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Zemplar Side Effects

Generic name: paricalcitol

Medically reviewed by Drugs.com. Last updated on Oct 22, 2023.

Note: This document contains side effect information about paricalcitol. Some dosage forms listed on this page may not apply to the brand name Zemplar.

Applies to paricalcitol: oral capsule liquid filled. Other dosage forms:

Serious side effects of Zemplar

Along with its needed effects, paricalcitol (the active ingredient contained in Zemplar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking paricalcitol:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking paricalcitol:

Symptoms of overdose

Other side effects of Zemplar

Some side effects of paricalcitol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to paricalcitol: intravenous solution, oral capsule.

General

The most common adverse events were nausea, diarrhea, and elevated calcium phosphate product.[Ref]

Gastrointestinal

Very common (10% or more): Nausea (12.9%), diarrhea (11.5%)

Common (1% to 10%): Vomiting, constipation, gastrointestinal hemorrhage, abdominal discomfort, dry mouth, gastroenteritis, stomach discomfort, gastroesophageal reflux disease

Uncommon (0.1% to 1%): Rectal hemorrhage, colitis, gastritis, dyspepsia, dysphagia, abdominal pain, gastrointestinal disorder

Frequency not reported: Intestinal ischemia, gastrointestinal hemorrhage[Ref]

Metabolic

Very common (10% or more): Elevated calcium phosphate product (12%)

Common (1% to 10%): Fluid overload, hypoglycemia, dehydration, hypercalcemia, hypocalcemia, decreased appetite, hyperphosphatemia

Uncommon (0.1% to 1%): Hyperkalemia, anorexia, thirst[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, hypotension, palpitations

Uncommon (0.1% to 1%): Cardiac arrest, arrhythmia, atrial flutter

Frequency not reported: Irregular heart rate[Ref]

Nervous system

Common (1% to 10%): Vertigo, dizziness, headache, syncope, dysgeusia

Uncommon (0.1% to 1%): Coma, cerebrovascular accident, transient ischemic attack, myoclonus, hypoesthesia, paresthesia, gait disturbance

Frequency not reported: Unresponsive to stimuli[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, pneumonia, influenza, oropharyngeal pain, sinusitis, cough

Uncommon (0.1% to 1%): Pulmonary edema, asthma, dyspnea, epistaxis, pharyngitis

Frequency not reported: Upper respiratory tract infection, orthopnea, wheezing[Ref]

Other

Common (1% to 10%): Viral infection, edema, peritonitis, chills, pyrexia, pain, fatigue, peripheral edema, malaise, chest pain, fungal infection, infection

Uncommon (0.1% to 1%): Laboratory test abnormal, decreased weight, ear disorder, condition aggravated, asthenia

Frequency not reported: Phosphorous increased, ear discomfort, chest discomfort, feeling abnormal, swelling[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity

Postmarketing reports: Allergic reactions including rash, urticaria, and angioedema (including laryngeal edema)[Ref]

Dermatologic

Common (1% to 10%): Rash, pruritus, skin ulcer, acne

Uncommon (0.1% to 1%): Urticaria, bullous dermatitis, alopecia, hirsutism, hyperhidrosis

Frequency not reported: Blister, night sweats, rash pruritic, skin burning sensation[Ref]

Endocrine

Common (1% to 10%): Hypoparathyroidism

Uncommon (0.1% to 1%): Hyperparathyroidism[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, breast tenderness

Uncommon (0.1% to 1%): Vaginal infection, breast pain, erectile dysfunction[Ref]

Musculoskeletal

Common (1% to 10%): Chills, arthralgia, arthritis, back pain, muscle spasms

Uncommon (0.1% to 1%): Joint stiffness, muscle twitching, myalgia[Ref]

Renal

Common (1% to 10%): Renal failure chronic

Uncommon (0.1% to 1%): Blood creatinine increased[Ref]

Immunologic

Common (1% to 10%): Sepsis[Ref]

Psychiatric

Common (1% to 10%): Insomnia, anxiety, depression

Uncommon (0.1% to 1%): Confusional state, delirium, depersonalization, agitation, nervousness

Frequency not reported: Restlessness[Ref]

Hematologic

Uncommon (0.1% to 1%): Bleeding time prolonged, anemia, leukopenia, lymphadenopathy[Ref]

Hepatic

Uncommon (0.1% to 1%): Hepatic enzyme abnormal, increased aspartate aminotransferase

Frequency not reported: Alkaline phosphatase decreased[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis, glaucoma

Frequency not reported: Ocular hyperemia[Ref]

Oncologic

Uncommon (0.1% to 1%): Breast cancer[Ref]

Local

Uncommon (0.1% to 1%): Injection site pain

Frequency not reported: Injection site extravasation[Ref]

References

1. Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical. 2001.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.