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User Reviews for Methotrexate

Also known as: Folex PFS, Methotrexate LPF Sodium, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Methotrexate.

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29%(11)
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21%(8)
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24%(9)
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8%(3)
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8%(3)
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Methotrexate Review Summary

8.0/10 Average Rating

39 Ratings with 35 User Reviews

What next?Compare all 322 medications used in the treatment of Rheumatoid Arthritis.

Reviews for Methotrexate to treat Rheumatoid Arthritis

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"I took Methotrexate for 17 years. Started with tablets but progressed to injections for less chance of side effects (and cheaper!). Always felt tired and nauseous for a day after, which got worse and lasted longer over the years, so that instead of just folic acid, my rheum had me take leucovorin the day after (a stronger folic acid). But 6 months ago I developed fatigue, malaise and chronic low grade fever despite normal blood tests; my rheum said he had seen that before in other patients taking Methotrexate and considered it a toxic reaction! There is no literature on this reaction, but I got better once I stopped, so just be aware."

   
5.0

CCEA August 13, 2015

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"When all other meds/combo of meds failed my rheumy put me on mtx (8 tabs@ 2.5 mg. once a week). I still take 4 mg prednisone twice a day, 400 mg of plaquenil at night, and folic acid every morning. It's been a long road and a lot of ups and downs but I have seen the most progress since mtx was added to my combo of meds. I still have some pain but the stiffness (which used to last most of the day) and the swelling has improved. I am always nauseous and feel lethargic the first 24 - 48 hours after the mtx dose but 1-2 days of that is better than the alternative. I've always been extremely active so it has been rough struggling to do simple things."

   
10

Annie M (taken for 1 to 6 months) July 31, 2015

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"I got my RA seven years ago and have eaten Mtx since then. For me it has worked great. I had no weird side effects either. I ate 8 tablets a week for seven years, but now I'm down to 6 tablets .... it works great too. I am Swedish, and our Mtx looks a bit different."

   
10

MisoPretty July 19, 2015

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"I was diagnosed at 10mths old after a knee biopsy. I have been taking methotrexate on & off since I was 16 years old & I am now 41 years old. This medication has greatly reduce the activity of the disease & has increased the quality of my life greatly. I have just changed from methotrexate oral tablets to methotrexate injections. The tablets were making me feel nauseous so my specialist decided to put me on injections to bypass my stomach. The injections are easy to administer & relatively pain free. I am presently just trying to find the right dose for me due to suffering side effects. 15mg has caused me a severely sore lips & mouth, nausea, dizziness, lethargy & abdominal cramps. 12.5mg is the correct dose for me."

   
8.0

Sharrona July 19, 2015

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"Started mtx in early 2010, I was on it the better part of the last 5 years. I'm also on my fourth biologic. I take 2mg of folic acid daily. Last May I did a four day stretch in hospital because of bone marrow suppression. RBC, WBC, ANC, platelets and hemoglobin were very low. (ANC under 200). I was given leucorvorin rescue. This is a very rare side effect for low dose mtx. Although the drug only gave me a 10 to 20% improvement, the biologic gives me 60 to 90%. Now I'm about to start Arava, I wish I could retry the mtx at half dose as it doesn't cause much in the way of minor side effects. I often think of Huey Lewis and his song "I want a new drug"."

   
5.0

RheumTrucker (taken for 5 to 10 years) July 2, 2015

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"I have been on this medication for about 2 months now. I was taking prednisone before but that wouldn't help much. After the second week of taking methotrexate I can honestly say I am pain free. I can actually enjoy doing all the stuff I used to do before being diagnosed with RA. Before starting this medication I would experience horrible pain in my shoulders, hands, fingers, hips and ankles. I would have a rough time getting through the day. This medication works wonderfully."

   
10

Anonymous (taken for 1 to 6 months) June 5, 2015

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"I have been on Methotrexate 25mg for 6 weeks now, but 6 month for 20 mg and I have seen much improvement with my back pain. I do have severe rib and chest pain still, but the back pain is much better. I feel like a zombie though every day I can barely make it through the day. I am so upset about my hair. I have cut almost 6 inches off and still have dry damaged hair from the medicine. I loose handfuls of hair daily and the gi problems sometimes are pretty bad. So I don't know if the side effects out way the benefits. I wish I could have someone help Me fix these side effects and I would be ok. I think the fatigued is one of the worse though. :( ...."

