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Vaprisol Side Effects

Generic name: conivaptan

Medically reviewed by Last updated on Nov 28, 2023.

Note: This document contains side effect information about conivaptan. Some dosage forms listed on this page may not apply to the brand name Vaprisol.

Applies to conivaptan: intravenous solution.

Serious side effects of Vaprisol

Along with its needed effects, conivaptan (the active ingredient contained in Vaprisol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking conivaptan:

More common

Less common

Other side effects of Vaprisol

Some side effects of conivaptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to conivaptan: intravenous solution.


The most frequently reported side effects were infusion site reactions (including phlebitis), pyrexia, hypokalemia, headache, and orthostatic hypotension.[Ref]


Very common (10% or more): Cardiac failure event (32%), orthostatic hypotension (up to 14%)

Common (1% to 10%): Atrial fibrillation, hypertension, hypotension, atrial dysrhythmia[Ref]

During clinical trials, this drug was administered to patients who were hypervolemic and hyponatremic with underlying heart failure. Adverse cardiac failure events (32%), atrial dysrhythmias (5%), and sepsis (8%) occurred more frequently in this patient population treated with this drug compared to those treated with placebo.[Ref]


Very common (10% or more): Infusion site phlebitis (up to 51%), infusion site reaction (up to 22%)

Common (1% to 10%): Infusion site erythema, infusion site pain[Ref]


Very common (10% or more): Hypokalemia (up to 22%)

Common (1% to 10%): Hypomagnesemia, hyponatremia[Ref]


Very common (10% or more): Pyrexia (up to 11%)

Common (1% to 10%): Peripheral edema, thirst, post procedural diarrhea, electrocardiogram ST segment depression, sepsis[Ref]

Nervous system

Very common (10% or more): Headache (up to 10%)

Frequency not reported: Osmotic demyelination syndrome[Ref]


Common (1% to 10%): Constipation, diarrhea, nausea, vomiting[Ref]


Common (1% to 10%): Anemia[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Confusional state, insomnia[Ref]


Common (1% to 10%): Pruritus[Ref]


Common (1% to 10%): Pneumonia, pharyngolaryngeal pain[Ref]


1. Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc. 2006.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.