Idarucizumab Side Effects
Medically reviewed by Drugs.com. Last updated on Mar 15, 2025.
Applies to idarucizumab: intravenous solution.
Precautions
Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly. Blood tests will be needed to check for unwanted effects.
This medicine may increase your risk of blood clots. Tell your doctor if you have the following symptoms: pain in the chest, groin, or legs, especially the calves, difficulty with breathing, severe, sudden headache, slurred speech, sudden, unexplained shortness of breath, sudden loss of coordination, sudden, severe weakness or numbness in the arm or leg, or vision changes.
This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving this medicine.
This medicine may cause serious side effects in patients with hereditary fructose intolerance. Tell your doctor right away if you have increased hunger, cold sweats, blurred vision, fast heartbeat, shakiness, trembling, stomach pain, dark urine or light colored stools, unusual tiredness or weakness, or yellow eyes or skin.
Serious side effects of idarucizumab
Along with its needed effects, idarucizumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking idarucizumab:
Incidence not known
- anxiety
- blurred vision
- bone pain
- chills
- cold sweats
- coma
- confusion
- convulsions
- cool, pale skin
- cough
- dark-colored urine
- deep or fast breathing with dizziness
- depression
- difficulty with breathing
- difficulty with swallowing
- dizziness
- drowsiness
- fast heartbeat
- fever
- general feeling of tiredness or weakness
- headache
- hives, itching, or skin rash
- increased hunger
- light-colored stools
- loss of appetite
- muscle tremors
- nausea
- nervousness
- nightmares
- numbness of the feet, hands, and around the mouth
- pain in the chest, groin, or legs, especially the calves
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid, deep breathing
- restlessness
- seizures
- severe, sudden headache
- shakiness
- slurred speech
- stomach cramps
- stomach pain, continuing
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- sudden, unexplained shortness of breath
- tightness in the chest
- unusual tiredness or weakness
- vision changes
- vomiting
- yellow eyes or skin
For healthcare professionals
Applies to idarucizumab: intravenous solution.
General adverse events
The most common adverse reactions were hypokalemia, delirium, constipation, pyrexia, pneumonia, and headache.[Ref]
Cardiovascular
- Common (1% to 10%): Thrombotic events[Ref]
Metabolic
- Common (1% to 10%): Hypokalemia[Ref]
Psychiatric
- Common (1% to 10%): Delirium[Ref]
Gastrointestinal
- Common (1% to 10%): Constipation, nausea[Ref]
Other
- Common (1% to 10%): Pyrexia[Ref]
Respiratory
- Common (1% to 10%): Pneumonia
- Frequency not reported: Bronchospasm, hyperventilation[Ref]
Nervous system
- Common (1% to 10%): Headache[Ref]
Dermatologic
Immunologic
- Frequency not reported: Hypersensitivity reactions[Ref]
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References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
2. (2016) "Product Information. Praxbind (idarucizumab)." Boehringer Ingelheim
More about idarucizumab
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Further information
Idarucizumab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.