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Methacholine Pregnancy and Breastfeeding Warnings

Methacholine is also known as: Provocholine

Methacholine Pregnancy Warnings

Animal studies have not been conducted. There are no controlled data in human pregnancy. The background birth defect and miscarriage risk for the indicated population is not known. In the US general population, the estimated major birth defect risk is 2 to 4% and the miscarriage risk is 15 to 20%.

US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.

Use is not recommended.

US FDA pregnancy category: Not assigned

Comments:
-Available data on use in pregnant women is insufficient to know this drugs risks, including the risk of fetal harm or reproductive effects.
-Use of bronchoprovocation challenge to diagnose bronchial airway hyperreactivity is not recommended during pregnancy because of the potential for hypoxia.
-Consider empiric treatment of suspected bronchial airway hyperreactivity.

See references

Methacholine Breastfeeding Warnings

The manufacturer makes no recommendation regarding use during lactation.

Excreted into human milk: Unknown
Excreted into animal milk: Data not available

Comments:
-There is no information regarding this drug on the presence in human milk, the effects on a breastfed infant, or effects on milk production.
-Consider the developmental and health benefits of breastfeeding along with the mother's clinical need for this medication as well as any potential adverse effects from this drug or the underlying maternal condition.

See references

References for pregnancy information

  1. "Product Information. Provocholine (methacholine)." Methapharm Inc, Brantford, ON.

References for breastfeeding information

  1. "Product Information. Provocholine (methacholine)." Methapharm Inc, Brantford, ON.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.