Doxercalciferol Side Effects
For the Consumer
Applies to doxercalciferol: oral capsules, parenteral injection
Side effects include:
Excessive vitamin D intake (late manifestations): polyuria, polydipsia anorexia, weight loss, nocturia, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, increased BUN, albuminuria, hypercholesterolemia, increased serum AST and ALT concentrations, ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, growth arrest, urinary tract infections.
For Healthcare Professionals
Applies to doxercalciferol: injectable solution, oral capsule
Early signs and symptoms of hypercalcemia have included weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia.
Prolonged hypercalcemia may result in polyuria, polydipsia, anorexia, weight loss, nocturia conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated blood urea nitrogen (BUN), albuminuria, hypercholesterolemia, elevated serum aspartate transaminase (AST) and alanine transaminase (ALT), ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.
Hyperphosphatemia may exacerbate hyperparathyroidism.
Hypercalciuria may accelerate the onset of renal failure.[Ref]
Very common (10% or more): Edema (34.4%)
Common (1% to 10%): Anorexia, weight increase, dehydration
Frequency not reported: Hypercalcemia, hyperphosphatemia, hypercalciuria[Ref]
Oversuppression of iPTH may result in adynamic bone syndrome.[Ref]
Common (1% to 10%): Bradycardia, chest pain[Ref]
Very common (10% or more): Nausea/vomiting (21.3%)
Common (1% to 10%): Dyspepsia, constipation[Ref]
Common (1% to 10%): Arthralgia[Ref]
Very common (10% or more): Headache (27.9%), dizziness (11.5%)
Common (1% to 10%): Hypertonia, paresthesia[Ref]
Common (1% to 10%): Pruritus[Ref]
Very common (10% or more): Dyspnea (11.5%)
Common (1% to 10%): Cough increased, rhinitis[Ref]
Very common (10% or more): Malaise (27.9%)
Common (1% to 10%): Abscess[Ref]
Common (1% to 10%): Sleep disorder, depression
Uncommon (0.1% to 1%): Insomnia[Ref]
Common (1% to 10%): Infection
Hypersensitivity reactions include anaphylaxis with symptoms of angioedema (involving face, lips, tongue, and airway), hypotension, unresponsiveness, chest discomfort, shortness of breath, cardiopulmonary arrest, pruritus, and skin burning sensation. These reactions may occur separately or together.
Postmarketing reports: Hypersensitivity reactions (including fatal outcome)
Common (1% to 10%): Anemia[Ref]
1. "Product Information. Hectorol (doxercalciferol)" Genzyme Corporation, Cambridge, MA.
Some side effects of doxercalciferol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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- Drug class: vitamins
Other brands: Hectorol
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