Cyclopentolate / Phenylephrine Ophthalmic Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 17, 2025.

Applies to cyclopentolate / phenylephrine ophthalmic: ophthalmic solution.

Important warnings This medicine can cause some serious health issues

You should not receive this medicine if you have untreated narrow-angle glaucoma.

Get emergency medical help if you have any of these signs of an allergic reaction while taking cyclopentolate / phenylephrine ophthalmic: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• blurred vision, tunnel vision, or seeing halos around lights;

• eye pain;

• fast heart rate, severe headache, pounding in your neck or ears, anxiety;

• fever;

• little or no urinating;

• flushing (warmth, redness, or tingly feeling);

• severe constipation; or

• weak or shallow breathing.

Infants and children may be more likely to have side effects from cyclopentolate and phenylephrine ophthalmic. Tell the doctor if the child has:

• confusion, changes in behavior, hallucinations;

• speech problems, trouble recognizing people;

• restless or excited behavior;

• loss of balance or coordination;

• seizure (convulsions); or

• feeding problems or loss of appetite.

Common side effects may include:

• dry mouth, nose, or throat;

• decreased sweating; or

• sensitivity to sunlight.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Further information

Cyclopentolate/phenylephrine ophthalmic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer