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Fluocinolone / hydroquinone / tretinoin topical Side Effects

Medically reviewed by Last updated on Jun 23, 2023.

Applies to fluocinolone/hydroquinone/tretinoin topical: topical application cream.

Serious side effects

Along with its needed effects, fluocinolone/hydroquinone/tretinoin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluocinolone / hydroquinone / tretinoin topical:

More common

Less common

Incidence not known

Other side effects

Some side effects of fluocinolone / hydroquinone / tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to fluocinolone / hydroquinone / tretinoin topical: topical cream.


The most commonly reported side effects included erythema, desquamation, burning, and dryness.[Ref]


Very common (10% or more): Erythema (up to 41%), desquamation (up to 38%), dryness (up to 14%), pruritus (up to 11%)

Common (1% to 10%): Acne, telangiectasia, rosacea, papules, acne-like rash, rash, vesicles, pigmentary changes

Postmarketing reports: Itching, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, miliaria, allergic contact dermatitis[Ref]

Nervous system

Very common (10% or more): Burning (18%)

Common (1% to 10%): Paresthesia[Ref]


Common (1% to 10%): Irritation[Ref]


Common (1% to 10%): Dry mouth[Ref]


1. Product Information. Tri-Luma (fluocinolone / hydroquinone / tretinoin topical). Galderma Laboratories Inc. 2003.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.