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Liquid PedvaxHIB Side Effects

Generic name: haemophilus b conjugate (prp-omp) vaccine

Note: This document contains side effect information about haemophilus b conjugate (prp-omp) vaccine. Some dosage forms listed on this page may not apply to the brand name Liquid PedvaxHIB.

Applies to haemophilus b conjugate (prp-omp) vaccine: intramuscular suspension.


Tell your doctor if your child uses other medicines or have other medical conditions or allergies.

Get emergency medical help if your child has signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects.

Call your doctor at once if your child has:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to haemophilus b conjugate (prp-omp) vaccine: intramuscular suspension.


The most common adverse events were irritability, sleepiness, injections site pain/soreness, injection site swelling, unusual high-pitched crying, prolonged crying (over 4 hours), diarrhea, vomiting, crying, pain, otitis media, rash, and upper respiratory infection.[Ref]


Very common (10% or more): Fever over 38.3C (rectal) (18.1%)

Common (1% to 10%): Unusual high-pitched crying, prolonged crying (over 4 hours), crying, pain[Ref]


Common (1% to 10%): Diarrhea, vomiting

Frequency not reported: Urticaria[Ref]


Common (1% to 10%): Erythema over 2.5 cm diameter, swelling over 2.5 cm diameter, injection site pain/soreness

Postmarketing reports: Sterile injection site abscess[Ref]


Common (1% to 10%): Irritability, sleepiness[Ref]


Common (1% to 10%): Rash

Postmarketing reports: Angioedema[Ref]


Common (1% to 10%): Otitis media, upper respiratory infection[Ref]

Nervous system

Postmarketing reports: Febrile seizures[Ref]


Frequency not reported: Thrombocytopenia[Ref]


Frequency not reported: Tracheitis[Ref]


1. (2022) "Product Information. Liquid PedvaxHIB (haemophilus b conjugate (PRP-OMP) vaccine)." Merck & Co., Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.