Skip to Content

Rapivab Side Effects

Generic Name: peramivir

Medically reviewed by Last updated on Aug 30, 2020.

Note: This document contains side effect information about peramivir. Some of the dosage forms listed on this page may not apply to the brand name Rapivab.

For the Consumer

Applies to peramivir: intravenous solution, solution iv (infusion)

Side effects requiring immediate medical attention

Along with its needed effects, peramivir (the active ingredient contained in Rapivab) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking peramivir:

Less common

  • Cloudy urine
  • fever

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • chills
  • confusion as to time, place, or person
  • cough
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, skin rash
  • holding false beliefs that cannot be changed by fact
  • joint or muscle pain
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • seeing, hearing, or feeling things that are not there
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness

Side effects not requiring immediate medical attention

Some side effects of peramivir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Blurred vision
  • constipation
  • difficulty having a bowel movement
  • headache
  • nervousness
  • pounding in the ears
  • redness of the eardrum
  • slow or fast heartbeat
  • trouble sleeping
  • vomiting

For Healthcare Professionals

Applies to peramivir: intravenous solution


Decreased neutrophil count (less than 1 x 10[9]/L) was reported in 8% of patients.[Ref]

Common (1% to 10%): Decreased neutrophil count[Ref]


Common (1% to 10%): Diarrhea, constipation, nausea, vomiting

Uncommon (0.1% to 1%): Upper abdominal pain, abdominal discomfort, gastritis[Ref]


Common (1% to 10%): Elevated serum glucose

Uncommon (0.1% to 1%): Decreased appetite, decreased blood glucose, increased blood uric acid[Ref]

Elevated serum glucose (greater than 160 mg/dL) was reported in 5% of patients.[Ref]


Common (1% to 10%): Elevated creatine phosphokinase

Uncommon (0.1% to 1%): Arthralgia[Ref]

Elevated creatine phosphokinase (at least 6 times the upper limit of normal [6 x ULN]) was reported in 4% of patients.[Ref]


Common (1% to 10%): Increased ALT, increased AST

Uncommon (0.1% to 1%): Increased GGT

Postmarketing reports: Liver disorder[Ref]

Increased ALT (greater than 2.5 x ULN) was reported in 3% of patients.[Ref]


Delirium, hallucinations, and abnormal behavior have been reported in influenza patients using this drug. These side effects were primarily reported in pediatric patients, often with abrupt onset and rapid resolution; the contribution of this drug to such events has not been established.

Psychomotor hyperactivity was common in pediatric patients; this side effect was not reported in adults.[Ref]

Common (1% to 10%): Insomnia

Frequency not reported: Psychomotor hyperactivity

Postmarketing reports: Delirium, abnormal behavior, hallucinations[Ref]


Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): ECG QT prolonged[Ref]


Fever and tympanic membrane erythema were reported in 2% (each) of pediatric patients; these side effects were not reported in adults.[Ref]

Common (1% to 10%): Increased blood lactate dehydrogenase

Uncommon (0.1% to 1%): Decreased blood albumin, increased blood chloride, decreased blood lactate dehydrogenase, increased blood potassium, increased blood sodium, increased total protein, chest discomfort, fatigue

Frequency not reported: Fever/pyrexia, tympanic membrane erythema/hyperemia[Ref]


Postmarketing reports: Anaphylactic/anaphylactoid reactions, anaphylactic shock[Ref]


Pruritus was common in pediatric patients; this side effect was not reported in adults.[Ref]

Uncommon (0.1% to 1%): Dermatitis, drug eruption, eczema, urticaria

Rare (less than 0.1%): Erythema multiforme

Frequency not reported: Serious skin reactions, toxic epidermal necrolysis, pruritus

Postmarketing reports: Stevens-Johnson syndrome, exfoliative dermatitis, rash[Ref]


Uncommon (0.1% to 1%): Blood present in urine, urobilin present in urine, increased urine ketone body

Frequency not reported: Proteinuria[Ref]

Proteinuria (by dipstick analysis) was reported in 3% of pediatric patients; this side effect was not reported in adults.[Ref]


Uncommon (0.1% to 1%): Increased blood urea, increased blood creatinine

Frequency not reported: Acute renal failure, renal failure, prerenal failure, renal disorder, anuria, nephritis

Postmarketing reports: Acute kidney injury, renal impairment

Nervous system

Uncommon (0.1% to 1%): Hypoesthesia, paresthesia


Uncommon (0.1% to 1%): Blurred vision


Frequency not reported: Injection site rash

Injection site rash was common in pediatric patients; this side effect was not reported in adults.


1. "Product Information. Rapivab (peramivir)." BioCryst Pharmaceuticals Inc, Durham, NC.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.