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User Reviews for Methotrexate

Also known as: Folex PFS, Methotrexate LPF Sodium, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Methotrexate.

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10
   
26%(12)
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22%(10)
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22%(10)
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9%(4)
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7%(3)
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Methotrexate Rating Summary

7.9/10 Average Rating

47 Ratings with 42 User Reviews

What next?Compare all 331 medications used in the treatment of Rheumatoid Arthritis.

Reviews for Methotrexate to treat Rheumatoid Arthritis

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"Following treatment for acute auto-immune disease of the brain I suddenly developed RA symptoms in my hands and feet - dropping things all day, severe overnight swelling and pain. Two previous medications prescribed by my rheumatologist were ineffective. Tried Methotrexate (8 x 2.5mg once/week folic acid) two days ago and 50% of swelling and 90% of the pain are gone; can make a more-or-less painless fist with both hands, easy to type first thing in the morning (woo hoo) and happy to be alive."

   
9.0

Mister Moo (taken for less than 1 month) January 28, 2016

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"I have had rheumatoid arthritis 15 years severe & aggressive. Finding a good rheumatologist has been impossible. I take Humira, methotrexate, folic acid. Taking the prescribed dose of methotrexate10 mg once a week. I am so lethargic, still stiff hands, feet joints as well as pain. It is better than no medication because that pain is fire, this has dulled the fire. Had one surgery shoulder.. My hair has been rapidly falling out again, I can't eat normally. After reading this blog I realize I may do better with either injections or stopping completely. Planquenil, sulfa-salazine were of no benefit. Allergci to biologics. Had to find one that has been a game changer."

   
5.0

Sparks203 January 23, 2016

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"I was put on methotrexate about 5 months ago after a nasty flare up back in the spring. I have had arthritis in my left knee since the age of 2 but found the arthritis went into remission all through my teens and has kind of been in and out of remission throughout my 20's. Steroid injections always worked well but this time around, it did nothing. The R/A has now spread to shoulders and wrists as well so I was put on methatrexate 20mg once a week along with hydroxychloriquine. I have found that it has only been the last couple of weeks that I am starting to feel some benefit from the meds, the knee pain is much better although my wrists are still very painful especially at night! My consultant assures me the meds will work. Fingers crossed"

   
7.0

Emma jd January 18, 2016

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"Methotrexate has been a miracle for me. For the past 3 years experiencing extreme tiredness, no energy to do anything, thankful to get through a day's work. Tried every combination of vitamins the world has ever made without any results. Then over last one year severe inflammation of hands, could barely make a fist, difficulty using hands. Under rheumatologist advice used 2 other medications till placed on methotrexate with a dose of 5 pills per week. Have been on this dose past 8 months with great results. Have been walking, biking around from 2 to 4 miles frequently, mowing grass, doing property maintenance 6 to 8 hrs per day and still having energy to continue working on other things! Crossing fingers, THANKS METHOTREXATE!"

   
10

jFr123 December 22, 2015

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"I am 23 years old, I was diagnosed with RA at age 21. My pain, swelling & fatigue was so severe, I could barely walk and had to be in a wheelchair during my hospital stay. My Rheum. started me on MTX immediately along with prednisone. At one point I was also taking Enbrel (biologic), but the auto injections were so painful, it outweighed the benefit of the drug and I stopped taking it. I am now only taking prednisone during flare ups and take 25 mgs of MTX every week. The RA already makes me so tired, the added side effects of MTX are next to unbearable. The day after I take the drug, I am so fatigued, I can barely pick my head up. The nausea and vomitting is awful. It is: Would you rather not be able to walk? Or walk and be sick?"

   
5.0

Kari Zari (taken for 2 to 5 years) November 29, 2015

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"When I was first diagnosed my hands hurt so badly I wondered how I could convince my doctor to amputate them and give me prosthetics. Methotrexate was among the first things tried to get my RA under control. After steroids, a variety of IV therapies, and anti-inflammatories Methotrexate has been my mainstay and keeps my RA under control as well as the biologics. I take it orally with no side effects. Yeah for Methotrexate in my life."

   
9.0

211106 September 17, 2015

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"Methotrexate has helped with the pain, but no one told me that it could affect my blood glucose and pressure. I worked for 3 years to control my diabetes with diet and had just completely normalized my glucose levels. Methotrexate ruined that with the first dose. So should a person take it and add additional BP meds and have to go on diabetes meds?"

   
5.0

Devora2 September 16, 2015

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"I took Methotrexate for 17 years. Started with tablets but progressed to injections for less chance of side effects (and cheaper!). Always felt tired and nauseous for a day after, which got worse and lasted longer over the years, so that instead of just folic acid, my rheum had me take leucovorin the day after (a stronger folic acid). But 6 months ago I developed fatigue, malaise and chronic low grade fever despite normal blood tests; my rheum said he had seen that before in other patients taking Methotrexate and considered it a toxic reaction! There is no literature on this reaction, but I got better once I stopped, so just be aware."

   
5.0

CCEA August 13, 2015

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"When all other meds/combo of meds failed my rheumy put me on mtx (8 tabs@ 2.5 mg. once a week). I still take 4 mg prednisone twice a day, 400 mg of plaquenil at night, and folic acid every morning. It's been a long road and a lot of ups and downs but I have seen the most progress since mtx was added to my combo of meds. I still have some pain but the stiffness (which used to last most of the day) and the swelling has improved. I am always nauseous and feel lethargic the first 24 - 48 hours after the mtx dose but 1-2 days of that is better than the alternative. I've always been extremely active so it has been rough struggling to do simple things."

   
10

Annie M (taken for 1 to 6 months) July 31, 2015

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"I got my RA seven years ago and have eaten Mtx since then. For me it has worked great. I had no weird side effects either. I ate 8 tablets a week for seven years, but now I'm down to 6 tablets .... it works great too. I am Swedish, and our Mtx looks a bit different."

   
10

MisoPretty July 19, 2015

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"I was diagnosed at 10mths old after a knee biopsy. I have been taking methotrexate on & off since I was 16 years old & I am now 41 years old. This medication has greatly reduce the activity of the disease & has increased the quality of my life greatly. I have just changed from methotrexate oral tablets to methotrexate injections. The tablets were making me feel nauseous so my specialist decided to put me on injections to bypass my stomach. The injections are easy to administer & relatively pain free. I am presently just trying to find the right dose for me due to suffering side effects. 15mg has caused me a severely sore lips & mouth, nausea, dizziness, lethargy & abdominal cramps. 12.5mg is the correct dose for me."

   
8.0

Sharrona July 19, 2015

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"Started mtx in early 2010, I was on it the better part of the last 5 years. I'm also on my fourth biologic. I take 2mg of folic acid daily. Last May I did a four day stretch in hospital because of bone marrow suppression. RBC, WBC, ANC, platelets and hemoglobin were very low. (ANC under 200). I was given leucorvorin rescue. This is a very rare side effect for low dose mtx. Although the drug only gave me a 10 to 20% improvement, the biologic gives me 60 to 90%. Now I'm about to start Arava, I wish I could retry the mtx at half dose as it doesn't cause much in the way of minor side effects. I often think of Huey Lewis and his song "I want a new drug"."

   
5.0

RheumTrucker (taken for 5 to 10 years) July 2, 2015

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"I have been on this medication for about 2 months now. I was taking prednisone before but that wouldn't help much. After the second week of taking methotrexate I can honestly say I am pain free. I can actually enjoy doing all the stuff I used to do before being diagnosed with RA. Before starting this medication I would experience horrible pain in my shoulders, hands, fingers, hips and ankles. I would have a rough time getting through the day. This medication works wonderfully."

   
10

Anonymous (taken for 1 to 6 months) June 5, 2015

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"I have been on Methotrexate 25mg for 6 weeks now, but 6 month for 20 mg and I have seen much improvement with my back pain. I do have severe rib and chest pain still, but the back pain is much better. I feel like a zombie though every day I can barely make it through the day. I am so upset about my hair. I have cut almost 6 inches off and still have dry damaged hair from the medicine. I loose handfuls of hair daily and the gi problems sometimes are pretty bad. So I don't know if the side effects out way the benefits. I wish I could have someone help Me fix these side effects and I would be ok. I think the fatigued is one of the worse though. :( ...."

   
7.0

Jenn Jenn June 2, 2015

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"I'm on my 3rd month and I do believe it's helping but the pain is still there. I have noticed as the dosage has increased it takes longer to bounce back and I'm unable to cut hair as that was my profession before diagnosis. I hope in time I will be able to get back to work but I am suffering several side effects. (hair falling out, unusually dry hair, quick to have to rest unlike before and several others) I was completely bed ridden before starting the medication so needless to say I don't want to try anything else because I am scared to take the chance that it won't work at all. I know I'm just beginning and hope in time the side effects will fade."

   
8.0

Jenni bug April 2, 2015

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"A couple of years ago my husband was at the point where he was limping severely, with swollen joints in his hands and feet. He was diagnosed with rheumatoid arthritis and began taking methotrexate at 20 mg once a week; he has since cut back to 17.5 mg. It has made a huge difference in his functioning, and he's pretty much back to normal. (Regular strength training at the YMCA has also helped a lot). He was also told to take folic acid once a day, which he does. The only negative is that his hair has thinned quite a bit, which is a common side effect. He is in his 70s."

