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Paricalcitol Side Effects

Medically reviewed by Last updated on May 22, 2023.

Applies to paricalcitol: oral capsule liquid filled. Other dosage forms:

Serious side effects of Paricalcitol

Along with its needed effects, paricalcitol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking paricalcitol:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking paricalcitol:

Symptoms of overdose

Other side effects of Paricalcitol

Some side effects of paricalcitol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to paricalcitol: intravenous solution, oral capsule.


The most common adverse events were nausea, diarrhea, and elevated calcium phosphate product.[Ref]


Very common (10% or more): Nausea (12.9%), diarrhea (11.5%)

Common (1% to 10%): Vomiting, constipation, gastrointestinal hemorrhage, abdominal discomfort, dry mouth, gastroenteritis, stomach discomfort, gastroesophageal reflux disease

Uncommon (0.1% to 1%): Rectal hemorrhage, colitis, gastritis, dyspepsia, dysphagia, abdominal pain, gastrointestinal disorder

Frequency not reported: Intestinal ischemia, gastrointestinal hemorrhage[Ref]


Very common (10% or more): Elevated calcium phosphate product (12%)

Common (1% to 10%): Fluid overload, hypoglycemia, dehydration, hypercalcemia, hypocalcemia, decreased appetite, hyperphosphatemia

Uncommon (0.1% to 1%): Hyperkalemia, anorexia, thirst[Ref]


Common (1% to 10%): Hypertension, hypotension, palpitations

Uncommon (0.1% to 1%): Cardiac arrest, arrhythmia, atrial flutter

Frequency not reported: Irregular heart rate[Ref]

Nervous system

Common (1% to 10%): Vertigo, dizziness, headache, syncope, dysgeusia

Uncommon (0.1% to 1%): Coma, cerebrovascular accident, transient ischemic attack, myoclonus, hypoesthesia, paresthesia, gait disturbance

Frequency not reported: Unresponsive to stimuli[Ref]


Common (1% to 10%): Nasopharyngitis, pneumonia, influenza, oropharyngeal pain, sinusitis, cough

Uncommon (0.1% to 1%): Pulmonary edema, asthma, dyspnea, epistaxis, pharyngitis

Frequency not reported: Upper respiratory tract infection, orthopnea, wheezing[Ref]


Common (1% to 10%): Viral infection, edema, peritonitis, chills, pyrexia, pain, fatigue, peripheral edema, malaise, chest pain, fungal infection, infection

Uncommon (0.1% to 1%): Laboratory test abnormal, decreased weight, ear disorder, condition aggravated, asthenia

Frequency not reported: Phosphorous increased, ear discomfort, chest discomfort, feeling abnormal, swelling[Ref]


Common (1% to 10%): Hypersensitivity

Postmarketing reports: Allergic reactions including rash, urticaria, and angioedema (including laryngeal edema)[Ref]


Common (1% to 10%): Rash, pruritus, skin ulcer, acne

Uncommon (0.1% to 1%): Urticaria, bullous dermatitis, alopecia, hirsutism, hyperhidrosis

Frequency not reported: Blister, night sweats, rash pruritic, skin burning sensation[Ref]


Common (1% to 10%): Hypoparathyroidism

Uncommon (0.1% to 1%): Hyperparathyroidism[Ref]


Common (1% to 10%): Urinary tract infection, breast tenderness

Uncommon (0.1% to 1%): Vaginal infection, breast pain, erectile dysfunction[Ref]


Common (1% to 10%): Chills, arthralgia, arthritis, back pain, muscle spasms

Uncommon (0.1% to 1%): Joint stiffness, muscle twitching, myalgia[Ref]


Common (1% to 10%): Renal failure chronic

Uncommon (0.1% to 1%): Blood creatinine increased[Ref]


Common (1% to 10%): Sepsis[Ref]


Common (1% to 10%): Insomnia, anxiety, depression

Uncommon (0.1% to 1%): Confusional state, delirium, depersonalization, agitation, nervousness

Frequency not reported: Restlessness[Ref]


Uncommon (0.1% to 1%): Bleeding time prolonged, anemia, leukopenia, lymphadenopathy[Ref]


Uncommon (0.1% to 1%): Hepatic enzyme abnormal, increased aspartate aminotransferase

Frequency not reported: Alkaline phosphatase decreased[Ref]


Uncommon (0.1% to 1%): Conjunctivitis, glaucoma

Frequency not reported: Ocular hyperemia[Ref]


Uncommon (0.1% to 1%): Breast cancer[Ref]


Uncommon (0.1% to 1%): Injection site pain

Frequency not reported: Injection site extravasation[Ref]


1. Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.