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Mumpsvax Side Effects

Generic Name: mumps virus vaccine

Note: This page contains information about the side effects of mumps virus vaccine. Some of the dosage forms included on this document may not apply to the brand name Mumpsvax.

For the Consumer

Applies to mumps virus vaccine: subcutaneous injectable, subcutaneous powder for solution

In addition to its needed effects, some unwanted effects may be caused by mumps virus vaccine (the active ingredient contained in Mumpsvax). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking mumps virus vaccine:

Symptoms of allergic reaction
  • Difficulty in breathing or swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Severity: Moderate

If any of the following side effects occur while taking mumps virus vaccine, check with your doctor or nurse as soon as possible:

  • Bruising or purple spots on skin
  • confusion
  • fever over 103 °F (39.4 °C)
  • headache (severe or continuing)
  • irritability
  • pain, tenderness, or swelling in testicles and scrotum (in adolescent boys and men)
  • stiff neck
  • vomiting

Minor Side Effects

Some of the side effects that can occur with mumps virus vaccine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Burning or stinging at place of injection
Less common or rare:
  • Fever of 100 °F (37.7 °C) or less
  • itching, swelling, redness, tenderness, or hard lump at place of injection
  • skin rash
  • swollen glands on side of face or neck

For Healthcare Professionals

Applies to mumps virus vaccine: subcutaneous powder for injection


Local side effects have included burning/stinging at the injection site and wheal and flare.[Ref]


Hypersensitivity reactions have included anaphylaxis, anaphylactoid reactions, angioneurotic edema (including peripheral or facial edema), and bronchial spasm.[Ref]


Cardiovascular side effects have included vasculitis.[Ref]


Dermatologic side effects have included Stevens-Johnson Syndrome, erythema multiforme, and urticaria.[Ref]


Endocrine side effects have included diabetes mellitus.[Ref]


Genitourinary side effects have included orchitis.[Ref]


Gastrointestinal side effects have included pancreatitis; diarrhea, and parotitis.[Ref]


Hematologic side effects have included thrombocytopenia, purpura, lymphadenopathy, and leukocytosis.[Ref]

Nervous system

Nervous system side effects have included encephalitis, Guillain-Barré Syndrome (GBS), febrile seizures, ocular palsies, and aseptic meningitis.[Ref]

Although a causal relationship between the Urabe strain of mumps vaccine and aseptic meningitis has been shown, there are no data that associate the currently used Jeryl Lynn vaccine strain to aseptic meningitis.[Ref]


Ocular side effects have included optic neuritis, papillitis, retrobulbar neuritis, and conjunctivitis.[Ref]


Respiratory side effects have included cough and rhinitis.[Ref]


Otic side effects have included nerve deafness and otitis media.[Ref]

Other side effects have included fever, syncope, and irritability.

Fatalities have been reported following administration of the polyvalent measles/mumps/rubella vaccine; however, causality has not been determined.

Health care providers should report any allergic or unusual adverse reactions to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967 (USA) and the manufacturer.[Ref]

A postmarketing surveillance study in Finland during 1982 to 1993 with 1.5 million pediatric and adult vaccinees (measles/mumps/rubella vaccine) reported no deaths or permanent sequelae.[Ref]


1. "Product Information. Mumpsvax (mumps virus vaccine (live).)." Merck & Co, Inc, West Point, PA.

Not all side effects for Mumpsvax may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.