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Methacholine Side Effects

For the Consumer

Applies to methacholine: inhalation solution reconstituted

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Shortness of breath.
  • Wheezing or coughing.
  • Very bad dizziness or passing out.
  • Very upset stomach or throwing up.
  • Chest pain or pressure.
  • A heartbeat that does not feel normal.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to methacholine: compounding powder, inhalation powder for reconstitution

General

When administered orally or by injection, this drug is reported to cause nausea, vomiting, substernal pain or pressure, hypotension, fainting, and transient complete heart block. Overdosage with this drug, when administered orally or by injection, can result in a syncopal reaction with cardiac arrest and loss of consciousness. This drug should be administered only by inhalation.[Ref]

Nervous system

Very rare (less than 0.01%): Headache, lightheadedness[Ref]

Dermatologic

Very rare (less than 0.01%): Itching[Ref]

Gastrointestinal

Very rare (less than 0.01%): Throat irritation[Ref]

References

1. "Product Information. Provocholine (methacholine)." Methapharm Inc, Brantford, ON.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about methacholine

Consumer resources

Other brands: Provocholine

Professional resources

Related treatment guides

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