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Active substance(s): COLESTYRAMINE

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Package leaflet: Information for the patient
Questran™ 4g/sachet Powder for Oral Suspension,
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
- If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.
What is in this leaflet
1. What QUESTRAN is and what it is used for
2. What you need to know before you take QUESTRAN
3. How to take QUESTRAN
4. Possible side effects
5. How to store QUESTRAN
6. Contents of the pack and other information
1. What QUESTRAN is and what it is used for
Questran is supplied as sachets. Each sachet contains 4g of the active substance colestyramine.
Colestyramine belongs to a group of medicines called bile acid binding resins.
Questran is used to lower your body’s level of cholesterol (a type of fat) which can cause heart disease.
This medicine works in the digestive system and absorbs the cholesterol-containing bile acids, which then pass out through the body in the faeces.
Questran may also be used to help stop some types of diarrhoea or itching.
2. What you need to know before you take QUESTRAN
Do not take QUESTRAN:
- if you are allergic to colestyramine or any of the other ingredients of this medicine (listed in section 6), or a similar medicine.
- if you have an illness which results in your bile duct being completely blocked (e.g. gall stones). Check with your doctor if you are unsure.
Warnings and precautions
Talk to your doctor or pharmacist before taking Questran if:
- you are diabetic as Questran contains sucrose.
- you are in a long-term treatment with high doses of Questran as it may reduce the body’s ability to absorb fat-soluble vitamins from the diet.
These include vitamins A, D and K. Therefore your doctor may suggest you take a vitamin supplement.
- this medicine is being given to a child where there is a family history of high blood cholesterol levels. An additional supplement of folic acid may
be advised.
This medicine is not suitable for children under 6 years of age.
Other medicines and QUESTRAN
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
If you are taking any other medicines it is important that they are taken at a different time to your dose of Questran.
Any other medicines should be taken at least 1 hour before you take your dose of Questran or 4 – 6 hours after you have taken your dose of
This is because Questran may change the effects of other medicines by stopping them from working so well and Questran preparations can stay
in the digestive system and can stop other medicines from being absorbed by the body.
QUESTRAN with food, drink and alcohol
It is recommended that your alcohol intake is kept within the recommended guidelines as advised by your doctor, as alcohol can increase your
cholesterol level.
If you have been prescribed this medicine to reduce your cholesterol levels, it is recommended that you follow a low fat diet as advised by your
Pregnancy and breast-feeding
You should not take this medicine if you are pregnant, planning to become pregnant or are breast-feeding, unless your doctor recommends it.
Driving and using machines
Questran have not been shown to impair your ability to drive or use machines.
QUESTRAN contains sucrose
Questran contains 3.79g sucrose per sachet. This should be taken into account in patients with diabetes mellitus. If you have been told by your
doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
3. How to take QUESTRAN
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
To lower cholesterol levels
The recommended dose is 3 – 6 sachets a day. This can be taken as a single dose or divided doses up to 4 times a day.
To relieve itching
The recommended dose is one or two sachets each day.
To manage diarrhoea
The recommended dose is 3-6 sachets a day. This can be taken as a single dose or divided doses up to 4 times a day.
Children (6 - 12 years)
The dose to be given to children will depend on the child’s weight, which the doctor will work out for you.
Children under 6 years
This medicine is not recommended for children under the age of 6.

How to make up the sachets
1. The contents of one sachet should be sprinkled evenly on to 150ml (4-6 fluid oz) of water or fruit juice.
2. Allow to stand for 1 or 2 minutes.
3. Once the powder has soaked into the liquid, stir or shake it to mix in thoroughly.
Do not take this medicine in its dry form as it may cause you to choke.
Questran can be mixed with water, fruit juice, skimmed milk, thin soups or fruit smoothies or sauces (e.g. apple sauce).
Keep taking your medicine until your doctor tells you to stop. Your doctor will want you to have regular check-ups whilst you are taking this
If you take more QUESTRAN than you should
Go to your nearest hospital Casualty Department or tell your doctor immediately. Take the empty container and any remaining sachets with you.
If you forget to take QUESTRAN
If you miss a dose do not worry. Take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue
as before.
Do not take a double dose to make up for the forgotten dose.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
The most frequent side effect seen is constipation. To minimise this effect you will usually start with a low dose and increase it slowly until you are
taking the full number of sachets as prescribed by your doctor. This side effect usually reduces over time.
Other side effects, less common, include:
- bloatedness,
- wind (flatulence),
- feeling sick (nausea) or vomiting,
- diarrhoea,
- heartburn,
- anorexia, weight loss or gain,
- indigestion (dyspepsia),
- problems with your body’s ability to absorb food correctly leading to grey, bulky or smelly stools (steatorrhea),
- increased tendency to bleed, which may also be seen with vitamin D, vitamin K or vitamin A deficiency (which may rarely result in night blindness),
- increased level of chloride in the blood (hyperchloremic acidosis) especially in children,
- thin or brittle bones (osteoporosis),
- rash, itching, irritation of skin, tongue or around the anus,
Rare reports of obstruction of the intestine have been seen.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card Scheme at:
By reporting side effects you can help provide more information on the safety of this medicine.
5. How to store QUESTRAN
Keep this medicine out of the sight and reach of children.
Do not store above 30ºC.
Do not use this medicine after the expiry date which is stated on the carton and sachet. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use.
These measures will help protect the environment.
6. Contents of the pack and other information
What QUESTRAN contains
- The active substance is colestyramine. Questran sachets each contain 4 grams colestyramine.
- The other ingredients are: acacia, citric acid anhydrous, orange juice flavour, polysorbate 80, propylene glycol alginate, sucrose.
What QUESTRAN looks like and contents of the pack
Questran come in the form of a powder and are supplied in packs of 50 sachets.
This medicine is orange-flavoured.
Marketing Authorisation Holder and Manufacturer
Marketing Authorisation Holder
Bristol-Myers Pharmaceuticals
Uxbridge Business Park
Sanderson Road
Uxbridge, UB8 1DH, England
Tel: 0800 7311736
10 rue Bouche Thomas
ZAC d’Orgemont
49000 Angers
This leaflet was last revised in March 2015.


ACH 21510 - A
Article 61(3)

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