Vosoritide Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 27, 2024.

Applies to vosoritide: subcutaneous powder for solution.

Precautions

It is very important that your doctor check your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may increase risk of low blood pressure. Your doctor may ask you to let your child eat a meal and drink at least 240 to 300 mL of water within 1 hour before receiving this medicine to help reduce this risk. Check with your doctor right away if your child have blurred vision, confusion, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, sweating, or unusual tiredness or weakness.

Serious side effects of vosoritide

Along with its needed effects, vosoritide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vosoritide:

More common side effects

• blurred vision
• chills
• confusion
• cough
• diarrhea
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fever
• general feeling of discomfort or illness
• headache
• joint pain
• loss of appetite
• muscle aches and pains
• nausea
• runny nose
• shivering
• sore throat
• sweating
• trouble sleeping
• unusual tiredness or weakness
• vomiting

Other side effects of vosoritide

Some side effects of vosoritide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• difficulty in moving
• dry skin
• ear pain
• feeling of constant movement of self or surroundings
• hives, itching, rash, redness, swelling, or warmth at the injection site
• muscle pain or stiffness
• pain in the joints
• sensation of spinning
• stomach pain
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

For healthcare professionals

Applies to vosoritide: subcutaneous powder for injection.

General adverse events

The most common adverse effects were injection site reactions, vomiting, arthralgia, gastroenteritis and decreased blood pressure.^[Ref]

Cardiovascular

• Very common (10% or more): Decreased blood pressure (13%)^[Ref]

Dermatologic

• Common (1% to 10%): Dry skin^[Ref]

Gastrointestinal

• Very common (10% or more): Vomiting (27%), gastroenteritis (13%), diarrhea (10%)
• Common (1% to 10%): Nausea^[Ref]

Hypersensitivity

• Common (1% to 10%): Seasonal allergy^[Ref]

Immunologic

• Very common (10% or more): Anti-drug antibodies (35%)^[Ref]

Local

• Very common (10% or more): Injection site reactions (85%) including injection site erythema (75%), injection site swelling (62%), and injection site urticaria (25%)
• Frequency not reported: Injection site pain, injection site bruising, injection site pruritus, injection site hemorrhage, injection site discoloration, injection site induration^[Ref]

Metabolic

• Common (1% to 10%): Increased alkaline phosphatase^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (15%)^[Ref]

Nervous system

• Common (1% to 10%): Dizziness (included dizziness, syncope, presyncope, procedural dizziness, vertigo)^[Ref]

Other

• Common (1% to 10%): Ear pain, fatigue^[Ref]

Respiratory

• Very common (10% or more): Influenza (10%)^[Ref]

See also:

Further information

Vosoritide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer