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Teduglutide Side Effects

For the Consumer

Applies to teduglutide: subcutaneous powder for solution

As well as its needed effects, teduglutide may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking teduglutide, check with your doctor immediately:

More common:
  • Abdominal or stomach pain
  • decrease in the amount of urine
  • excess air or gas in the stomach or intestines
  • fast heartbeat
  • fever
  • full or bloated feeling
  • hives
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • noisy, rattling breathing
  • pressure in the stomach
  • rash
  • redness of the skin
  • swelling of the abdominal or stomach area
  • swelling of the eyelids, face, lips, hands, or feet
  • swelling of the fingers, hands, feet, or lower legs
  • tightness in the chest
  • troubled breathing at rest
  • troubled breathing or swallowing
  • weight gain
Less common:
  • Indigestion
  • severe nausea or vomiting

Minor Side Effects

Some teduglutide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Body aches or pain
  • changes in appetite
  • chills
  • cough
  • ear congestion
  • headache
  • loss of voice
  • nasal congestion
  • nausea
  • runny nose
  • sneezing
  • sore throat
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to teduglutide: subcutaneous kit

Oncologic

Uncommon (0.1% to 1%): Colorectal polyps
Rare (less than 0.1%): Malignancy[Ref]

Cardiovascular

Very common (10% or more): Fluid overload (up to 11.7%)
Common (1% to 10%): Flushing
Uncommon (0.1% to 1%): Syncope
Rare (less than 0.1%): Congestive heart failure
Postmarketing reports: Cardiac arrest, cardiac failure[Ref]

Gastrointestinal

Very common (10% or more): Gastrointestinal stoma complication (up to 41.9%), abdominal pain (up to 37.7%), nausea (up to 27%), abdominal distension (up to 19.5%), vomiting (up to 14%)
Common (1% to 10%): Pancreatic disease, intestinal obstruction/stenosis, flatulence[Ref]

GI stoma complication (swelling of the stoma and associated complications) is considered a sign of efficacy rather than an adverse event.[Ref]

Hepatic

Common (1% to 10%): Gallbladder and biliary tract disease (cholecystitis, cholangitis, cholelithiasis, cholestasis), increased c-reactive protein[Ref]

Dermatologic

Common (1% to 10%): Skin hemorrhage, allergic dermatitis[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity reaction[Ref]

Immunologic

Very common (10% or more): Antibody formation (up to 48%)
Common (1% to 10%): Influenza

Nervous system

Very common (10% or more): Headache (up to 17%)
Common (1% to 10%): Paresthesia
Postmarketing reports: Cerebral hemorrhage[Ref]

Psychiatric

Common (1% to 10%): Anxiety, sleep disturbance/disorder
Very rare (less than 0.01%): Mental status deterioration[Ref]

Respiratory

Very common (10% or more): Respiratory tract infection (up to 28%)
Common (1% to 10%): Dyspnea, cough[Ref]

Metabolic

Common (1% to 10%): Appetite disorder

Musculoskeletal

Common (1% to 10%): Arthralgia

Other

Very common (10% or more): Injection site reaction (up to 21.8%), peripheral edema (up to 10%)
Common (1% to 10%): Chest pain, night sweats

Renal

Common (1% to 10%): Renal colic, costovertebral angle tenderness

References

1. "Product Information. Gattex (teduglutide)." NPS Pharmaceuticals, Bedminster, NJ.

It is possible that some side effects of teduglutide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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