Corifact Side Effects
Generic name: factor XIII
Medically reviewed by Drugs.com. Last updated on Jul 31, 2024.
Note: This document provides detailed information about Corifact.
Applies to factor XIII: intravenous powder for solution Side Effects associated with factor XIII. Some dosage forms listed on this page may not apply specifically to the brand name Corifact.
Applies to factor XIII: intravenous powder for solution.
Precautions
It is very important that your doctor check you or your child closely while you are receiving this medicine to make sure it is working properly. Blood tests may be needed to check for unwanted effects.
This medicine may cause serious type of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you or your child have a cough, difficulty with swallowing, dizziness, a fast heartbeat, lightheadedness or fainting, trouble breathing, chest tightness, swelling in your face, hands, tongue, or throat, a fever, chills, a runny nose or sneezing, itching or hives, or lightheadedness or faintness after you receive the medicine.
This medicine may increase your chance of having blood clotting problems. Tell your doctor right away if you or your child have a sudden or severe headache, problems with vision or speech, chest pain, shortness of breath, or numbness or weakness while you are receiving this medicine.
Corifact™ is made from human blood. Some human blood products have transmitted certain viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor about this risk if you are concerned.
Serious side effects of Corifact
Along with its needed effects, factor XIII (the active ingredient contained in Corifact) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking factor XIII:
More common side effects
- bloody nose
- bruise
- collection of blood under the skin
- deep, dark purple bruise
- fever
- itching, pain, redness, or swelling
Incidence not known
- chest pain
- cough
- dizziness or fainting
- hives
- pain in the chest, groin, or legs, especially the calves
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, scaly, swollen, or peeling areas of the skin
- severe, sudden headache
- shortness of breath
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
- unusual tiredness or weakness
Other side effects of Corifact
Some side effects of factor XIII may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- difficulty with moving
- general feeling of discomfort or illness
- headache
- joint pain
- muscle aches and pains
For healthcare professionals
Applies to factor XIII: intravenous powder for injection.
Hypersensitivity adverse events
- Common (1% to 10%): Hypersensitivity
- Uncommon (0.1% to 1%): Serious hypersensitivity[Ref]
Cardiovascular
- Uncommon (0.1% to 1%): Acute ischemia[Ref]
Immunologic
- Common (1% to 10%): Elevated thrombin-antithrombin levels
- Uncommon (0.1% to 1%): Neutralizing antibodies against factor XIII[Ref]
Musculoskeletal
- Common (1% to 10%): Joint inflammation, arthralgia[Ref]
Dermatologic
Nervous system
- Common (1% to 10%): Headache[Ref]
Metabolic
- Common (1% to 10%): Increased blood lactate dehydrogenase[Ref]
See also:
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Adzynma
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Alphanine SD
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References
1. (2022) "Product Information. Corifact (factor XIII)." CSL Behring LLC
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Further information
Corifact side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.