   
7.0

Jenn Jenn June 2, 2015

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"I'm on my 3rd month and I do believe it's helping but the pain is still there. I have noticed as the dosage has increased it takes longer to bounce back and I'm unable to cut hair as that was my profession before diagnosis. I hope in time I will be able to get back to work but I am suffering several side effects. (hair falling out, unusually dry hair, quick to have to rest unlike before and several others) I was completely bed ridden before starting the medication so needless to say I don't want to try anything else because I am scared to take the chance that it won't work at all. I know I'm just beginning and hope in time the side effects will fade."

   
8.0

Jenni bug April 2, 2015

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"A couple of years ago my husband was at the point where he was limping severely, with swollen joints in his hands and feet. He was diagnosed with rheumatoid arthritis and began taking methotrexate at 20 mg once a week; he has since cut back to 17.5 mg. It has made a huge difference in his functioning, and he's pretty much back to normal. (Regular strength training at the YMCA has also helped a lot). He was also told to take folic acid once a day, which he does. The only negative is that his hair has thinned quite a bit, which is a common side effect. He is in his 70s."

   
10

AnonCat March 19, 2015

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"I have only been taking the Methotrexate since the end of September and I am on 25mg per week. I was also prescribed the Folic Acid but can't take that as it causes such an upset stomach that I stopped it all together. So far the only symptoms I have had were in the beginning and that was feeling nausea, and very tired the day after taking it. It has helped with the swelling and pain and I have no pain in my knees anymore and just a bit in the hands, wrists and my one foot."

   
8.0

Cocacolababy (taken for 1 to 6 months) November 22, 2014

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"Just taken my third dose of methotrexate this week (upped to 20mg after 2 weeks on 10mg)....take folic acid 5mg 3 x week. So far side effects have been manageable. Not sure if it's the medication or the steroid injections but I am starting to feel like my old self again. No swelling and little pain now so am now able to do the things I used to take for granted again. Feel hopeful about this medicine."

   
8.0

Dormouse (taken for less than 1 month) October 4, 2014

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"I have been taking methotrexate for two weeks now. Before taking this, I had pain in my hips, knees, ankle and could not walk on the heel of one of my feet. The pain was really bad. I am now walking on my foot again with little pain and do not feel so fatigued and tired, I do feel tired and a bit dizzy for a few days after the medication but not too bad. I am only taking 3 a week at moment, and about to take four, then five and six. Hopefully I wont have to many side affects."

   
7.0

maseymae (taken for less than 1 month) July 29, 2014

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"I have been on methotrexate for almost a year. I am up to 20 mg a week. I take folic acid and leucovorin calcium 12 hours after the methotrexate. I was taking Enbrel but now take Xeljanz. Before the biologics the methotrexate wasn't working very well. I take prednisone too. I am only 36 but at least I can function better than I did. I still flare about twice a month. I suffer side effects from methotrexate. My hair has severely thinned out and I get very tired after taking it. It looks like I'll be on it for a long time tho. Hopefully it gets better. I would really Like my hair to come back."

   
6.0

ACS3 July 5, 2014

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"I have been on methotrexate for two months now and have slowly increased my dose to 17.5mg/week. I started on a daily dose of folic acid but switched to a weekly dose of Leucovorin due to dizziness a couple of days after my Methotrexate dose. My pain and inflammation are gone and I feel so much better. I am once again able to do the things I love and have no side effects. I'm RF negative, but my rheumatologist chose to treat me quickly and aggressively based on symptoms and a high CCP. I'm thankful she did. I hope Methotrexate will be a long term solution to treat my rheumatoid arthritis."

