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Liposyn II Side Effects

Generic name: fat emulsion

Medically reviewed by Drugs.com. Last updated on Aug 26, 2022.

Note: This document contains side effect information about fat emulsion. Some of the dosage forms listed on this page may not apply to the brand name Liposyn II.

For the Consumer

Applies to fat emulsion: intravenous emulsion

Side effects requiring immediate medical attention

Along with its needed effects, fat emulsion (the active ingredient contained in Liposyn II) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fat emulsion:

More common

Less common

  • Bladder pain
  • bloody or cloudy urine
  • chills
  • confusion
  • difficult, burning, or painful urination
  • dizziness
  • fainting
  • fever
  • frequent urge to urinate
  • headache
  • lower back or side pain
  • nervousness
  • pale skin
  • pounding in the ears
  • rapid, shallow breathing
  • slow or fast heartbeat
  • unusual bleeding or bruising

Rare

  • Chest pain or tightness
  • changes in skin color
  • clay-colored stools
  • cough
  • dark urine
  • eye pain
  • general feeling of illness
  • itching, skin rash
  • loss of appetite
  • pain, tenderness, or swelling of the foot or leg
  • sneezing
  • sore throat
  • unpleasant breath odor
  • vomiting of blood
  • yellow eyes or skin

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • bluish color
  • difficulty in swallowing
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • pinpoint red spots on the skin
  • problems with bleeding or clotting
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, throat, or tongue
  • swollen glands
  • upper right abdominal or stomach pain and fullness

Side effects not requiring immediate medical attention

Some side effects of fat emulsion may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Acid or sour stomach
  • belching
  • bloated
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • indigestion
  • passing gas
  • stomach discomfort or upset

Rare

  • Change in taste
  • loss of taste

Incidence not known

  • Increased sweating

For Healthcare Professionals

Applies to fat emulsion: intravenous emulsion

Hepatic

Common (1% to 10%): Cholestasis, blood bilirubin increased

Uncommon (0.1% to 1%): Cytolytic hepatitis, cholecystitis, cholelithiasis, liver function test abnormalities, pancreatic enzyme increased

Frequency not reported: Increased gamma-glutamyltransferase, hepatomegaly, jaundice due to central lobular cholestasis, transient increases in liver function tests[Ref]

Hematologic

Common (1% to 10%): Anemia

Uncommon (0.1% to 1%): Leukopenia

Rare (less than 0.1%): Thrombocytopenia in neonates

Frequency not reported: Leukocytosis, hypercoagulability, splenomegaly, thrombocytopenia[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, mean arterial pressure decreased

Uncommon (0.1% to 1%): Circulatory collapse, hypotension, hot flush

Frequency not reported: Tachycardia, thrombophlebitis, cyanosis, flushing, arrhythmia[Ref]

Hypersensitivity

Frequency not reported: Allergic reaction, hypersensitivity[Ref]

Immunologic

Common (1% to 10%): Sepsis, device related infection

Frequency not reported: Pneumonia, infection, septicemia[Ref]

Other

Common (1% to 10%): Pyrexia

Frequency not reported: Increased blood alkaline phosphatase, increased C-reactive protein, increase in temperature, pain in chest and back, slight pressure over the eyes, overloading syndrome (focal seizures, fever, leukocytosis, hepatomegaly, splenomegaly, and shock), intravenous fat pigment (deposition of brown pigmentation in the reticuloendothelial system), increased blood level of immunosuppressant drug, asthenia, malaise

Postmarketing reports: International normalized ration decreased[Ref]

Nervous system

Frequency not reported: Dysgeusia, headache, dizziness, sleepiness, cerebral edema, convulsion[Ref]

Musculoskeletal

Common (1% to 10%): Muscle spasms

Uncommon (0.1% to 1%): Back pain, chills

Frequency not reported: Bone necrosis

Respiratory

Frequency not reported: Respiratory insufficiency[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, flatulence, abdominal pain, dyspepsia, abdominal distension, epigastric discomfort

Frequency not reported: Diarrhea[Ref]

Dermatologic

Frequency not reported: Pruritus, rash, sweating[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Local

Frequency not reported: Irritation at sight of infusion[Ref]

Metabolic

Common (1% to 10%): Hyperglycemia, blood triglycerides increased, hyperproteinemia, hyperlipidemia

Frequency not reported: Hyperlipemia, diabetes mellitus inadequate control, hypoproteinemia[Ref]

More about Liposyn II (fat emulsion)

Patient resources

Other brands

SMOFlipid, Omegaven, Intralipid, Clinolipid, Nutrilipid

Professional resources

Related treatment guides

References

1. "Product Information. Intralipid (fat emulsion, intravenous)." Baxter I.V. Systems Division (2018):

2. "Product Information. Smoflipid (fat emulsion, intravenous)." Fresenius Kabi USA, LLC (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.