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Tri-Luma Side Effects

Generic Name: fluocinolone / hydroquinone / tretinoin topical

Note: This page contains side effects data for the generic drug fluocinolone / hydroquinone / tretinoin topical. It is possible that some of the dosage forms included below may not apply to the brand name Tri-Luma.

In Summary

Common side effects of Tri-Luma include: burning sensation, desquamation, pruritus, erythema, and xeroderma. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to fluocinolone / hydroquinone / tretinoin topical: topical application cream

As well as its needed effects, fluocinolone / hydroquinone / tretinoin topical may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking fluocinolone / hydroquinone / tretinoin topical, check with your doctor immediately:

More common:
  • Redness, peeling, drying, itching, or burning of the skin
Less common:
  • Darkening of normal skin color
  • irritated skin
  • rash
Incidence not known:
  • Blistering, crusting, or flaking of the skin
  • burning and itching of the skin with pinhead-sized red blisters
  • lightening of normal skin color
  • redness and scaling around the mouth
  • severe redness, soreness, or scaling of the skin
  • thinning of the skin with easy bruising

Minor Side Effects

Some fluocinolone / hydroquinone / tretinoin topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Blemishes on the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • pimples
  • raised, dark red, wart-like spots on the skin

For Healthcare Professionals

Applies to fluocinolone / hydroquinone / tretinoin topical: topical cream


The most commonly reported side effects included erythema, desquamation, burning, and dryness.[Ref]


Very common (10% or more): Erythema (up to 41%), desquamation (up to 38%), dryness (up to 14%), pruritus (up to 11%)
Common (1% to 10%): Acne, telangiectasia, rosacea, papules, acne-like rash, rash, vesicles, pigmentary changes
Postmarketing reports: Itching, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, miliaria, allergic contact dermatitis[Ref]

Nervous system

Very common (10% or more): Burning (18%)
Common (1% to 10%): Paresthesia[Ref]


Common (1% to 10%): Irritation[Ref]


Common (1% to 10%): Dry mouth[Ref]


1. "Product Information. Tri-Luma (fluocinolone / hydroquinone / tretinoin topical)." Galderma Laboratories Inc, Fort Worth, TX.

It is possible that some side effects of Tri-Luma may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Tri-Luma (fluocinolone / hydroquinone / tretinoin topical)

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