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Ciprodex Side Effects

Generic Name: ciprofloxacin / dexamethasone otic

Note: This page contains information about the side effects of ciprofloxacin / dexamethasone otic. Some of the dosage forms included on this document may not apply to the brand name Ciprodex.

For the Consumer

Applies to ciprofloxacin / dexamethasone otic: otic suspension

In addition to its needed effects, some unwanted effects may be caused by ciprofloxacin / dexamethasone otic. In the event that any of these side effects do occur, they may require medical attention.

Minor Side Effects

Some of the side effects that can occur with ciprofloxacin / dexamethasone otic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Ear discomfort
  • ear pain
  • itching skin on the ear
  • Bitter, sour or unusual taste in mouth
  • ear congestion
  • ear debris
  • ear residue
  • redness of skin
  • superimposed ear infection (second ear infection)

For Healthcare Professionals

Applies to ciprofloxacin / dexamethasone otic: otic suspension


Local side effects in patients with intact tympanic membranes have included ear pruritus (1.5%), ear debris (0.6%), superimposed ear infection (0.6%), ear congestion (0.4%), ear pain (0.4%), ear discomfort, decreased hearing, and tingling. Ear discomfort (3%), ear pain (2.3%), and ear residue (0.5%), tube blockage, tinnitus, and ear pruritus have been reported in pediatric patients with tympanostomy tubes.[Ref]


Gastrointestinal side effects have included taste perversion and oral moniliasis.[Ref]

Nervous system

Nervous system side effects have included dizziness and irritability.[Ref]


Dermatologic side effects have included erythema.[Ref]


Other side effects in patients with tympanostomy tubes have included crying.[Ref]


1. "Product Information. Ciprodex (ciprofloxacin-dexamethasone otic)." Alcon Laboratories Inc, Fort Worth, TX.

Not all side effects for Ciprodex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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