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Doxercalciferol Side Effects

Medically reviewed by Last updated on Jun 3, 2023.

Applies to doxercalciferol: oral capsule liquid filled. Other dosage forms:

Serious side effects of Doxercalciferol

Along with its needed effects, doxercalciferol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking doxercalciferol:

More common

Incidence not known

Other side effects of Doxercalciferol

Some side effects of doxercalciferol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to doxercalciferol: intravenous solution, oral capsule.


Very common (10% or more): Edema (34.4%)

Common (1% to 10%): Anorexia, weight increase, dehydration

Frequency not reported: Hypercalcemia, hyperphosphatemia, hypercalciuria[Ref]

Early signs and symptoms of hypercalcemia have included weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia.

Prolonged hypercalcemia may result in polyuria, polydipsia, anorexia, weight loss, nocturia conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated blood urea nitrogen (BUN), albuminuria, hypercholesterolemia, elevated serum aspartate transaminase (AST) and alanine transaminase (ALT), ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.

Hyperphosphatemia may exacerbate hyperparathyroidism.

Hypercalciuria may accelerate the onset of renal failure.[Ref]


Oversuppression of iPTH may result in adynamic bone syndrome.[Ref]

Frequency not reported: Oversuppression of parathyroid hormone[Ref]


Common (1% to 10%): Bradycardia, chest pain[Ref]


Very common (10% or more): Nausea/vomiting (21.3%)

Common (1% to 10%): Dyspepsia, constipation[Ref]


Common (1% to 10%): Arthralgia[Ref]

Nervous system

Very common (10% or more): Headache (27.9%), dizziness (11.5%)

Common (1% to 10%): Hypertonia, paresthesia[Ref]


Common (1% to 10%): Pruritus[Ref]


Very common (10% or more): Dyspnea (11.5%)

Common (1% to 10%): Cough increased, rhinitis[Ref]


Very common (10% or more): Malaise (27.9%)

Common (1% to 10%): Abscess[Ref]


Common (1% to 10%): Sleep disorder, depression

Uncommon (0.1% to 1%): Insomnia[Ref]


Common (1% to 10%): Infection


Postmarketing reports: Hypersensitivity reactions (including fatal outcome)

Hypersensitivity reactions include anaphylaxis with symptoms of angioedema (involving face, lips, tongue, and airway), hypotension, unresponsiveness, chest discomfort, shortness of breath, cardiopulmonary arrest, pruritus, and skin burning sensation. These reactions may occur separately or together.


Common (1% to 10%): Anemia[Ref]


1. Product Information. Hectorol (doxercalciferol). Genzyme Corporation. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.