Pralidoxime Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 22, 2024.

Applies to pralidoxime: injection powder for solution.

Precautions

Your doctor will check your progress closely while you or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

Call your doctor right away if you or your child have fast heartbeat, difficulty or trouble with breathing, increased muscle weakness, or severe tiredness after receiving this medicine.

This medicine will add to the effects of CNS depressants (medicines that may make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of pralidoxime

Along with its needed effects, pralidoxime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pralidoxime:

Other side effects of pralidoxime

Some side effects of pralidoxime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to pralidoxime: intravenous powder for injection.

Cardiovascular adverse events

• Frequency not reported: Tachycardia, increased systolic and diastolic blood pressure^[Ref]

Musculoskeletal

• Frequency not reported: Muscular weakness^[Ref]

Nervous system

• Frequency not reported: Drowsiness^[Ref]

Respiratory

• Frequency not reported: Hyperventilation^[Ref]

Ocular

• Frequency not reported: Blurred vision, diplopia, impaired accommodation^[Ref]

Gastrointestinal

• Frequency not reported: Nausea^[Ref]

Metabolic

• Frequency not reported: Transient elevations of creatine phosphokinase

Hepatic

• Frequency not reported: Elevations in SGOT and/or SGPT enzymes^[Ref]

SGOT and SGPT levels returned to normal after about 2 weeks.^[Ref]

Local

• Frequency not reported: Pain at the injection site^[Ref]

Mild to moderate pain at the injection site occurs 40 to 60 minutes after intramuscular injection.^[Ref]

See also:

Further information

Pralidoxime side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer