Generic Name: methotrexate (oral) (meth oh TREX ate)
Brand Name: Rheumatrex Dose Pack, Trexall
What is methotrexate?
Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.
Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.
Methotrexate may also be used for purposes not listed in this medication guide.
What is the most important information I should know about methotrexate?
Methotrexate is usually taken once or twice per week and not every day. You must use the correct dose of methotrexate for your condition. Some people have died after taking methotrexate every day by accident.
Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have liver disease (especially if caused by alcoholism), or a blood cell or bone marrow disorder.
Do not use methotrexate if you are pregnant or breast-feeding a baby.
Methotrexate can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
Methotrexate can cause serious or life-threatening side effects on your liver, lungs, or kidneys. Tell your doctor if you have upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), dry cough, shortness of breath, blood in your urine, or little or no urinating.
What should I discuss with my healthcare provider before taking methotrexate?
You should not use this medicine if you are allergic to methotrexate. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have:
alcoholism, cirrhosis, or other liver disease;
a blood cell disorder such as anemia (lack of red blood cells) or leukopenia (lack of white blood cells);
a bone marrow disorder; or
if you are breast-feeding a baby.
Methotrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you.
To make sure methotrexate is safe for you, tell your doctor if you have:
a folate deficiency;
pneumonia or lung disease;
any type of infection; or
if you are receiving radiation treatments.
FDA pregnancy category X. Methotrexate can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
You may need to have a negative pregnancy test before starting this treatment.
Use birth control to prevent pregnancy while you are using methotrexate, whether you are a man or a woman. Methotrexate use by either parent may cause birth defects.
If you are a man, use a condom to keep from causing a pregnancy while you are using methotrexate. Continue using condoms for at least 90 days after your treatment ends.
If you are a woman, use an effective form of birth control while you are taking methotrexate, and for at least one cycle of ovulation after your treatment ends.
Do not give this medicine to a child without the advice of a doctor.
Older adults may be more likely to have side effects from this medication.
How should I take methotrexate?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You must use the correct dose of methotrexate for your condition. Methotrexate is sometimes taken once or twice per week and not every day. Follow the directions on your prescription label. Some people have died after taking methotrexate every day by accident. Ask your doctor or pharmacist if you have questions about your dose of methotrexate or how often to take it.
Use methotrexate regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Methotrexate can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often, and you may need an occasional liver biopsy. Your cancer treatments may be delayed based on the results of these tests.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of methotrexate.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of methotrexate can be fatal.
What should I avoid while taking methotrexate?
This medicine can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds), especially if you are being treated for psoriasis. Methotrexate can make your skin more sensitive to sunlight and your psoriasis may worsen.
Avoid drinking alcohol while taking methotrexate.
Methotrexate side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using methotrexate and call your doctor at once if you have:
dry cough, shortness of breath;
diarrhea, vomiting, white patches or sores inside your mouth or on your lips;
blood in your urine or stools;
swelling, rapid weight gain, little or no urinating;
fever, chills, body aches, flu symptoms;
pale skin, easy bruising, unusual bleeding, weakness, feeling light-headed or short of breath;
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
vomiting, upset stomach;
headache, dizziness, tired feeling; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect methotrexate?
Many drugs can interact with methotrexate. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with methotrexate, especially:
an antibiotic or sulfa drugs;
isotretinoin, retinol, tretinoin;
NSAIDs (non-steroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or
salicylates such as aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others.
This list is not complete and many other drugs can interact with methotrexate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
More about Trexall (methotrexate)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about methotrexate.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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