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Eliglustat Side Effects

Medically reviewed by Last updated on Sep 18, 2022.


Commonly reported side effects of eliglustat include: arthralgia. Continue reading for a comprehensive list of adverse effects.

Applies to eliglustat: oral capsule.

Serious side effects of Eliglustat

Along with its needed effects, eliglustat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eliglustat:

Less common

  • Fast, irregular, pounding, or racing heartbeat or pulse

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking eliglustat:

Symptoms of overdose

  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nausea
  • sweating
  • unusual tiredness or weakness
  • vomiting

Other side effects of Eliglustat

Some side effects of eliglustat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • belching
  • bloated
  • cough
  • diarrhea
  • difficulty with moving
  • excess air or gas in the stomach or bowels
  • full feeling
  • headache
  • heartburn
  • indigestion
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in the arms or legs
  • pain in the joints
  • passing gas
  • sore throat
  • stomach discomfort, upset, or pain
  • upper abdominal or stomach pain

Less common

  • Difficulty having a bowel movement
  • rash

For Healthcare Professionals

Applies to eliglustat: oral capsule.


Common (1% to 10%): Palpitations[Ref]


Common (1% to 10%): Rash[Ref]


Very common (10% or more): Nausea (up to 12%), diarrhea (up to 12%), oropharyngeal pain (up to 10%)

Common (1% to 10%): Flatulence, dyspepsia, gastroesophageal reflux disease, constipation[Ref]


The most frequently reported side effects (occurring in 10% or more of patients) included fatigue, headache, nausea, diarrhea, back pain, extremity pain, and upper abdominal pain.[Ref]


Very common (10% or more): Arthralgia (up to 45%), back pain (up to 12%), pain in extremity (up to 11%), upper abdominal pain (up to 10%)[Ref]

Nervous system

Very common (10% or more): Headache (up to 40%), migraine (up to 10%)

Common (1% to 10%): Dizziness, asthenia[Ref]


Very common (10% or more): Fatigue (up to 14%)[Ref]


Common (1% to 10%): Cough[Ref]


1. "Product Information. Cerdelga (eliglustat)." Genzyme Corporation (2014):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.