Skip to Content

Eliglustat Side Effects

For the Consumer

Applies to eliglustat: oral capsule

In addition to its needed effects, some unwanted effects may be caused by eliglustat. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking eliglustat:

Less common:
  • Fast, irregular, pounding, or racing heartbeat or pulse
Incidence not known:
  • Dizziness
  • fainting

If any of the following symptoms of overdose occur while taking eliglustat, get emergency help immediately:

Symptoms of overdose:
  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nausea
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
  • vomiting

Minor Side Effects

Some of the side effects that can occur with eliglustat may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • back pain
  • belching
  • bloated
  • cough
  • diarrhea
  • difficulty with moving
  • excess air or gas in the stomach or intestines
  • full feeling
  • headache
  • heartburn
  • indigestion
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in the arms or legs
  • pain in the joints
  • passing gas
  • sore throat
  • stomach discomfort, upset, or pain
  • upper abdominal or stomach pain
Less common:
  • Difficulty having a bowel movement (stool)
  • rash

For Healthcare Professionals

Applies to eliglustat: oral capsule


Common (1% to 10%): Palpitations[Ref]


Common (1% to 10%): Rash[Ref]


Very common (10% or more): Nausea (up to 12%), diarrhea (up to 12%), oropharyngeal pain (up to 10%)
Common (1% to 10%): Flatulence, dyspepsia, gastroesophageal reflux disease, constipation[Ref]


The most frequently reported side effects (occurring in 10% or more of patients) included fatigue, headache, nausea, diarrhea, back pain, pain in extremities, and upper abdominal pain.[Ref]


Very common (10% or more): Arthralgia (up to 45%), back pain (up to 12%), pain in extremity (up to 11%), upper abdominal pain (up to 10%)
Common (1% to 10%): Asthenia[Ref]

Nervous system

Very common (10% or more): Headache (up to 40%), migraine (up to 10%)
Common (1% to 10%): Dizziness[Ref]


Very common (10% or more): Fatigue (up to 14%)[Ref]


Common (1% to 10%): Cough[Ref]


1. "Product Information. Cerdelga (eliglustat)." Genzyme Corporation, Cambridge, MA.

Not all side effects for eliglustat may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.