   
10

Dpalmer63 (taken for 1 to 6 months) July 1, 2014

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"I've had rheumatoid arthritis (RA) for 35 years. I finally found a rheumatologist that was very good. I started on Plaquenil, which was great, but I developed an allergy to it. Switched to methotrexate oral, but had a hard time tolerating the nausea and diarrhea. Switched to injectable methotrexate, and had no nausea, limited diarrhea. It worked moderately well for the RA. Not completely pain free, but could do most things most days. I got cellulitis while on it, so had to go off for about 3 mos. When I went back to it, it didn't seem to work quite as well, and I realized I was experiencing more side effects than I was aware of the first time: thin skin, dermatitis, bruising, bleeding, hair falling out. New rheumatologist (my good one moved) decided to try Arava."

   
6.0

kpalchk (taken for 1 to 2 years) January 9, 2014

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"I have taken methotrexate for 17 years and am now on 20mg per week. I have also been on Rituximab infusions for the past 3 years and together the two medicines work very well. I am mostly pain free, except for mornings."

   
8.0

Nakuru5 July 1, 2013

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"After many years of joint pain, finally found a physician who looked at x-rays, labs, family history, my entire medical history and determined that I indeed had Rheumatiod Arthritis. I have noticed a significant change after being put on Methotrexate, Prednisone, Folic Acid, and Tramadol. However, now that winter is here, joints are worse and I am now on the highest dose of Methotrexate (20mg) a week but I'm able to get out and do more with less pain than before."

   
8.0

Big Momma 2012 (taken for 1 to 6 months) November 7, 2012

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Rheumatrex Dose Pack (methotrexate): "Took methotrexate for 6 months after diagnosis for Rheumatoid arthritis, seemed to work fairly well for the pain/stiffness, but I had terrible side effects including nausea, fatigue, mood swings - almost couldn't get to work, coming up stairs felt like my feet weighed 500 pounds each - almost could not function at all. Now going to try in injectable form to see if that will not cause the side effects - hopeful."

   
2.0

Anonymous October 19, 2012

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"I am female, 41, have been taking methotrexate for 2 months now. I was crippled, my hands fingers wrists ankles balls of my feet knees shoulders arms even my jaw. I could barely walk I couldn't unscrew lids, peel potatoes, do everyday chores people take for granted. My rheumatoid factor was 1380. After 1 month no change hopefully my 2nd reading it will come down. Anyway after 1 month on the medication my joint pains has disappeared thanks to Methotrexate. I take 10mg once weekly with folic acid next day. Worked for me. YAY!"

   
10

Anonymous September 23, 2012

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"I have only been taking this medicine for a short while and the benefits are good so far. I am still able to keep working as a Paramedic which is physically demanding. Without my 20mg I slowly turn into a statue."

   
8.0

Uk lady (taken for 1 to 6 months) August 15, 2012

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"I have been taking the medication sine June 2011 I like it, but I'm always sick. It minimizes the pain and swelling, but it doesn't take it all away. I wake up every morning, and I can hardly move my ankles. I'm way to young to have to deal with this I'm only 22 years old. Some days I feel like I'm suffering, and if I'm sick I can't even walk."

   
8.0

Anonymous March 1, 2012

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"Started taking methotrexate 24th November 4 x 2.5mg weekly. Didn't feel to bad until Sat 3rd December and felt really ill. I had the flu jab as well hopefully things will improve but I was in bed from Saturday until today and I have a taste of metal in my mouth, I can't eat and haven't enjoyed a cup of tea. I also take the folic acid. I have lost 4lb in weight since Saturday."

Anonymous December 6, 2011

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"I have been taking this medicine since June and recently increased my dose. This medication has not worked for me at all. I continue to have pain and swelling in my wrist and fingers. The only thing that works for me is prednisone."

   
3.0

Anonymous November 15, 2011

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"I'm 30 years old and have been on 20mg of methotrexate for 2 years now. While I have experienced some side effects (mainly abdominal pain) I would not and will not stop taking it. So far for me the benefits have far outweighed any costs of being on methotrexate. The disease activity has dropped and I have far less swelling in my wrists, fingers and shoulders and have been able to get back into bowling leagues which I love."

   
9.0

Anonymous October 13, 2011

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"I have taken this medicine for over 10 years, so far it has helped stop the disease. "

   
9.0

Anonymous June 24, 2011

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