Also known as: Folex PFS, Methotrexate LPF Sodium, Otrexup, Rheumatrex Dose Pack, Trexall
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
methotrexate for Rheumatoid Arthritis: I've had rheumatoid arthritis (RA) for 35 years. I finally found a rheumatologist that was very good. I started on Plaquenil, which was great, but I developed an allergy to it. Switched to methotrexate oral, but had a hard time tolerating the nausea and diarrhea. Switched to injectable methotrexate, and had no nausea, limited diarrhea. It worked moderately well for the RA. Not completely pain free, but could do most things most days. I got cellulitis while on it, so had to go off for about 3 mos. When I went back to it, it didn't seem to work quite as well, and I realized I was experiencing more side effects than I was aware of the first time: thin skin, dermatitis, bruising, bleeding, hair falling out. New rheumatologist (my good one moved) decided to try Arava.
methotrexate for Psoriasis: Tried all other methods for relief of psoriasis, 80% of body.
Have been on methotrexate for 5.5 weeks, belly, back, chest and forearms are all clear, very mild psoriasis that isn't red or irritated on upper arms and lower legs.
My confidence and self esteem has increased heaps, excited to go for a swim 2nd time since I've had psoriasis (7 years). Only had bad fatigue for first few weeks, haven't drank any alcohol, healthy diet with minimal junk food, and nausea if I eat something really, fatty eg. pizza.
Skin colour isn't yellowing nor getting black under the eyes, or anything else relating to bad liver.
Would definitely recommend this medication.
24 users found this comment helpful.
Review by scaly girl (taken for less than 1 month):
methotrexate for Psoriasis: I have had psoriasis on my scalp since I was a baby with "Cradle Cap.'' It was left untreated until I was about 21. I have tried every cream and t-gel out there. Nothing cleared it up fully. Since I turned 24 the condition has spread to other parts of my body, usually parts that don%u2019t get much light. Psoriasis is terrible and affects everyone so differently. This condition has kept me from getting close to people and even kept me from going to hair dressers. Finally I decided to start this medicine. I'm currently on my fourth week of 15mg oral methotrexate. I have noticed a huge decrease in itching and my patches seem to be not as scaly. I really hope this works, so far so good.
12 users found this comment helpful.
methotrexate for Psoriasis: This drug greatly helped my psoriatic arthritis, but not the plaque poriasis, which always came back. I've been through the scrip topicals, light treatments, Amiveve, etc. I was 98% covered. Why did not a single doctor ever tell me NOT to touch beer???? If you drink beer put it DOWN and see how quickly you begin to clear up. Pork is another culprit as it is slow to digest and effects the immune system. For topical relief? Try OTC Boudreaux's Butt Paste baby diaper rash cream, which far outshines Dovonex. Scalp treatment? Nutrogena T-Gel Shampoo works quickly. If you are severely covered add zinc or zinc supplements to your diet. I haven't gone to a derm in years and I am clear!!!!
15 users found this comment helpful.
methotrexate for Psoriasis: I have had psoriasis since I can remember, last year after a foot injury I developed psoriatic arthritis. Since it has spread to both feet, both knees, one hand and lower back. Leaving me hardly being able to walk at 30. I started methotrexate 4 weeks ago and it is helping a lot. Only side effects for me are fatigue.
I do 1 ml injections once a week. If you have PsA, get on methotrexate. If you can handle the needles injections are the way to go.
Review by MoneyMan (taken for 6 months to 1 year):
methotrexate for Psoriatic Arthritis: I have been using 20 mg for over a year with few side effects. It didn't take away pain and stiffness 100%, so my doctor included Humira. With both meds I am virtually pain free, stiffness and inflamation gone. Before I began treatment, I couldn't tie my shoes, write a letter, or open a jar. Now all of those activities are effortless.
