Lioresal Intrathecal Side Effects
Generic name: baclofen
Medically reviewed by Drugs.com. Last updated on Feb 28, 2024.
Note: This document contains side effect information about baclofen. Some dosage forms listed on this page may not apply to the brand name Lioresal Intrathecal.
For Healthcare Professionals
Applies to baclofen: compounding powder, intrathecal solution, oral granule, oral liquid, oral solution, oral suspension, oral tablet.
Cardiovascular
Common (1% to 10%): Cardiac output decreased, hypotension, hypertension, diminished cardiovascular functions, peripheral edema
Rare (less than 0.1%): Arrhythmias, palpitations, chest pain
Frequency not reported: Bradycardia, orthostatic hypotension[Ref]
Dermatologic
Common (1% to 10%): Rash, hyperhidrosis, urticaria/pruritus, facial edema
Uncommon (0.1% to 1%): Alopecia, diaphoresis
Frequency not reported: Rash, sweating, contact dermatitis, skin ulcer[Ref]
Endocrine
Common (1% to 10%): Ovarian cysts are palpable in 4% of women treated with for up to one year[Ref]
Gastrointestinal
Very common (10% or more): Nausea (especially at start of therapy) (up to 11%)
Common (1% to 10%): Dry mouth, GI disorder/disturbance, constipation, diarrhea, retching, vomiting, increased salivation
Uncommon (0.1% to 1%): Dysphagia, dehydration, ileus, decreased taste sensation
Rare (less than 0.1%): Colicky abdominal pain, anorexia
Frequency not reported: GI hemorrhage[Ref]
Genitourinary
Very common (10% or more): Urinary retention (up to 12%)
Common (1% to 10%): Urinary incontinence, urination impaired, sexual dysfunction, urinary frequency, enuresis, dysuria
Rare (less than 0.1%): Erectile dysfunction
Frequency not reported: Dysuria, abnormal ejaculation, oliguria, vaginitis[Ref]
Hematologic
Frequency not reported: Leukocytosis, petechial rash[Ref]
Hepatic
Rare (less than 0.1%): Disorders of hepatic function (e.g., increased AST)[Ref]
Immunologic
Common (1% to 10%): Pneumonia
Uncommon (0.1% to 1%): Septicemia[Ref]
Metabolic
Common (1% to 10%): Decreased appetite
Frequency not reported: Blood glucose increased[Ref]
Musculoskeletal
Very common (10% or more): Hypotonia (up to 52%), lower extremity weakness (up to 15%), disturbances of gait and balance
Common (1% to 10%): Muscular weakness, myalgia, upper extremity weakness, back pain, muscular hypertonia[Ref]
Nervous system
Very common (10% or more): Somnolence (up to 28%), drowsiness (up to 18%), headache (up to 16%), seizures (especially on discontinuation of therapy) (up to 15%), sedation, dizziness (up to 12%)
Common (1% to 10%): Fatigue, ataxia, tremor, lightheadedness, lassitude, exhaustion, numbness/itching/tingling, slurred speech, lethargy, hypertonia, paresthesia
Rare (less than 0.1%): Dysarthria, dysgeusia, syncope, dyskinesia, coma, potentially life-threatening withdrawal symptoms (as a result of sudden interruption of drug delivery)[Ref]
Other
Common (1% to 10%): Tinnitus, pain, asthenia
Uncommon (0.1% to 1%): Accidental injury, weight loss
Very rare (less than 0.01%): Hypothermia
Frequency not reported: Drug withdrawal syndrome
Uncommon (0.1% to 1%): Subdural hemorrhage, accidental injury, weight loss[Ref]
Ocular
Common (1% to 10%): Nystagmus, visual impairment, accommodation disorder, blurred vision, double vision, amblyopia[Ref]
Psychiatric
Common (1% to 10%): Confusional state, hallucination, depression, insomnia, euphoric mood, nightmare, personality changes
Uncommon (0.1% to 1%): Memory loss/impairment, suicidal ideation, attempted suicide
Rare (less than 0.1%): Excitement[Ref]
Renal
Very rare (less than 0.01%): Kidney calculus[Ref]
Respiratory
Common (1% to 10%): Respiratory depression, hypoventilation, dyspnea, bradypnea, feeling of pressure in the chest[Ref]
More about Lioresal Intrathecal (baclofen)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (3)
- Side effects
- Dosage information
- During pregnancy
- Drug class: skeletal muscle relaxants
- Breastfeeding
Patient resources
Other brands
Gablofen, Ozobax, Fleqsuvy, Lyvispah, Ozobax DS
Professional resources
Other brands
Gablofen, Ozobax, Fleqsuvy, Lyvispah, Ozobax DS
Other formulations
Related treatment guides
References
1. Product Information. Lioresal (baclofen). Medtronic Neurological. 2001;PROD.
2. Product Information. Lioresal Intrathecal (baclofen). Medtronic Neurological. 2001;PROD.
3. Cerner Multum, Inc. UK Summary of Product Characteristics.
4. Pharmaceutical Society of Australia. APPGuide online. Australian prescription products guide online. http://www.appco.com.au/appguide/default.asp 2006.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.