User Reviews for Methotrexate

Also known as: Folex PFS, Methotrexate LPF Sodium, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Methotrexate.

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10
   
25%(7)
9
   
29%(8)
8
   
18%(5)
7
   
8%(2)
6
   
11%(3)
5
   
0%(0)
4
   
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3
   
8%(2)
2
   
4%(1)
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Methotrexate review summary

7.9/10 Average Rating

28 Ratings with 24 User Reviews

Compare all 344 medications used in the treatment of Rheumatoid Arthritis.

Reviews for Methotrexate to treat Rheumatoid Arthritis

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Review by maseymae (taken for less than 1 month):

User Rating:  
   
7.0

I have been taking methotrexate for two weeks now. Before taking this, I had pain in my hips, knees, ankle and could not walk on the heel of one of my feet. The pain was really bad. I am now walking on my foot again with little pain and do not feel so fatigued and tired, I do feel tired and a bit dizzy for a few days after the medication but not too bad. I am only taking 3 a week at moment, and about to take four, then five and six. Hopefully I wont have to many side affects.

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July 29, 2014 8:47 AM

Review by ACS3:

User Rating:  
   
6.0

I have been on methotrexate for almost a year. I am up to 20 mg a week. I take folic acid and leucovorin calcium 12 hours after the methotrexate. I was taking Enbrel but now take Xeljanz. Before the biologics the methotrexate wasn't working very well. I take prednisone too. I am only 36 but at least I can function better than I did. I still flare about twice a month. I suffer side effects from methotrexate. My hair has severely thinned out and I get very tired after taking it. It looks like I'll be on it for a long time tho. Hopefully it gets better. I would really Like my hair to come back.

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July 5, 2014 9:42 PM

Review by Dpalmer63 (taken for 1 to 6 months):

User Rating:  
   
10

I have been on methotrexate for two months now and have slowly increased my dose to 17.5mg/week. I started on a daily dose of folic acid but switched to a weekly dose of Leucovorin due to dizziness a couple of days after my Methotrexate dose. My pain and inflammation are gone and I feel so much better. I am once again able to do the things I love and have no side effects. I'm RF negative, but my rheumatologist chose to treat me quickly and aggressively based on symptoms and a high CCP. I'm thankful she did. I hope Methotrexate will be a long term solution to treat my rheumatoid arthritis.

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July 1, 2014 3:58 PM

Review by kpalchk (taken for 1 to 2 years):

User Rating:  
   
6.0

I've had rheumatoid arthritis (RA) for 35 years. I finally found a rheumatologist that was very good. I started on Plaquenil, which was great, but I developed an allergy to it. Switched to methotrexate oral, but had a hard time tolerating the nausea and diarrhea. Switched to injectable methotrexate, and had no nausea, limited diarrhea. It worked moderately well for the RA. Not completely pain free, but could do most things most days. I got cellulitis while on it, so had to go off for about 3 mos. When I went back to it, it didn't seem to work quite as well, and I realized I was experiencing more side effects than I was aware of the first time: thin skin, dermatitis, bruising, bleeding, hair falling out. New rheumatologist (my good one moved) decided to try Arava.

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January 9, 2014 9:12 PM

Review by Nakuru5:

User Rating:  
   
8.0

I have taken methotrexate for 17 years and am now on 20mg per week. I have also been on Rituximab infusions for the past 3 years and together the two medicines work very well. I am mostly pain free, except for mornings.

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July 1, 2013 4:36 PM

Review by Big Momma 2012 (taken for 1 to 6 months):

User Rating:  
   
8.0

After many years of joint pain, finally found a physician who looked at x-rays, labs, family history, my entire medical history and determined that I indeed had Rheumatiod Arthritis. I have noticed a significant change after being put on Methotrexate, Prednisone, Folic Acid, and Tramadol. However, now that winter is here, joints are worse and I am now on the highest dose of Methotrexate (20mg) a week but I'm able to get out and do more with less pain than before.

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November 7, 2012 3:21 PM

Review by Anonymous:

User Rating:  
   
2.0

Rheumatrex Dose Pack (methotrexate): Took methotrexate for 6 months after diagnosis for Rheumatoid arthritis, seemed to work fairly well for the pain/stiffness, but I had terrible side effects including nausea, fatigue, mood swings - almost couldn't get to work, coming up stairs felt like my feet weighed 500 pounds each - almost could not function at all. Now going to try in injectable form to see if that will not cause the side effects - hopeful.

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October 19, 2012 1:50 PM

Review by Anonymous:

User Rating:  
   
10

I am female, 41, have been taking methotrexate for 2 months now. I was crippled, my hands fingers wrists ankles balls of my feet knees shoulders arms even my jaw. I could barely walk I couldn't unscrew lids, peel potatoes, do everyday chores people take for granted. My rheumatoid factor was 1380. After 1 month no change hopefully my 2nd reading it will come down. Anyway after 1 month on the medication my joint pains has disappeared thanks to Methotrexate. I take 10mg once weekly with folic acid next day. Worked for me. YAY!

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September 23, 2012 12:06 PM

Review by Uk lady (taken for 1 to 6 months):

User Rating:  
   
8.0

I have only been taking this medicine for a short while and the benefits are good so far. I am still able to keep working as a Paramedic which is physically demanding. Without my 20mg I slowly turn into a statue.

