Vizz Eye Drops
Generic name: aceclidine
Dosage form: eye drop (ophthalmic solution)
What are Vizz eye drops?
Vizz (aceclidine) is a once-daily eye drop used to improve blurry near vision associated with aging (presbyopia). Vizz eye drops work by contracting the iris muscle, which makes the pupil smaller and increases the depth of focus.
Vizz's mechanism of action is as a cholinergic muscarinic receptor agonist that stimulates the muscarinic receptors on the iris muscle, which causes the pupil to constrict.
Vizz eye drops are applied once a day, with results expected within 30 minutes and may last up to 10 hours. It will be available in single-use vials.
Vizz FDA approval was granted on July 31, 2025, after positive results from the clinical trials CLARITY 1 (NCT05656027), CLARITY 2 (NCT05728944), and CLARITY 3 (NCT05753189).
Vizz eye drops side effects
The most common Vizz eye drop side effects are eye irritation (20%), dim vision (16%), and headache (13%). These side effects are usually mild, short-term, and resolve on their own.
This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Related/similar drugs
What to avoid
Do not drive or operate machinery if vision is not clear (e.g., blurred vision). Patients may experience temporary dim or dark vision. Exercise caution in night driving and other hazardous activities in poor light.
Warnings
Blurred Vision: You may experience temporary dim or dark vision after using Vizz eye drops. Do not drive or operate machinery if you do not have clear vision (e.g., blurred vision). Exercise caution in night driving and other hazardous activities in poor light.
Risk of Retinal Tear/Detachment: Rare cases of retinal tears and detachments have been reported with medications that cause the pupils to constrict or become smaller. Examination of the retina is advised in all patients before using these eye drops. Patients should be advised to seek immediate medical care with the sudden onset of vision loss, flashing lights, or floaters.
Iritis: Vizz eye drops should be used with caution in patients with a history of iritis, which is inflammation of the iris, the colored circle of the eye.
Before using this medicine
Tell your healthcare provider if you:
- have a known hypersensitivity to aceclidine or any other ingredient in these eyedrops
- are pregnant or planning a pregnancy, as there have been no adequate and well-controlled studies of Vizz eye drops administration in pregnant women to inform a drug-associated risk.
- are breastfeeding or planning to breastfeed, as there is no information regarding the presence of this medicine or its metabolite in human or animal milk, the effects on the breastfed infant, or the effects on milk production. Therefore, the risk of Vizz eye drops to an infant during lactation is unknown.
How should I use Vizz eye drops?
Vizz eye drops are used once a day.
Instill one drop in each eye, wait 2 minutes, then instill a second drop in each eye using the same single-dose vial.
Contact lenses should be removed before instilling Vizz eye drops, and contact lenses may be reinserted 10 minutes afterwards.
If you use other eye drop products, then the eye drops should be administered at least 5 minutes apart.
What other drugs will affect this medicine?
Tell your healthcare providers about all medicines that you take or use, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Storage
Store Vizz eye drops refrigerated at 36°F to 46°F (2°C to 8°C). Do not freeze. When stored in refrigerated conditions, Vizz eye drops can be used until the expiration date.
Once pouch or vial(s) are removed from refrigeration, eye drops may be stored at room temperature [up to 77°F (25°C)] but must be used within 30 days. Discard the opened single-dose vial after use.
Ingredients
Active ingredient: aceclidine hydrochloride 1.75% (17.82 mg)
Inactive ingredients: polysorbate 80, mannitol, hypromellose, edetate disodium dihydrate, sodium citrate dihydrate, water for injection, and may also include hydrochloric acid and/or sodium hydroxide for pH adjustment to between 4.5 and 5.5, if necessary.
Vizz eye drops do not contain antimicrobial preservatives.
Company
Vizz by LENZ Therapeutics, Inc., 201 Lomas Santa Fe Drive, Suite 300, Solana Beach, CA 92075, USA
References
More about Vizz (aceclidine ophthalmic)
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.