Review by Arouran Moon (taken for less than 1 month):
methotrexate for Psoriasis: Started taking methotrexate approx. 1 and a 1/2 weeks ago. Already have seen significant improvements. I have had over 75% coverage of psoriasis from head to toe since my teens and I am now 45. Minor troubling side effect include slight nausea, bad fatigue and dizziness. These clear up after I finish my three day treatment. Positive outweighs the negative. I am scheduled for my first liver test on Oct 1st. In my opinion ...worth it!
21 users found this comment helpful.
methotrexate for Psoriasis: During the Christchurch earthquakes my mother (who's had psoriasis all her life) and myself broke out big time. We found a specialist and got put on this. It cleared up in a matter on 2 weeks for mum, for me it was 3-4 weeks. We both have had no side effects. However, now 1 yr later after moving to Auckland I can't find a doctor who will supply it to me. One week from being off it and has all come back. Just want to be a normal 20 yr old. If you got a doctor who prescribes this, don't let them go.
13 users found this comment helpful.
methotrexate for Psoriasis: I am just diagnosed with psoriasis on May 2013 and I am on my 3rd week of methotrexate and so far it cleared the psoriasis on my neck and under my breast. It stops the wetness and flakes and the ones in my arm and tummy are lesser in flakes. I just hope that my dermatologist will allow me to continue the medicine, but it depends on the lab results on my liver.
14 users found this comment helpful.
methotrexate for Psoriasis: I have been suffering with psoriasis for 4 years now and with each year it keeps on getting worse. The guttate psoriasis covers 80% of my body. I have tried ointments, light therapy and now methotrexate. All treatments work for a while but oddly enough the psoriasis comes back with vengeance. New spots appear. My dermatologist explained to me that it takes 3 months for methotrexate to work. It slightly cleared up my Psoriasis the first month but on the third month my psoriasis came back even worse. I'm glad to read that this medicine has done wonders for many but it just didn't work for me.
19 users found this comment helpful.
methotrexate for Rheumatoid Arthritis: I have taken methotrexate for 17 years and am now on 20mg per week. I have also been on Rituximab infusions for the past 3 years and together the two medicines work very well. I am mostly pain free, except for mornings.
26 users found this comment helpful.
methotrexate for Psoriasis: Just started a week ago. Was nervous regarding side effects but bit the nerves. Notice there is no flaking after one week. Although still itchy hopefully that goes away. Just felt like I was exhausted faster but want to keep giving it a try. Tried everything else.
14 users found this comment helpful.
methotrexate for Psoriatic Arthritis: I've been on methotrexate for 3 years at 8 tablets (2.5 mgs). For some reason I only have psoriasis on my hands and then only my thumbs and the center of my inside right hand. That has cleared up considerably to where it is no problem. Thank goodness I have not got it anywhere else. I noticed that my knees, which had been painful, stopped hurting entirely after about six months. Before it was quite painful... now I have no pain. I haven't been taking the folic acid like I should.
11 users found this comment helpful.
Review by fluffynut (taken for 6 months to 1 year):
methotrexate for Psoriasis: I've had severe psoriasis which covered me head to toe since I was 5 I'm now 30. Tried every trick in the book from lotions and potions, light therapy & homeopathic remedies. I put off taking methotrexate for fear of becoming a glow in the dark alien with the side effects! Finally gave in last year and so glad I did. It cleared within 3 weeks. I'm now on 15mg a week and only have slight patches of psoriasis dotted about. Had a few bad headaches now and then but nothing extreme. A little wobbly on the blood tests but nothing life threatening just yet. Much better quality of life at the min, and much less hoovering haha.
45 users found this comment helpful.
methotrexate for Psoriasis: My mother broke out seemed like overnight with red bumps that quickly turned into dry patches. The dermatologist knew right away what it was. We have been on the Methotrexate for 6 weeks and the flaking is totally gone and is healing. The dose was 2 Friday morning, 2 Friday evening and 2 Saturday morning. Only side effect was appetite and very tired for 2 days.
