Nimbex

Generic Name: cisatracurium (sis-AT-ra-KURE-ee-um)
Brand Name: Nimbex

Nimbex is used for:

Providing muscle relaxation during surgery, medically assisted breathing, or insertion of a breathing tube.

Nimbex is a nondepolarizing skeletal muscle relaxant. It works by blocking the effects of acetylcholine, a chemical involved in muscle contraction. This relaxes muscles in the body before surgery or insertion of a breathing tube.

Do NOT use Nimbex if:

  • you are allergic to any ingredient in Nimbex

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Nimbex:

Some medical conditions may interact with Nimbex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to other neuromuscular blocking agents (eg, succinylcholine)
  • if you have muscle weakness or partial paralysis on one side of the body, partial paralysis affecting the lower limbs, a neuromuscular problem (eg, Lambert-Eaton myasthenic syndrome, myasthenia gravis), a blood electrolyte problem, an acid-base problem, tissue wasting, or burns
  • if you are debilitated

Some MEDICINES MAY INTERACT with Nimbex. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aminoglycoside (eg, gentamicin), bacitracin, clindamycin/lincomycin, colistin, cyclosporine, ketamine, lithium, local anesthetics (eg, lidocaine), magnesium salts (eg, magnesium sulfate), polymyxins, polypeptide antibiotics (eg, actinomycin), procainamide, quinidine, quinine, sodium colistimethate, tetracyclines (eg, doxycycline), trimethaphan, or verapamil because they may increase the actions and risk of Nimbex's side effects
  • Carbamazepine, inhaled general anesthetics (eg, halothane), phenytoin, or theophyllines (eg, aminophylline) because they may decrease Nimbex's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nimbex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nimbex:

Use Nimbex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Nimbex is usually given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • Do not use Nimbex if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Nimbex, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Nimbex.

Important safety information:

  • Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Nimbex or other medicines you were given during surgery. Using Nimbex alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Tell your doctor or dentist that you take Nimbex before you receive any medical or dental care, emergency care, or surgery.
  • Some of these products may contain benzyl alcohol. If you have ever had an allergic reaction to benzyl alcohol, ask your doctor or pharmacist if your medicine has benzyl alcohol in it.
  • Some forms of Nimbex contain benzyl alcohol. Do not use medicine with benzyl alcohol in NEWBORNS or INFANTS. It may cause serious and sometimes fatal side effects. If you have questions, check with your doctor or pharmacist.
  • Nimbex should be used with extreme caution in CHILDREN younger than 1 month old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using Nimbex during pregnancy. It is not known if Nimbex is found in breast milk. If you are or will be breast-feeding while you are using Nimbex, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Nimbex:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with the use of Nimbex. If you notice any unusual effects, contact your doctor or pharmacist. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); fainting; flushing; itching; muscle weakness; rash; slow or irregular heartbeat; severe or persistent dizziness; trouble speaking or breathing; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include prolonged muscle paralysis.

Proper storage of Nimbex:

Nimbex is usually handled and stored by a health care provider. If you are using Nimbex at home, store Nimbex as directed by your pharmacist or health care provider. Keep Nimbex, as well as needles and syringes, out of the reach of children and away from pets.

General information:

  • If you have any questions about Nimbex, please talk with your doctor, pharmacist, or other health care provider.
  • Nimbex is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Nimbex or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Nimbex. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Nimbex. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Nimbex.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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