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Eslicarbazepine Dosage

Applies to the following strength(s): 200 mg ; 400 mg ; 600 mg ; 800 mg

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Seizures

Initial dose: 400 mg orally once a day for one week, then increase to 800 mg orally once a day
Maintenance dose: 800 mg orally once a day (some patients may benefit from a maintenance dose of 1200 mg orally once a day although the 1200 mg dosage is associated with increased adverse reactions)
Maximum dose: 1200 mg orally once a day

-This drug may be taken without regard to meals.
-Tablets may be swallowed whole or crushed.
-A maximum dose of 1200 mg daily should only be initiated after the patient has tolerated 800 mg daily for at least a week.
-For some patients, treatment may be initiated at 800 mg once daily if the need for additional seizure reduction outweighs an increased risk of adverse reactions.
-This drug should not be taken as an adjunctive therapy with oxcarbazepine.

Approved indication: As adjunctive treatment of partial-onset seizures with or without secondary generalization

Renal Dose Adjustments

-CrCl greater than 60 mL/min: No adjustment recommended
-CrCl 30 to 60 mL/min: 200 mg orally once a day; after 2 weeks, dosage may be increased to 400 mg orally once per day, which is the recommended maintenance dose; some patients may benefit from the maximum recommended maintenance dose of 600 mg orally per day
-CrCl less than 30 mL/min: Use is not recommended

Liver Dose Adjustments

-Mild to moderate liver dysfunction: No adjustment recommended
-Severe liver dysfunction: Use is not recommended

Dose Adjustments

-This drug should be added to existing anticonvulsant therapy.
-The dosage should be reduced gradually to minimize the risk of increased seizure frequency and status epilepticus.
-Carbamazepine reduces the plasma concentration of this drug. When this drug and carbamazepine are taken concomitantly, the dose of one of the two drugs may need to be adjusted based on efficacy and tolerability.
-For patients taking other enzyme-inducing antiepileptic drugs (AEDs) (i.e., phenobarbital, phenytoin, primidone), higher doses of this drug may be needed.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Hemodialysis removes metabolites from plasma

Other Comments

Administration advice:
-This drug may be taken without regard to meals.
-Tablets may be swallowed whole, divided, or crushed.