Fluticasone / salmeterol Pregnancy and Breastfeeding Warnings

Fluticasone / salmeterol is also known as: Advair Diskus, Advair HFA

Fluticasone / salmeterol Pregnancy Warnings

Fluticasone-salmeterol for inhalation has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity when corticosteroids are administered orally or potent steroids are applied topically. Fluticasone has been shown to be teratogenic when administered subcutaneously at high doses to mice. Animal studies with salmeterol have demonstrated a teratogenic effect when given orally at several times the dosage used clinically. There are no controlled data in human pregnancy. Fluticasone-salmeterol is only recommended for use during pregnancy when benefit outweighs risk.

Fluticasone / salmeterol Breastfeeding Warnings

There are no data on the excretion of fluticasone into human milk. Plasma levels of salmeterol, after inhaled therapeutic doses, are very low. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug the mother.

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