Rsv Vaccine Pref3, Recombinant Side Effects

Medically reviewed by Drugs.com. Last updated on May 1, 2025.

Applies to rsv vaccine pref3, recombinant: intramuscular powder for suspension.

Precautions

Be sure to notify your doctor of any side effects (eg, feeling faint) that occur after you receive this vaccine.

This vaccine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, a fast heartbeat, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the vaccine.

Fainting may occur after you receive this vaccine. You may need to stay for observation after you get the injection to prevent or manage fainting.

Other side effects

Some side effects of rsv vaccine pref3, recombinant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects

Along with its needed effects, rsv vaccine pref3, recombinant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking rsv vaccine pref3, recombinant:

For healthcare professionals

Applies to rsv vaccine pref3, recombinant: intramuscular powder for injection.

General adverse events

The most commonly reported side effects include injection site pain, fatigue, myalgia, and headache.^[Ref]

Cardiovascular

• Very common (10% or more): Swelling (up to 10.4%)
• Frequency not reported: Atrial fibrillation^[Ref]

Dermatologic

• Very common (10% or more): Erythema (up to 13.2%)
• Uncommon (0.1% to 1%): Rash^[Ref]

Gastrointestinal

• Uncommon (0.1% to 1%): Nausea, abdominal pain, vomiting^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Lymphadenopathy^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity reactions^[Ref]

Local

• Very common (10% or more): Injection site pain (up to 75.8%), localized pain (up to 60.9%)
• Common (1% to 10%): Grade 3 localized pain, injection site erythema, localized erythema (greater than 20 mm), injection site swelling, localized swelling (greater than 20 mm)
• Uncommon (0.1% to 1%): Localized erythema (greater than 100 mm), localized swelling (greater than 100 mm), injection site pruritus^[Ref]

Grade 3 localized pain included significant pain at rest and pain that prevented normal everyday activities.^[Ref]

Musculoskeletal

• Very common (10% or more): Myalgia (up to 35.6%), arthralgia (up to 23.4%)
• Common (1% to 10%): Grade 3 myalgia, grade 3 arthralgia, chills^[Ref]

Grade 3 arthralgia and myalgia included events that prevented normal activity.^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 31.7%)
• Common (1% to 10%): Grade 3 headache
• Frequency not reported: Guillain-Barre syndrome^[Ref]

Grade 3 headache included events that prevented normal activity.^[Ref]

Other

• Very common (10% or more): Fatigue (up to 39.8%)
• Common (1% to 10%): Grade 3 fatigue, fever (at least 38C [100.4F])
• Uncommon (0.1% to 1%): Death, fever (over 39C [102.2F]), pain, malaise^[Ref]

Grade 3 fatigue included events that prevented normal activity.

There was no evidence of a causal relationship between this vaccine and death based on available data, as causes of death in the participants were consistent with those generally reported within their age cohort.^[Ref]

Respiratory

• Common (1% to 10%): Rhinorrhea^[Ref]

See also:

Frequently asked questions

• What is the difference between Arexvy and Abrysvo?
• What are the symptoms of RSV (respiratory syncytial virus)?

Further information

Rsv vaccine pref3, recombinant side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer