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Visipaque Side Effects

Generic Name: iodixanol

Note: This document contains side effect information about iodixanol. Some of the dosage forms listed on this page may not apply to the brand name Visipaque.

For the Consumer

Applies to iodixanol: injection solution

Along with its needed effects, iodixanol (the active ingredient contained in Visipaque) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking iodixanol:

Less common
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • fainting
  • fast or irregular heartbeat
  • nausea
  • sweating
Rare
  • Agitation
  • blurred vision
  • coma
  • confusion
  • cough
  • decreased urine output
  • depression
  • difficulty breathing
  • dilated neck veins
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • feeling of warmth
  • headache
  • hostility
  • irregular breathing
  • irritability
  • lethargy
  • muscle twitching
  • noisy breathing
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • seizures
  • severe or sudden headache
  • stupor
  • sudden loss of coordination
  • sudden slurring of speech
  • swelling of the face, hands, fingers, lower legs, ankles, or feet
  • vomiting

Some side effects of iodixanol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Bad, unusual, or unpleasant (after) taste
  • burning, crawling, itching, numbness, prickling, "pins and needles", tingling feeling
  • change in taste
  • diarrhea
  • feeling of constant movement of self or surroundings
  • itching or skin rash
  • sensation of spinning
Rare
  • Acidic or sour stomach
  • anxiety
  • belching
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased awareness or responsiveness
  • dry mouth
  • general feeling of discomfort or illness
  • hearing loss
  • heartburn
  • hives or welts
  • hyperventilation
  • indigestion
  • restlessness
  • severe sleepiness
  • shaking
  • stomach discomfort, upset, or pain
  • transient, mild, pleasant aromatic odor

For Healthcare Professionals

Applies to iodixanol: injectable solution

General

Serious reactions as well as fatalities are only seen on very rare occasions. Serious adverse reactions may include acute/chronic renal failure, anaphylactic or anaphylactoid shock, hypersensitivity reaction followed by cardiac reactions (Kounis' syndrome), cardiac or cardio-respiratory arrest and myocardial infarction.[Ref]

Genitourinary

Very common (10% or more): Vaginal hemorrhage (intrathecal)
Uncommon (0.1% to 1%): Hematuria[Ref]

Cardiovascular

Common (1% to 10%): Angina pectoris, chest pain
Uncommon (0.1% to 1%): Arrhythmias, cardiac failure, conduction abnormalities, hypotension, myocardial infarction, flushing, peripheral ischemia.
Rare (0.01% to 0.1%): Hypotension
Very rare (less than 0.01%): Hypertension, ischemia
Frequency not reported: Ventricular hypokinesia, myocardial ischemia, arterial spasm, thrombosis, thrombophlebitis, thrombocytopenia, cardiorespiratory arrest, spasm of coronary arteries, shock[Ref]

Dermatologic

Common (1% to 10%): Nonurticarial rash, erythema, pruritus, rash, urticaria
Uncommon (0.1% to 1%): Hematoma, increased sweating
Very rare (less than 0.01%): Angioedema
Frequency not reported: Severe pustular or bullous skin reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms, drug eruption, dermatitis allergic, skin exfoliation[Ref]

Gastrointestinal

Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Diarrhea, vomiting, dyspepsia
Very rare (less than 0.01%): Abdominal pain, abdominal discomfort
Frequency not reported: Acute pancreatitis, pancreatitis aggravated, salivary gland enlargement[Ref]

Local

Common (1% to 10%): Injection site pain[Ref]

Nervous system

Common (1% to 10%): Headache, migraine, paresthesia
Uncommon (0.1% to 1%): Nervousness, dizziness, sensory disturbance, syncope, parosmia, cerebral vascular disorder, convulsions, hypoesthesia, stupor
Very rare (less than 0.01%): Cerebrovascular accident, amnesia
Frequency not reported: Disturbances in consciousness, coma, motor dysfunction, transient contrast induced encephalopathy (including hallucination), tremor
Postmarketing reports: Dyskinesia[Ref]

Ocular

Common (1% to 10%): Scotoma
Uncommon (0.1% to 1%): Abnormal vision
Frequency not reported: Transient blindness[Ref]

Other

Common (1% to 10%): Vertigo
Uncommon (0.1% to 1%): Edema, fatigue, malaise, tinnitus, feeling hot
Rare (0.01% to 0.1%): Pain, pyrexia, shivering (chills), administration site reactions including
extravasation
Very rare (less than 0.01%): Feeling cold, asthenic conditions
Frequency not reported: Iodism[Ref]

Hypersensitivity

Hypersensitivity reactions usually present as respiratory or cutaneous symptoms like dyspnea, rash, erythema, urticaria, pruritus, skin reaction, angioneurotic edema, hypotension, fever, laryngeal edema, bronchospasm or pulmonary edema. They may appear either immediately after the injection or up to a few days later.
Hypersensitivity reactions may occur irrespectively of the dose and mode of administration and mild symptoms may represent the first signs of a serious anaphylactoid reaction/shock.[Ref]

Uncommon (0.1% to 1%): Pharyngeal edema
Frequency not reported: Anaphylactoid reaction, anaphylactoid shock[Ref]

Psychiatric

Uncommon (0.1% to 1%): Agitation, anxiety, insomnia, confusion[Ref]

Renal

Uncommon (0.1% to 1%): Abnormal renal function, acute renal failure[Ref]

Respiratory

Uncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, pulmonary edema, rhinitis
Rare (less than 0.1%): Cough
Frequency not reported: Non-cardiogenic pulmonary edema, respiratory arrest, respiratory failure
Postmarketing reports: Pulmonary embolism, respiratory depression[Ref]

Musculoskeletal

Rare (less than 0.1%): Back pain
Frequency not reported: Arthralgia
Postmarketing reports: Polymyalgia rheumatica[Ref]

Hematologic

Postmarketing reports: Hemorrhage[Ref]

Metabolic

Postmarketing reports: Hypoglycemia[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Visipaque (iodixanol)." Nycomed Inc, Princeton, NJ.

Some side effects of Visipaque may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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