Zefazone Side Effects
Generic name: cefmetazole
Note: This document contains side effect information about cefmetazole. Some dosage forms listed on this page may not apply to the brand name Zefazone.
Applies to cefmetazole: injectable powder for injection, intravenous solution.
Cefmetazole (the active ingredient contained in Zefazone) has been generally well tolerated. In large studies only 2% to 4% of patients reported side effects.[Ref]
Rare cases of cholestatic jaundice have been reported.
Hypersensitivity side effects have included rare reports of a rash (less than 1% of patients).[Ref]
A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.[Ref]
Although mild, insignificant hypoprothrombinemia has been reported. However, no clinically significant hemorrhage or increased bleeding times have been documented.[Ref]
Cardiovascular side effects have included informal reports of hypotension and shock, but the type of infection and clinical conditions of the patients made implication of cefmetazole (the active ingredient contained in Zefazone) difficult.[Ref]
Other side effects have included a possible overestimation of urine glucose by the copper reduction method of urine dipstick analysis (Clinitest).[Ref]
Renal side effects have included reports of new or worsened renal insufficiency. These were difficult to interpret due to underlying diseases and concomitant therapy.[Ref]
More about Zefazone (cefmetazole)
Related treatment guides
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2. Jones R "Cefmetazole (CS-1170), a "new" cephamycin with a decade of clinical experience." Diagn Microbiol Infect Dis 12 (1989): 367-79
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8. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 226
9. Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Sanchez F, Perez E, Venuti A, Blanca M "Immediate allergic reactions to cephalosporins: Cross-reactivity and selective responses." J Allerg Clin Immunol 106 (2000): 1177-83
10. Breen GA, Stpeter WL "Hypoprothrombinemia associated with cefmetazole." Ann Pharmacother 31 (1997): 180-4
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.