Amlodipine / Hydrochlorothiazide / Valsartan Dosage
This dosage information may not include all the information needed to use Amlodipine / Hydrochlorothiazide / Valsartan safely and effectively. See additional information for Amlodipine / Hydrochlorothiazide / Valsartan.
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: Individualize based on the effectiveness and tolerance of each individual component, orally once daily.
Maintenance dose: Individualize based on the effectiveness and tolerance of each individual component, orally once daily. The dosage may be increased after two weeks of therapy. The full blood pressure lowering effect was achieved two weeks after being on the maximal dose.
Maximum dose: Amlodipine/hydrochlorothiazide/valsartan 10/25/320 mg orally once daily
Renal Dose Adjustments
CrCl 30 mL/min or less: Not recommended
CrCl 30 mL/min or more: No adjustment recommended
Liver Dose Adjustments
Mild-to-moderate hepatic impairment: When administering amlodipine/hydrochlorothiazide/valsartan to patients with mild-to-moderate hepatic impairment, including patients with biliary obstructive disorders, monitor for worsening hepatic or renal function, including fluid status and electrolytes, and adverse reactions.
Severe hepatic impairment: Amlodipine/hydrochlorothiazide/valsartan should be avoided in patients with severe hepatic impairment or progressive liver disease, because minor alterations of fluid and electrolyte balance, such as those resulting from diuretic use, may precipitate hepatic coma.
The full blood pressure lowering effect of amlodipine/hydrochlorothiazide/valsartan is achieved after 2 weeks of therapy on the maximal dose.
Amlodipine/hydrochlorothiazide/valsartan may be substituted for its individually titrated components for patients on amlodipine, valsartan, and hydrochlorothiazide.
No initial dosage adjustment of amlodipine/hydrochlorothiazide/valsartan is necessary for elderly patients.
Caution should be exercised when initiating therapy or increasing the dosage of amlodipine/hydrochlorothiazide/valsartan to avoid increased side effects.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Limited data suggest amlodipine/hydrochlorothiazide/valsartan is only minimally removed by hemodialysis, if at all.
Amlodipine/hydrochlorothiazide/valsartan may be used as add-on/switch therapy for patients not adequately controlled on any two of the following antihypertensive classes: calcium channel blockers, angiotensin receptor blockers, and diuretics.
A patient who experiences dose-limiting adverse reactions to an individual component of amlodipine/hydrochlorothiazide/valsartan may be switched to a lower dose of that component to achieve similar blood pressure reductions.
Amlodipine/hydrochlorothiazide/valsartan may be taken without regard to food.