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Idarucizumab Side Effects

For the Consumer

Applies to idarucizumab: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by idarucizumab. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking idarucizumab, check with your doctor or nurse immediately:

Incidence not known:
  • Anxiety
  • blurred vision
  • bone pain
  • chills
  • cold sweats
  • coma
  • confusion
  • convulsions
  • cool, pale skin
  • cough
  • dark-colored urine
  • deep or fast breathing with dizziness
  • depression
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • drowsiness
  • fast heartbeat
  • fever
  • general feeling of tiredness or weakness
  • headache
  • hives, itching, or skin rash
  • increased hunger
  • light-colored stools
  • loss of appetite
  • muscle tremors
  • nausea
  • nervousness
  • nightmares
  • numbness of the feet, hands, and around the mouth
  • pain in the chest, groin, or legs, especially the calves
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid, deep breathing
  • restlessness
  • seizures
  • severe, sudden headache
  • shakiness
  • slurred speech
  • stomach cramps
  • stomach pain, continuing
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • tightness in the chest
  • unusual tiredness or weakness
  • vision changes
  • vomiting
  • yellow eyes or skin

For Healthcare Professionals

Applies to idarucizumab: intravenous solution


The most common adverse reactions were hypokalemia, delirium, constipation, pyrexia, pneumonia, and headache.[Ref]


Common (1% to 10%): Thrombotic events[Ref]


Common (1% to 10%): Hypokalemia[Ref]


Common (1% to 10%): Delirium[Ref]


Common (1% to 10%): Constipation[Ref]


Common (1% to 10%): Pyrexia[Ref]


Common (1% to 10%): Pneumonia
Frequency not reported: Bronchospasm, hyperventilation[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Frequency not reported: Rash, pruritus[Ref]


Frequency not reported: Hypersensitivity reactions[Ref]


1. "Product Information. Praxbind (idaruCIZUMAB)." Boehringer Ingelheim, Ridgefield, CT.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for idarucizumab may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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