Fluticasone / Salmeterol Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Chronic Obstructive Pulmonary Disease - Maintenance

For the maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease with chronic bronchitis and/or emphysema and to reduce exacerbations of COPD in patients with a history of exacerbations:

Inhalation powder:
1 inhalation (250 mcg-50 mcg) twice a day (morning and evening, approximately 12 hours apart). This is the only approved dosage for the treatment of COPD associated with chronic bronchitis. Higher doses are not recommended, as no additional improvement in lung function was observed and higher doses of corticosteroids increase the risk of systemic effects.

Usual Adult Dose for Asthma - Maintenance

Inhalation powder:
1 inhalation twice a day (morning and evening, approximately 12 hours apart).

Range: 1 inhalation (100 mcg-50 mcg) twice a day to a maximum of 1 inhalation (500 mcg-50 mcg) twice a day, starting with a dose based on the patient's asthma severity. The maximum recommended dose is 500 mcg-50 mcg twice a day. More than one inhalation twice a day is not recommended.

Inhalation aerosol:
2 inhalations twice daily every day.

Range: 2 inhalations of 45 mcg-21 mcg twice a day to a maximum of 2 inhalations of 230 mcg-21 mcg twice a day, starting with a dose based on the patient's current asthma therapy. The maximum recommended dose is 2 inhalations of 230 mcg-21 mcg twice a day. More than 2 inhalations twice a day is not recommended.

Usual Pediatric Dose for Asthma - Maintenance

4 years to 11 years:
Inhalation powder:
For patients who are symptomatic on an inhaled corticosteroid:
1 inhalation (100 mcg-50 mcg) twice a day (morning and evening, approximately 12 hours apart).

> 12 years:
Inhalation powder:
1 inhalation twice a day twice daily (morning and evening, approximately 12 hours apart).

Range: 1 inhalation (100 mcg-50 mcg) twice a day to a maximum of 1 inhalation (500 mcg-50 mcg) twice a day, starting with a dose based on the patient's asthma severity. The maximum recommended dose is 500 mcg-50 mcg twice a day. More than one inhalation twice a day is not recommended.

Inhalation aerosol:
2 inhalations twice daily every day.

Range: 2 inhalations of 45 mcg-21 mcg twice a day to a maximum of 2 inhalations of 230 mcg-21 mcg twice a day, starting with a dose based on the patient's current asthma therapy. The maximum recommended dose is 2 inhalations of 230 mcg-21 mcg twice a day. More than 2 inhalations twice a day is not recommended.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

The dosage of fluticasone-salmeterol should be adjusted to the lowest effective dosage once asthma stability is achieved.

Precautions

The regular use of beta-2 agonists has been associated with a mild increase in airway responsiveness, a decrease in the bronchoprotective effect, and deterioration in disease control. Patients requiring more than four inhalations of an additional short-acting beta-2 agonist daily should be reevaluated by a physician.

Dialysis

Data not available

Other Comments

Fluticasone-salmeterol requires regular administration to be effective. Fluticasone-salmeterol is not effective when it is used on an "as needed" basis. One to two weeks may be required to achieve maximum benefit. Fluticasone-salmeterol is not intended for the treatment of acute bronchospasm. Patients should be provided with a short-acting beta-2 agonist for the treatment of acute symptoms.

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