23 users found this comment helpful.
methotrexate for Eczema: After suffering from about 5 years old, I'm now 56. Only been on the medication for approx 9 weeks the improvement has been amazing. I've been unable to cope with the pain and spent many days in bed over the years so touch wood this medication will keep on working.
methotrexate for Psoriasis: I have been on methotrexate for 2 1/2 years, I cleared up within 2 months and have stayed cleared up! Knowing you can only have so many grams in a certain amount of time makes me sad because soon I will have to stop taking it and switch to something different. I am 39 and have had psoriasis since I was 21. I can wear shorts and a t-shirt and feel normal. Methotrexate has given me my freedom back and I have had no side effects. If you have psoriasis you should give it a try, for me it's been so worth it.
65 users found this comment helpful.
Review by Big Momma 2012 (taken for 1 to 6 months):
methotrexate for Rheumatoid Arthritis: After many years of joint pain, finally found a physician who looked at x-rays, labs, family history, my entire medical history and determined that I indeed had Rheumatiod Arthritis. I have noticed a significant change after being put on Methotrexate, Prednisone, Folic Acid, and Tramadol. However, now that winter is here, joints are worse and I am now on the highest dose of Methotrexate (20mg) a week but I'm able to get out and do more with less pain than before.
47 users found this comment helpful.
Rheumatrex Dose Pack (methotrexate) for Rheumatoid Arthritis: Took methotrexate for 6 months after diagnosis for Rheumatoid arthritis, seemed to work fairly well for the pain/stiffness, but I had terrible side effects including nausea, fatigue, mood swings - almost couldn't get to work, coming up stairs felt like my feet weighed 500 pounds each - almost could not function at all. Now going to try in injectable form to see if that will not cause the side effects - hopeful.
42 users found this comment helpful.
methotrexate for Rheumatoid Arthritis: I am female, 41, have been taking methotrexate for 2 months now. I was crippled, my hands fingers wrists ankles balls of my feet knees shoulders arms even my jaw. I could barely walk I couldn't unscrew lids, peel potatoes, do everyday chores people take for granted. My rheumatoid factor was 1380. After 1 month no change hopefully my 2nd reading it will come down. Anyway after 1 month on the medication my joint pains has disappeared thanks to Methotrexate. I take 10mg once weekly with folic acid next day. Worked for me. YAY!
44 users found this comment helpful.
methotrexate for Rheumatoid Arthritis: I have only been taking this medicine for a short while and the benefits are good so far. I am still able to keep working as a Paramedic which is physically demanding. Without my 20mg I slowly turn into a statue.
29 users found this comment helpful.
Review by Anonymous (taken for 6 months to 1 year):
methotrexate for Psoriasis: It works great! I have had Psoriasis all my adult life and only two things have worked. The first was the original Skin Cap spray from Spain but that disappeared after the U.S. government got involved. This was second. I have been on methrotrexate 2.5mg tablets for 6 months and was fully clear within the first month. No stomach problems and no other side effects. If you suffer from psoriasis, do yourself a favor and find a doctor that will work with you to try it.
38 users found this comment helpful.
methotrexate for Rheumatoid Arthritis: I have been taking the medication sine June 2011 I like it, but I'm always sick. It minimizes the pain and swelling, but it doesn't take it all away. I wake up every morning, and I can hardly move my ankles. I'm way to young to have to deal with this I'm only 22 years old. Some days I feel like I'm suffering, and if I'm sick I can't even walk.
33 users found this comment helpful.
methotrexate for Psoriatic Arthritis: Been on methotrexate for a few years, started with one pill than nine pills. Now I do injection 25mg weekly for about a year now. I know there is no cure and I am thankful this medicine has made it possible to chase grandson around daily.
25 users found this comment helpful.
methotrexate for Systemic Sclerosis: My daughter age 10 has this disease. She has been on methotrexate for almost a year. She started out 0.6mg now 10 plus Solu-Medrol infusions to stop or slow the process, suppress it I know it is helping to slow it down cause it is getting a bit worse. She has blood tests done monthly and when they raise her dose her blood gets tested in 2 weeks. We noticed this disease at age 3.
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