Mepsevii Side Effects

Generic name: vestronidase alfa

Medically reviewed by Drugs.com. Last updated on May 11, 2024.

Note: This document provides detailed information about Mepsevii Side Effects associated with vestronidase alfa. Some dosage forms listed on this page may not apply specifically to the brand name Mepsevii.

Applies to vestronidase alfa: intravenous solution.

Important warnings This medicine can cause some serious health issues

Intravenous route (solution)

Anaphylaxis has occurred with vestronidase alfa-vjbk administration, as early as the first dose, therefore appropriate medical support should be readily available when vestronidase alfa-vjbk is administered.

Closely observe patients during and for 60 minutes after vestronidase alfa-vjbk infusion.

Immediately discontinue the vestronidase alfa-vjbk infusion if the patient experiences anaphylaxis.

Serious side effects of Mepsevii

Along with its needed effects, vestronidase alfa (the active ingredient contained in Mepsevii) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking vestronidase alfa:

Rare side effects

• bloating or swelling of the face, arms, hands, lower legs, or feet
• cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives, itching, skin rash
• pale skin, pain, or redness at the injection site
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rapid weight gain
• tightness in the chest
• tingling of the hands or feet
• unusual tiredness or weakness
• unusual weight gain or loss

Incidence not known

• fever with seizures

Other side effects of Mepsevii

Some side effects of vestronidase alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare side effects

• diarrhea
• swelling at the injection site

For healthcare professionals

Applies to vestronidase alfa: intravenous solution.

General adverse events

The most frequently reported side effects were infusion site extravasation, diarrhea, rash, anaphylaxis, infusion site swelling, peripheral swelling, and pruritus.^[Ref]

Immunologic

• Very common (10% or more): Anti-drug antibodies developed (78%), neutralizing antibodies developed (55.6%), anaphylaxis (16.67%)^[Ref]

Nervous system

• Frequency not reported: Febrile convulsion^[Ref]

A week 66 of treatment, 1 patient experiences a febrile convulsion during infusion of a 4 mg/kg dose. The infusion was stopped and the patient was given anticonvulsants, antipyretics, and antibiotics and the adverse reaction resolved. The patient was subsequently rechallenged without recurrence and continued on treatment with this drug.^[Ref]

Dermatologic

• Very common (10% or more): Rash (25%)
• Common (1% to 10%): Pruritus^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (25%)^[Ref]

Other

• Common (1% to 10%): Peripheral swelling^[Ref]

Local

• Very common (10% or more): Infusion site extravasation (33.3%)
• Common (1% to 10%): Infusion site swelling^[Ref]

Frequently asked questions

• What is Mepsevii used to treat?

Further information

Mepsevii side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer