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MZM Side Effects

Generic Name: methazolamide

Note: This page contains information about the side effects of methazolamide. Some of the dosage forms included on this document may not apply to the brand name MZM.

For the Consumer

Applies to methazolamide: oral tablet

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blood in urine or stools;

  • a seizure (convulsions);

  • loss of movement in any part of your body;

  • a blood cell disorder--sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, pale skin, feeling tired or short of breath, rapid heart rate, nosebleeds, bleeding gums;

  • liver problems--nausea, upper stomach pain or swelling, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • signs of metabolic acidosis--confusion, vomiting, lack of energy, irregular heartbeats;

  • signs of a kidney stone--pain in your side or lower back, blood in your urine, painful or difficult urination; or

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • nausea, vomiting, loss of appetite, diarrhea;

  • numbness or tingling, especially in your arms and legs;

  • drowsiness, confusion;

  • hearing problems, ringing in your ears;

  • increased urination; or

  • altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to methazolamide: compounding powder, oral tablet

Nervous system

Frequency not reported: Paresthesias, hearing dysfunction or tinnitus, taste alteration, drowsiness, flaccid paralysis, convulsions[Ref]


Frequency not reported: Gastrointestinal disturbances, nausea, vomiting, diarrhea, melena[Ref]


Frequency not reported: Polyuria, glycosuria, crystalluria[Ref]


Frequency not reported: Loss of appetite, metabolic acidosis, electrolyte imbalance[Ref]


Frequency not reported: Urticaria, photosensitivity[Ref]


Frequency not reported: Fatigue, malaise[Ref]


Frequency not reported: Hepatic insufficiency[Ref]


Frequency not reported: Sulfonamide reactions[Ref]


Frequency not reported: Transient myopia[Ref]


Frequency not reported: Confusion[Ref]


Frequency not reported: Renal calculi[Ref]


1. "Product Information. Neptazane (methazolamide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Not all side effects for MZM may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about MZM (methazolamide)

Consumer resources

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.