Lioresal Intrathecal Side Effects
Generic name: baclofen
Medically reviewed by Drugs.com. Last updated on May 30, 2024.
Note: This document provides detailed information about Lioresal Intrathecal.
For healthcare professionals
Applies to baclofen: compounding powder, intrathecal solution, oral granule, oral liquid, oral solution, oral suspension, oral tablet Side Effects associated with baclofen. Some dosage forms listed on this page may not apply specifically to the brand name Lioresal Intrathecal.
For healthcare professionals
Applies to baclofen: compounding powder, intrathecal solution, oral granule, oral liquid, oral solution, oral suspension, oral tablet.
Cardiovascular
- Common (1% to 10%): Cardiac output decreased, hypotension, hypertension, diminished cardiovascular functions, peripheral edema
- Rare (less than 0.1%): Arrhythmias, palpitations, chest pain
- Frequency not reported: Bradycardia, orthostatic hypotension[Ref]
Dermatologic
- Common (1% to 10%): Rash, hyperhidrosis, urticaria/pruritus, facial edema
- Uncommon (0.1% to 1%): Alopecia, diaphoresis
- Frequency not reported: Rash, sweating, contact dermatitis, skin ulcer[Ref]
Endocrine
- Common (1% to 10%): Ovarian cysts are palpable in 4% of women treated with for up to one year[Ref]
Gastrointestinal
- Very common (10% or more): Nausea (especially at start of therapy) (up to 11%)
- Common (1% to 10%): Dry mouth, GI disorder/disturbance, constipation, diarrhea, retching, vomiting, increased salivation
- Uncommon (0.1% to 1%): Dysphagia, dehydration, ileus, decreased taste sensation
- Rare (less than 0.1%): Colicky abdominal pain, anorexia
- Frequency not reported: GI hemorrhage[Ref]
Genitourinary
- Very common (10% or more): Urinary retention (up to 12%)
- Common (1% to 10%): Urinary incontinence, urination impaired, sexual dysfunction, urinary frequency, enuresis, dysuria
- Rare (less than 0.1%): Erectile dysfunction
- Frequency not reported: Dysuria, abnormal ejaculation, oliguria, vaginitis[Ref]
Hematologic
- Frequency not reported: Leukocytosis, petechial rash[Ref]
Hepatic
- Rare (less than 0.1%): Disorders of hepatic function (e.g., increased AST)[Ref]
Immunologic
Metabolic
- Common (1% to 10%): Decreased appetite
- Frequency not reported: Blood glucose increased[Ref]
Musculoskeletal
- Very common (10% or more): Hypotonia (up to 52%), lower extremity weakness (up to 15%), disturbances of gait and balance
- Common (1% to 10%): Muscular weakness, myalgia, upper extremity weakness, back pain, muscular hypertonia[Ref]
Nervous system
- Very common (10% or more): Somnolence (up to 28%), drowsiness (up to 18%), headache (up to 16%), seizures (especially on discontinuation of therapy) (up to 15%), sedation, dizziness (up to 12%)
- Common (1% to 10%): Fatigue, ataxia, tremor, lightheadedness, lassitude, exhaustion, numbness/itching/tingling, slurred speech, lethargy, hypertonia, paresthesia
- Rare (less than 0.1%): Dysarthria, dysgeusia, syncope, dyskinesia, coma, potentially life-threatening withdrawal symptoms (as a result of sudden interruption of drug delivery)[Ref]
Other
- Common (1% to 10%): Tinnitus, pain, asthenia
- Uncommon (0.1% to 1%): Accidental injury, weight loss
- Very rare (less than 0.01%): Hypothermia
- Frequency not reported: Drug withdrawal syndrome
- Uncommon (0.1% to 1%): Subdural hemorrhage, accidental injury, weight loss[Ref]
Ocular
- Common (1% to 10%): Nystagmus, visual impairment, accommodation disorder, blurred vision, double vision, amblyopia[Ref]
Psychiatric
- Common (1% to 10%): Confusional state, hallucination, depression, insomnia, euphoric mood, nightmare, personality changes
- Uncommon (0.1% to 1%): Memory loss/impairment, suicidal ideation, attempted suicide
- Rare (less than 0.1%): Excitement[Ref]
Renal
- Very rare (less than 0.01%): Kidney calculus[Ref]
Respiratory
- Common (1% to 10%): Respiratory depression, hypoventilation, dyspnea, bradypnea, feeling of pressure in the chest[Ref]
References
1. (2001) "Product Information. Lioresal (baclofen)." Medtronic Neurological
2. (2001) "Product Information. Lioresal Intrathecal (baclofen)." Medtronic Neurological
3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
4. Pharmaceutical Society of Australia (2006) APPGuide online. Australian prescription products guide online. http://www.appco.com.au/appguide/default.asp
More about Lioresal Intrathecal (baclofen)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (3)
- Dosage information
- During pregnancy
- Drug class: skeletal muscle relaxants
- Breastfeeding
Patient resources
Other brands
Fleqsuvy, Ozobax, Gablofen, Lyvispah, Ozobax DS
Professional resources
Other brands
Fleqsuvy, Ozobax, Gablofen, Lyvispah, Ozobax DS
Other formulations
Related treatment guides
Further information
Lioresal Intrathecal side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.