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Hespan Side Effects

Generic Name: hetastarch

Note: This document contains side effect information about hetastarch. Some of the dosage forms listed on this page may not apply to the brand name Hespan.

For the Consumer

Applies to hetastarch: parenteral injection

Side effects include:

Hypersensitivity reactions, coagulopathy, hemodilution, circulatory overload, metabolic acidosis, CHF, pulmonary edema, bleeding, vomiting, peripheral edema, submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headache, muscle pain.

For Healthcare Professionals

Applies to hetastarch: intravenous solution


Frequency not reported: Circulatory overload, congestive heart failure, pulmonary edema, peripheral edema of the lower extremities[Ref]


Frequency not reported: Vomiting[Ref]


Frequency not reported: Intracranial bleeding, bleeding and/or anemia due to hemodilution and/or Factor VIII deficiency, acquired von Willebrand's-like syndrome, coagulopathy (including rare cases of disseminated intravascular coagulopathy and hemolysis)[Ref]


Frequency not reported: Death, life-threatening anaphylactic/anaphylactoid reactions, cardiac arrest, ventricular fibrillation, severe hypotension, non-cardiac pulmonary edema, laryngeal edema, bronchospasm, angioedema, wheezing, restlessness, tachypnea, stridor, fever, chest pain, bradycardia, tachycardia, shortness of breath, chills, urticaria, pruritus, facial and periorbital edema, coughing, sneezing, flushing erythema multiforme, rash[Ref]


Frequency not reported: Metabolic acidosis[Ref]


Frequency not reported: Muscle pains[Ref]


Frequency not reported: Submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headaches, hydroxyethyl starch-associated pruritus in patients with deposits of hydroxyethyl starch in peripheral nerves[Ref]


1. "Product Information. Hespan (hetastarch)." B. Braun Medical, Irvine, CA.

2. "Product Information. Hextend (hetastarch)." Abbott Pharmaceutical, Abbott Park, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Hespan (hetastarch)

Consumer resources

Other brands: Hextend

Professional resources

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