Mepsevii Side Effects
Generic name: vestronidase alfa
Medically reviewed by Drugs.com. Last updated on Feb 5, 2025.
Note: This document provides detailed information about Mepsevii Side Effects associated with vestronidase alfa. Some dosage forms listed on this page may not apply specifically to the brand name Mepsevii.
Applies to vestronidase alfa: intravenous solution.
Important warnings
This medicine can cause some serious health issues
Intravenous route (solution)
Anaphylaxis has occurred with vestronidase alfa-vjbk administration, as early as the first dose, therefore appropriate medical support should be readily available when vestronidase alfa-vjbk is administered.
Closely observe patients during and for 60 minutes after vestronidase alfa-vjbk infusion.
Immediately discontinue the vestronidase alfa-vjbk infusion if the patient experiences anaphylaxis.
Precautions
It is very important that your doctor check your progress to make sure that this medicine is working properly and to check for unwanted effects.
This medicine may cause a serious allergic reaction, called anaphylaxis. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine.
Serious side effects of Mepsevii
Along with its needed effects, vestronidase alfa (the active ingredient contained in Mepsevii) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking vestronidase alfa:
Rare side effects
- bloating or swelling of the face, arms, hands, lower legs, or feet
- cough
- difficulty swallowing
- dizziness
- fast heartbeat
- hives, itching, skin rash
- pale skin, pain, or redness at the injection site
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- tightness in the chest
- tingling of the hands or feet
- unusual tiredness or weakness
- unusual weight gain or loss
Incidence not known
- fever with seizures
Other side effects of Mepsevii
Some side effects of vestronidase alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Rare side effects
- diarrhea
- swelling at the injection site
See also:
For healthcare professionals
Applies to vestronidase alfa: intravenous solution.
General adverse events
The most frequently reported side effects were infusion site extravasation, diarrhea, rash, anaphylaxis, infusion site swelling, peripheral swelling, and pruritus.[Ref]
Immunologic
- Very common (10% or more): Anti-drug antibodies developed (78%), neutralizing antibodies developed (55.6%), anaphylaxis (16.67%)[Ref]
Nervous system
- Frequency not reported: Febrile convulsion[Ref]
A week 66 of treatment, 1 patient experiences a febrile convulsion during infusion of a 4 mg/kg dose. The infusion was stopped and the patient was given anticonvulsants, antipyretics, and antibiotics and the adverse reaction resolved. The patient was subsequently rechallenged without recurrence and continued on treatment with this drug.[Ref]
Dermatologic
- Very common (10% or more): Rash (25%)
- Common (1% to 10%): Pruritus[Ref]
Gastrointestinal
- Very common (10% or more): Diarrhea (25%)[Ref]
Other
- Common (1% to 10%): Peripheral swelling[Ref]
Local
- Very common (10% or more): Infusion site extravasation (33.3%)
- Common (1% to 10%): Infusion site swelling[Ref]
References
1. (2017) "Product Information. Mepsevii (vestronidase alfa)." Ultragenyx Pharmaceutical
Frequently asked questions
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Further information
Mepsevii side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.