Skip to Content

Thybine Side Effects

Generic Name: yohimbine

Note: This document contains side effect information about yohimbine. Some of the dosage forms listed on this page may not apply to the brand name Thybine.

Applies to yohimbine: compounding powder, oral tablet

Nervous system

Nervous system side effects have included excitation, increased motor activity, tremor, and dizziness.[Ref]


Cardiovascular side effects have included elevation in blood pressure and increase in heart rate.[Ref]


Gastrointestinal side effects have included nausea and vomiting, commonly reported after parenteral administration of yohimbine (the active ingredient contained in Thybine) [Ref]


Psychiatric side effects have included irritability and generalized anxiety.[Ref]


General side effects have included headache and increase in sweating.[Ref]


Dermatologic side effects have included skin flushing reported with oral administration.[Ref]


A severe case of Raynaud's phenomenon has been reported in a 65-year-old man diagnosed with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia). Painful episodes which affected all toes and fingers and his penis lasted 10 to 15 minutes and were relieved with heat. Symptoms resolved slowly over time upon discontinuation of yohimbine (the active ingredient contained in Thybine) Upon rechallenge with yohimbine, the patient developed more severe Raynaud's phenomenon.[Ref]


1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.

Some side effects of Thybine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

More about Thybine (yohimbine)

Consumer resources

Other brands: Yohimbe

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.