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Eliglustat Side Effects

In Summary

Commonly reported side effects of eliglustat include: arthralgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eliglustat: oral capsule

Along with its needed effects, eliglustat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eliglustat:

Less Common

  • Fast, irregular, pounding, or racing heartbeat or pulse

Incidence Not Known

Get emergency help immediately if any of the following symptoms of overdose occur while taking eliglustat:

Symptoms of Overdose

  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nausea
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
  • vomiting

Some side effects of eliglustat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Acid or sour stomach
  • back pain
  • belching
  • bloated
  • cough
  • diarrhea
  • difficulty with moving
  • excess air or gas in the stomach or intestines
  • full feeling
  • headache
  • heartburn
  • indigestion
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in the arms or legs
  • pain in the joints
  • passing gas
  • sore throat
  • stomach discomfort, upset, or pain
  • upper abdominal or stomach pain

Less Common

  • Difficulty having a bowel movement (stool)
  • rash

For Healthcare Professionals

Applies to eliglustat: oral capsule

Cardiovascular

Common (1% to 10%): Palpitations[Ref]

Dermatologic

Common (1% to 10%): Rash[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 12%), diarrhea (up to 12%), oropharyngeal pain (up to 10%)

Common (1% to 10%): Flatulence, dyspepsia, gastroesophageal reflux disease, constipation[Ref]

General

The most frequently reported side effects (occurring in 10% or more of patients) included fatigue, headache, nausea, diarrhea, back pain, pain in extremities, and upper abdominal pain.[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (up to 45%), back pain (up to 12%), pain in extremity (up to 11%), upper abdominal pain (up to 10%)

Common (1% to 10%): Asthenia[Ref]

Nervous system

Very common (10% or more): Headache (up to 40%), migraine (up to 10%)

Common (1% to 10%): Dizziness[Ref]

Other

Very common (10% or more): Fatigue (up to 14%)[Ref]

Respiratory

Common (1% to 10%): Cough[Ref]

References

1. "Product Information. Cerdelga (eliglustat)." Genzyme Corporation, Cambridge, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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