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Hespan Side Effects

Generic name: hetastarch

Medically reviewed by Last updated on Mar 29, 2024.

Note: This document contains side effect information about hetastarch. Some dosage forms listed on this page may not apply to the brand name Hespan.

Applies to hetastarch: intravenous solution.


Intravenous route (Solution)

Warning: Mortality; Kidney Injury; CoagulopathyUse of hydroxyethylstarch (HES) products, including hetastarch/sodium chloride, increases risk of mortality, kidney injury, and coagulopathy. Do not use hydroxyethylstarch (HES) products, including hetastarch/sodium chloride, unless adequate alternative treatment is unavailable.

Serious side effects of Hespan

Along with its needed effects, hetastarch (the active ingredient contained in Hespan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hetastarch:

Incidence not known

Other side effects of Hespan

Some side effects of hetastarch may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to hetastarch: intravenous solution.


Frequency not reported: Circulatory overload, congestive heart failure, pulmonary edema, peripheral edema of the lower extremities[Ref]


Frequency not reported: Vomiting[Ref]


Frequency not reported: Intracranial bleeding, bleeding and/or anemia due to hemodilution and/or Factor VIII deficiency, acquired von Willebrand's-like syndrome, coagulopathy (including rare cases of disseminated intravascular coagulopathy and hemolysis)[Ref]


Frequency not reported: Death, life-threatening anaphylactic/anaphylactoid reactions, cardiac arrest, ventricular fibrillation, severe hypotension, non-cardiac pulmonary edema, laryngeal edema, bronchospasm, angioedema, wheezing, restlessness, tachypnea, stridor, fever, chest pain, bradycardia, tachycardia, shortness of breath, chills, urticaria, pruritus, facial and periorbital edema, coughing, sneezing, flushing erythema multiforme, rash[Ref]


Frequency not reported: Metabolic acidosis[Ref]


Frequency not reported: Muscle pain[Ref]


Frequency not reported: Submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headaches, hydroxyethyl starch-associated pruritus in patients with deposits of hydroxyethyl starch in peripheral nerves[Ref]


Frequency not reported: Pulmonary edema[Ref]


-The most common adverse reactions are hypersensitivity, coagulopathy, hemodilution, circulatory overload and metabolic acidosis.

-Serious adverse events reported in clinical trials are increased mortality and renal replacement therapy in critically ill patients.[Ref]


Frequency not reported: Need for renal replacement therapy[Ref]


1. Product Information. Hextend (hetastarch). Abbott Pharmaceutical. 2013.

2. Product Information. Hespan (hetastarch). B. Braun Medical. 2013.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.