Eliglustat Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 11, 2024.

Applies to eliglustat: oral capsule.

Common side effects of eliglustat

Some side effects of eliglustat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• back pain
• belching
• bloated
• cough
• diarrhea
• difficulty with moving
• excess air or gas in the stomach or bowels
• full feeling
• headache
• heartburn
• indigestion
• lack or loss of strength
• muscle pain or stiffness
• pain in the arms or legs
• pain in the joints
• passing gas
• sore throat
• stomach discomfort, upset, or pain
• upper abdominal or stomach pain

Less common side effects

• difficulty having a bowel movement
• rash

Serious side effects of eliglustat

Along with its needed effects, eliglustat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eliglustat:

Less common side effects

• fast, irregular, pounding, or racing heartbeat or pulse

Incidence not known

• dizziness
• fainting

Get emergency help immediately if any of the following symptoms of overdose occur while taking eliglustat:

Symptoms of overdose

• blurred vision
• chest pain or discomfort
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• nausea
• sweating
• unusual tiredness or weakness
• vomiting

For healthcare professionals

Applies to eliglustat: oral capsule.

General adverse events

The most frequently reported side effects (occurring in 10% or more of patients) included fatigue, headache, nausea, diarrhea, back pain, extremity pain, and upper abdominal pain.^[Ref]

Dermatologic

• Common (1% to 10%): Rash^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 12%), diarrhea (up to 12%), oropharyngeal pain (up to 10%)
• Common (1% to 10%): Flatulence, dyspepsia, gastroesophageal reflux disease, constipation^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitations^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (up to 45%), back pain (up to 12%), pain in extremity (up to 11%), upper abdominal pain (up to 10%)^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 40%), migraine (up to 10%)
• Common (1% to 10%): Dizziness, asthenia^[Ref]

Other

• Very common (10% or more): Fatigue (up to 14%)^[Ref]

Respiratory

• Common (1% to 10%): Cough^[Ref]

Further information

Eliglustat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer