Doxercalciferol Side Effects
Medically reviewed by Drugs.com. Last updated on Feb 1, 2021.
For the Consumer
Applies to doxercalciferol: oral capsules, parenteral injection
Side effects include:
Excessive vitamin D intake (late manifestations): Polyuria, polydipsia anorexia, weight loss, nocturia, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, increased BUN, albuminuria, hypercholesterolemia, increased serum AST and ALT concentrations, ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, growth arrest, urinary tract infections.
For Healthcare Professionals
Applies to doxercalciferol: intravenous solution, oral capsule
Very common (10% or more): Edema (34.4%)
Common (1% to 10%): Anorexia, weight increase, dehydration
Early signs and symptoms of hypercalcemia have included weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia.
Prolonged hypercalcemia may result in polyuria, polydipsia, anorexia, weight loss, nocturia conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated blood urea nitrogen (BUN), albuminuria, hypercholesterolemia, elevated serum aspartate transaminase (AST) and alanine transaminase (ALT), ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.
Hyperphosphatemia may exacerbate hyperparathyroidism.
Hypercalciuria may accelerate the onset of renal failure.[Ref]
Oversuppression of iPTH may result in adynamic bone syndrome.[Ref]
Frequency not reported: Oversuppression of parathyroid hormone[Ref]
Common (1% to 10%): Bradycardia, chest pain[Ref]
Very common (10% or more): Nausea/vomiting (21.3%)
Common (1% to 10%): Dyspepsia, constipation[Ref]
Common (1% to 10%): Arthralgia[Ref]
Very common (10% or more): Headache (27.9%), dizziness (11.5%)
Common (1% to 10%): Hypertonia, paresthesia[Ref]
Common (1% to 10%): Pruritus[Ref]
Very common (10% or more): Dyspnea (11.5%)
Common (1% to 10%): Cough increased, rhinitis[Ref]
Very common (10% or more): Malaise (27.9%)
Common (1% to 10%): Abscess[Ref]
Common (1% to 10%): Sleep disorder, depression
Uncommon (0.1% to 1%): Insomnia[Ref]
Common (1% to 10%): Infection
Postmarketing reports: Hypersensitivity reactions (including fatal outcome)
Hypersensitivity reactions include anaphylaxis with symptoms of angioedema (involving face, lips, tongue, and airway), hypotension, unresponsiveness, chest discomfort, shortness of breath, cardiopulmonary arrest, pruritus, and skin burning sensation. These reactions may occur separately or together.
Common (1% to 10%): Anemia[Ref]
1. "Product Information. Hectorol (doxercalciferol)" Genzyme Corporation, Cambridge, MA.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.