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Provocholine Side Effects

Generic Name: methacholine

Note: This page contains side effects data for the generic drug methacholine. It is possible that some of the dosage forms included below may not apply to the brand name Provocholine.

For the Consumer

Applies to methacholine: inhalation solution

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; itching; lightheadedness; throat irritation.

Seek medical attention right away if any of these SEVERE side effects occur while taking methacholine (the active ingredient contained in Provocholine)

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; cough; fainting; severe dizziness; wheezing.

For Healthcare Professionals

Applies to methacholine: compounding powder, inhalation powder for reconstitution


When administered orally or by injection, this drug is reported to cause nausea, vomiting, substernal pain or pressure, hypotension, fainting, and transient complete heart block. Overdosage with this drug, when administered orally or by injection, can result in a syncopal reaction with cardiac arrest and loss of consciousness. This drug should be administered only by inhalation.[Ref]

Nervous system

Very rare (less than 0.01%): Headache, lightheadedness[Ref]


Very rare (less than 0.01%): Itching[Ref]


Very rare (less than 0.01%): Throat irritation[Ref]


1. "Product Information. Provocholine (methacholine)." Methapharm Inc, Brantford, ON.

It is possible that some side effects of Provocholine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.