, and to keep appointments.

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