Eslicarbazepine Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Seizures

Initial dose: 400 mg orally once daily for one week, then increase to 800 mg orally once daily
Maintenance dose: 800 mg orally once daily and some patients may benefit from a maintenance dose of 1200 mg orally once daily (although the 1200 mg dosage is associated with increased adverse reactions)
Maximum dose: 1200 mg orally daily

Comments:
A maximum dose of 1200 mg daily should only be initiated after the patient has tolerated 800 mg daily for at least a week. For some patients, treatment may be initiated at 800 mg once daily if the need for additional seizure reduction outweighs an increased risk of adverse reactions.

Approved indication: As adjunctive treatment of partial-onset seizures

Renal Dose Adjustments

Moderate to severe renal impairment (CrCl less than 50 mL/min): Initiate dosing at 200 mg orally once daily for 2 weeks, and then increase to 400 mg orally once daily for maintenance. Some patients may benefit from the maximum recommended maintenance dosage of 600 mg orally once daily.

Liver Dose Adjustments

Mild to moderate liver impairment: No adjustment recommended
Severe liver impairment: Data not available

Dose Adjustments

Eslicarbazepine dosage should be reduced gradually to minimize the risk of increased seizure frequency and status epilepticus.

Carbamazepine reduces the plasma concentration of eslicarbazepine. When eslicarbazepine and carbamazepine are taken concomitantly, the dose of eslicarbazepine or carbamazepine may need to be adjusted based on efficacy and tolerability.

For patients taking other enzyme-inducing antiepileptic drugs (AEDs) (i.e., phenobarbital, phenytoin, and primidone), higher doses of eslicarbazepine may be needed.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Standard hemodialysis procedures result in partial clearance of eslicarbazepine.

Other Comments

Eslicarbazepine tablets may be swallowed whole or crushed.

Eslicarbazepine may be taken without regard to meals.

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