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Sulfacetamide sodium / urea topical Side Effects

For the Consumer

Applies to sulfacetamide sodium / urea topical: topical lotion, topical pad

Get emergency medical help if you have any of these signs of an allergic reaction while taking sulfacetamide sodium / urea topical: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using sulfacetamide sodium and urea topical and call your doctor at once if you have a serious side effect such as:

  • fever, sore throat, body aches, flu symptoms;

  • mouth sores;

  • easy bruising or bleeding, unusual weakness;

  • dark urine, jaundice (yellowing of the skin or eyes); or

  • warmth, swelling, oozing, or other signs of skin infection; or

  • severe burning, stinging, swelling, or redness of your skin after applying this medicine.

Less serious side effects may include mild skin irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to sulfacetamide sodium / urea topical: topical lotion, topical pad


Hypersensitivity side effects, including irritation, have been reported rarely.

Hypersensitivity side effects associated with sulfonamides, including topical sulfonamides, have included Stevens-Johnson syndrome and toxic epidermal necrolysis. A case of local hypersensitivity which progressed to a fatal syndrome resembling systemic lupus erythematosus has also been reported. Sensitization may recur upon reexposure to sulfonamides by different routes of administration.[Ref]


Hematologic side effects associated with sulfonamides have included agranulocytosis, aplastic anemia, and other blood dyscrasias.[Ref]


Hepatic side effects associated with sulfonamides have included fulminant hepatic necrosis.[Ref]


1. "Product Information. Carmol Scalp (sodium sulfacetamide-urea topical)." Doak Dermatologics Division, Fairfield, NJ.

2. "Product Information. Rosula NS (sodium sulfacetamide-urea topical)." Doak Dermatologics Division, Fairfield, NJ.

Some side effects of sulfacetamide sodium / urea topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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