Iloperidone Dosage

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Psychosis

Iloperidone must be titrated slowly from a low starting dose to avoid orthostatic hypotension due to its alpha-adrenergic blocking properties.

Recommended starting dose: 1 mg twice daily.

Increases to reach the target dose range of 6 to 12 mg twice daily may be made with daily dosage adjustments to 2 mg twice daily, 4 mg twice daily, 6 mg twice daily, 8 mg twice daily, 10 mg twice daily, and 12 mg twice daily on days 2, 3, 4, 5, 6, and 7, respectively.

Efficacy has been demonstrated with iloperidone in a dose range of 6 to 12 mg twice daily.

The maximum recommended dose is 12 mg twice daily (24 mg/day). Iloperidone doses above 24 mg/day have not been systematically evaluated in the clinical trials.

Iloperidone can be administered without regard to meals.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Iloperidone is not recommended for use in patients with hepatic impairment.

Dose Adjustments

Poor metabolizers of CYP450 2D6 have higher exposure to iloperidone compared with extensive metabolizers. Laboratory tests are available to identify CYP450 2D6 poor metabolizers and dosing adjustments should be considered in this group of patients.

Iloperidone dose should be reduced by one-half when administered concomitantly with strong CYP450 2D6 or 3A4 inhibitors. When a CYP450 2D6 or 3A4 inhibitor is withdrawn from combination therapy, iloperidone dose should then be increased to where it was before.

Dosage adjustments are not routinely indicated on the basis of age, gender, race, or renal impairment status.


Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).


Data not available

Other Comments

Prescribers should be mindful of the fact that patients need to be titrated to an effective dose of iloperidone. Thus, control of symptoms may be delayed during the first 1 to 2 weeks of treatment compared to some other antipsychotic drugs that do not require similar titration. Prescribers should also be aware that some adverse effects associated with iloperidone use are dose related.