Eliglustat Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 10, 2024.
Applies to eliglustat: oral capsule.
Precautions
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
Common side effects of eliglustat
Some side effects of eliglustat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- back pain
- belching
- bloated
- cough
- diarrhea
- difficulty with moving
- excess air or gas in the stomach or bowels
- full feeling
- headache
- heartburn
- indigestion
- lack or loss of strength
- muscle pain or stiffness
- pain in the arms or legs
- pain in the joints
- passing gas
- sore throat
- stomach discomfort, upset, or pain
- upper abdominal or stomach pain
Less common side effects
- difficulty having a bowel movement
- rash
Serious side effects of eliglustat
Along with its needed effects, eliglustat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking eliglustat:
Less common side effects
- fast, irregular, pounding, or racing heartbeat or pulse
Incidence not known
- dizziness
- fainting
Get emergency help immediately if any of the following symptoms of overdose occur while taking eliglustat:
Symptoms of overdose
- blurred vision
- chest pain or discomfort
- confusion
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- nausea
- sweating
- unusual tiredness or weakness
- vomiting
For healthcare professionals
Applies to eliglustat: oral capsule.
General adverse events
The most frequently reported side effects (occurring in 10% or more of patients) included fatigue, headache, nausea, diarrhea, back pain, extremity pain, and upper abdominal pain.[Ref]
Dermatologic
- Common (1% to 10%): Rash[Ref]
Gastrointestinal
- Very common (10% or more): Nausea (up to 12%), diarrhea (up to 12%), oropharyngeal pain (up to 10%)
- Common (1% to 10%): Flatulence, dyspepsia, gastroesophageal reflux disease, constipation[Ref]
Cardiovascular
- Common (1% to 10%): Palpitations[Ref]
Musculoskeletal
- Very common (10% or more): Arthralgia (up to 45%), back pain (up to 12%), pain in extremity (up to 11%), upper abdominal pain (up to 10%)[Ref]
Nervous system
- Very common (10% or more): Headache (up to 40%), migraine (up to 10%)
- Common (1% to 10%): Dizziness, asthenia[Ref]
Other
- Very common (10% or more): Fatigue (up to 14%)[Ref]
Respiratory
- Common (1% to 10%): Cough[Ref]
See also:
Cerdelga
Cerdelga (eliglustat) is used to treat mild to moderate Type 1 Gaucher Disease. Includes Cerdelga ...
VPRIV
VPRIV (velaglucerase alfa) is used as an enzyme replacement in people with Type I Gaucher disease ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Zavesca
Zavesca is used in the treatment of mild to moderate type 1 Gaucher disease. Learn about side ...
Cerezyme
Cerezyme is a man-made form of an enzyme that occurs naturally in the body. It is used as an enzyme ...
Miglustat
Miglustat systemic is used for gaucher disease, niemann-pick disease, pompe disease
Imiglucerase
Imiglucerase systemic is used for gaucher disease, thrombocytopenia
Velaglucerase alfa
Velaglucerase alfa systemic is used for gaucher disease
References
1. (2014) "Product Information. Cerdelga (eliglustat)." Genzyme Corporation
More about eliglustat
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Further information
Eliglustat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.