   
10

AnonCat March 19, 2015

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"I have only been taking the Methotrexate since the end of September and I am on 25mg per week. I was also prescribed the Folic Acid but can't take that as it causes such an upset stomach that I stopped it all together. So far the only symptoms I have had were in the beginning and that was feeling nausea, and very tired the day after taking it. It has helped with the swelling and pain and I have no pain in my knees anymore and just a bit in the hands, wrists and my one foot."

   
8.0

Cocacolababy (taken for 1 to 6 months) November 22, 2014

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"Just taken my third dose of methotrexate this week (upped to 20mg after 2 weeks on 10mg)....take folic acid 5mg 3 x week. So far side effects have been manageable. Not sure if it's the medication or the steroid injections but I am starting to feel like my old self again. No swelling and little pain now so am now able to do the things I used to take for granted again. Feel hopeful about this medicine."

   
8.0

Dormouse (taken for less than 1 month) October 4, 2014

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"I have been taking methotrexate for two weeks now. Before taking this, I had pain in my hips, knees, ankle and could not walk on the heel of one of my feet. The pain was really bad. I am now walking on my foot again with little pain and do not feel so fatigued and tired, I do feel tired and a bit dizzy for a few days after the medication but not too bad. I am only taking 3 a week at moment, and about to take four, then five and six. Hopefully I wont have to many side affects."

   
7.0

maseymae (taken for less than 1 month) July 29, 2014

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"I have been on methotrexate for almost a year. I am up to 20 mg a week. I take folic acid and leucovorin calcium 12 hours after the methotrexate. I was taking Enbrel but now take Xeljanz. Before the biologics the methotrexate wasn't working very well. I take prednisone too. I am only 36 but at least I can function better than I did. I still flare about twice a month. I suffer side effects from methotrexate. My hair has severely thinned out and I get very tired after taking it. It looks like I'll be on it for a long time tho. Hopefully it gets better. I would really Like my hair to come back."

   
6.0

ACS3 July 5, 2014

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"I have been on methotrexate for two months now and have slowly increased my dose to 17.5mg/week. I started on a daily dose of folic acid but switched to a weekly dose of Leucovorin due to dizziness a couple of days after my Methotrexate dose. My pain and inflammation are gone and I feel so much better. I am once again able to do the things I love and have no side effects. I'm RF negative, but my rheumatologist chose to treat me quickly and aggressively based on symptoms and a high CCP. I'm thankful she did. I hope Methotrexate will be a long term solution to treat my rheumatoid arthritis."

   
10

Dpalmer63 (taken for 1 to 6 months) July 1, 2014

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"I've had rheumatoid arthritis (RA) for 35 years. I finally found a rheumatologist that was very good. I started on Plaquenil, which was great, but I developed an allergy to it. Switched to methotrexate oral, but had a hard time tolerating the nausea and diarrhea. Switched to injectable methotrexate, and had no nausea, limited diarrhea. It worked moderately well for the RA. Not completely pain free, but could do most things most days. I got cellulitis while on it, so had to go off for about 3 mos. When I went back to it, it didn't seem to work quite as well, and I realized I was experiencing more side effects than I was aware of the first time: thin skin, dermatitis, bruising, bleeding, hair falling out. New rheumatologist (my good one moved) decided to try Arava."

   
6.0

kpalchk (taken for 1 to 2 years) January 9, 2014

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"I have taken methotrexate for 17 years and am now on 20mg per week. I have also been on Rituximab infusions for the past 3 years and together the two medicines work very well. I am mostly pain free, except for mornings."

   
8.0

Nakuru5 July 1, 2013

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"After many years of joint pain, finally found a physician who looked at x-rays, labs, family history, my entire medical history and determined that I indeed had Rheumatiod Arthritis. I have noticed a significant change after being put on Methotrexate, Prednisone, Folic Acid, and Tramadol. However, now that winter is here, joints are worse and I am now on the highest dose of Methotrexate (20mg) a week but I'm able to get out and do more with less pain than before."

   
8.0

Big Momma 2012 (taken for 1 to 6 months) November 7, 2012

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Rheumatrex Dose Pack (methotrexate): "Took methotrexate for 6 months after diagnosis for Rheumatoid arthritis, seemed to work fairly well for the pain/stiffness, but I had terrible side effects including nausea, fatigue, mood swings - almost couldn't get to work, coming up stairs felt like my feet weighed 500 pounds each - almost could not function at all. Now going to try in injectable form to see if that will not cause the side effects - hopeful."

   
2.0

Anonymous October 19, 2012

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