Physostigmine Ophthalmic Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 27, 2025.

Applies to physostigmine ophthalmic: ophthalmic ointment.

Contact your doctor immediately if you notice any decrease in vision or an increase in "floaters” in your visual field. Rarely, physostigmine ophthalmic may cause retinal detachment . Retinal detachment can lead to blind spots, floaters in your visual field, and even blindness. Your doctor will want to check your retina before you use this medication to determine if you have an increased risk of retinal detachment.

If you experience any of the following serious side effects, stop using physostigmine ophthalmic and seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; shortness of breath; swelling of the lips, face, or tongue; or hives);

• abdominal cramps or diarrhea;

• watering mouth;

• excessive sweating;

• urinary incontinence;

• muscle weakness;

• difficulty breathing; or

• an irregular heart beat.

Other, less serious side effects may be more likely to occur. Continue to use physostigmine ophthalmic and talk to your doctor if you experience

• burning, stinging, red, or tearing eyes;

• eyelid muscle twitches;

• headache or brow ache; or

• decreased vision in poor light.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

See also:

Further information

Physostigmine ophthalmic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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