Smallpox and monkeypox vaccine Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 10, 2023.
Applies to smallpox and monkeypox vaccine: suspension.
Serious side effects
Along with its needed effects, smallpox and monkeypox vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking smallpox and monkeypox vaccine:
Incidence not known
- Chest tightness
- difficulty with swallowing
- fast heartbeat
- hives, itching, rash
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- trouble breathing
- unusual tiredness or weakness
Other side effects
Some side effects of smallpox and monkeypox vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- muscle pain
For Healthcare Professionals
Applies to smallpox and monkeypox vaccine: injectable suspension, subcutaneous suspension.
There were similar proportion of subjects reporting local or systemic reactions of any severity after the second dose, compared to the first dose, except for injection site pain which was more common following dose 1 (79% vs 69%).[Ref]
None of the reported cardiac AESIs causally related to vaccination were considered serious.[Ref]
Common (1% to 10%): Subcutaneous: Cardiac Adverse Events of Special Interest (AESIs - any cardiac signs or symptoms, changes in ECG, or troponin-1 elevations above 2 times the upper limit of normal)[Ref]
Very common (10% or more): Subcutaneous: Nausea (17%); Intradermal: Nausea (23%), change in appetite (20%)[Ref]
Very common (10% or more): Subcutaneous: Pain (85%), redness (60%), swelling (51%), induration (45%), itching (43%); Intradermal: Erythema (99.5%), induration (99.5%), itchiness (89%), pain at injection site (65%), underarm pain (20%), underarm swelling (10%)[Ref]
Very common (10% or more): Subcutaneous: Headache (35%); Intradermal: Headache (41%)[Ref]
Very common (10% or more): Subcutaneous: Fatigue (30%), chills (10%); Intradermal: Tiredness (51%), chills (14%)
Common (1% to 10%): Subcutaneous: Fever[Ref]
More about smallpox and monkeypox vaccine
- Check interactions
- Compare alternatives
- Reviews (1)
- Dosage information
- During pregnancy
- Drug class: viral vaccines
- En español
- Smallpox and monkeypox vaccine drug information
- Smallpox monkeypox vaccine, live non-replicating (Advanced Reading)
Related treatment guides
1. Product Information. Jynneos (smallpox and monkeypox vaccine). Bavarian Nordic, Inc. 2021.
2. FDA. Food and Drug Admnistration. Jynneos Health Care Provider Fact Sheet (Emergency Use Authorization) https://www.fda.gov/media/160774/download 2022.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.