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August 15, 2012 7:43 PM

Review by Anonymous:

User Rating:  
   
8.0

I have been taking the medication sine June 2011 I like it, but I'm always sick. It minimizes the pain and swelling, but it doesn't take it all away. I wake up every morning, and I can hardly move my ankles. I'm way to young to have to deal with this I'm only 22 years old. Some days I feel like I'm suffering, and if I'm sick I can't even walk.

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March 1, 2012 8:01 PM

Review by Anonymous:

Started taking methotrexate 24th November 4 x 2.5mg weekly. Didn't feel to bad until Sat 3rd December and felt really ill. I had the flu jab as well hopefully things will improve but I was in bed from Saturday until today and I have a taste of metal in my mouth, I can't eat and haven't enjoyed a cup of tea. I also take the folic acid. I have lost 4lb in weight since Saturday.

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December 6, 2011 6:00 PM

Review by Anonymous:

User Rating:  
   
3.0

I have been taking this medicine since June and recently increased my dose. This medication has not worked for me at all. I continue to have pain and swelling in my wrist and fingers. The only thing that works for me is prednisone.

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November 15, 2011 11:10 PM

Review by Anonymous:

User Rating:  
   
9.0

I'm 30 years old and have been on 20mg of methotrexate for 2 years now. While I have experienced some side effects (mainly abdominal pain) I would not and will not stop taking it. So far for me the benefits have far outweighed any costs of being on methotrexate. The disease activity has dropped and I have far less swelling in my wrists, fingers and shoulders and have been able to get back into bowling leagues which I love.

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October 13, 2011 10:25 AM

Review by Anonymous:

User Rating:  
   
9.0

I have taken this medicine for over 10 years, so far it has helped stop the disease.

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June 24, 2011 12:28 PM

Review by Anonymous:

Taking 12.5mg/week along with Prilosec due to stomach ulcers from too many NSAIDS. Works well on the rheumatoid arthritis symptoms. Have been bumping the dose up from 7.5 mg/week and have now run into low platelet count 85 when it should run between 150 and 400. I'm backing off of the methotrexate to see if I get a recovery of my platelet levels. Did a two month stint without methotrexate and was in massive pain (all the Vicodin in the world could not touch it). It works but hopefully I'll be able to get by on the lower dose and get a comeback in platelet levels.

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March 23, 2011 3:21 PM

Review by peter webb:

User Rating:  
   
10

This medicine is wonderful. Without it I could not move my fingers and wrists and my knees and ankles. I feel normal and people cannot believe that I have RA. The only down side is my skin on my arms is thinned and very easy to bruise and bleed and marks but as this is a small price to pay for a normal lifestyle and to be able to work.

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January 12, 2011 2:16 AM

Review by DHollenbach:

User Rating:  
   
10

I take 20mg methotrexate each week and it is so wonderful to feel 'normal' again. I have no side effects with it and all my pain is gone. Love it!

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January 8, 2011 3:05 PM

Review by Anonymous:

User Rating:  
   
7.0

It definitely helps with the pain and mobility part of rheumatoid arthritis, but I am nauseous usually 2 or three days after I do the shot. I'm also tired a lot and feel weak after I take my weekly shot. Sometimes I don't take it consistently because I don't feel like being sick that week. I do enjoy it when my fingers actually bend though.

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June 19, 2010 1:32 PM

Review by sweeneyjack:

User Rating:  
   
10

I am 39 years old and take 22.5 mg per week and would be lost without it. It does make rheumatoid arthritis more livable.

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September 11, 2009 4:37 PM

Review by Tennessee Ireland:

User Rating:  
   
9.0

After almost 3 years of usage, and refining the dosage, I feel better at 65 years old than I did at 50.

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June 18, 2009 2:31 PM

Review by Bunionette:

User Rating:  
   
9.0

I have been taking methotrexate for about 2 years for moderate rheumatoid arthritis (22.5mg weekly) and it does control inflammation. I recently stopped taking it for 3 months because I really don't like taking drugs and symptoms returned (inflammation in ankles, hip pain, stiffness) so I started taking it again and have no pain so obviously it was working.

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May 25, 2009 12:38 PM

Review by Anonymous:

User Rating:  
   
9.0

At first I was really apprehensive about taking Methotrexate (7.5mg a week), but it seems to be working well. I've been taking it since November 2008. My side effects are minimal. Once a week I get nausea, which usually occurs the day after I take my weekly dose. My tests results have come back normal too. I 'm not a medicine taker and the idea of taking such a strong medication still scares me, but I will continue with my weekly dosage because it helps with my rheumatoid arthritis a lot. One thing I'm consistent with is taking my Folic Acid since it helps prevent my side effects. I don't even get the very common mouth sores.

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March 29, 2009 6:52 PM

Review by Anonymous:

User Rating:  
   
9.0

This medication has made my life so much more bearable. It is not a miracle drug. I still have pain, but now I can get around and do things for myself.

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September 26, 2008 12:29 AM

Review by Anonymous:

User Rating:  
   
10

Without this drug I would be disabled.

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August 10, 2008 4:10 PM

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