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Ciprodex Side Effects

Generic name: ciprofloxacin / dexamethasone otic

Medically reviewed by Last updated on Nov 28, 2023.

Note: This document contains side effect information about ciprofloxacin / dexamethasone otic. Some dosage forms listed on this page may not apply to the brand name Ciprodex.

Applies to ciprofloxacin/dexamethasone otic: otic suspension.

Serious side effects of Ciprodex

Along with its needed effects, ciprofloxacin/dexamethasone otic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ciprofloxacin / dexamethasone otic:

Incidence not known

Other side effects of Ciprodex

Some side effects of ciprofloxacin / dexamethasone otic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


For Healthcare Professionals

Applies to ciprofloxacin / dexamethasone otic: otic suspension.


The most commonly reported side effects in patients with tympanostomy tubes and acute otitis media were ear pain, discomfort, and dysgeusia/tasting medicine.

The most commonly reported side effect in patients with acute otitis externa was ear pruritus.[Ref]


Common (1% to 10%): Ear discomfort, ear pain, ear pruritus

Uncommon (0.1% to 1%): Otorrhea, fatigue, ear congestion, candidiasis/fungal ear infection, crying, superimposed ear infection, device/tympanostomy tube blockage/occlusion, ear precipitate/residue/debris/medication residue present

Rare (0.01% to 0.1%): Hypoacusis, tinnitus

Frequency not reported: decreased hearing, ear disorder

Postmarketing reports: Auricular swelling[Ref]

Nervous system

Uncommon (0.1% to 1%): Taste perversion/dysgeusia, paresthesia/tingling in ears

Rare (0.01% to 0.1%): Dizziness, headache[Ref]


Uncommon (0.1% to 1%): Erythema, flushing

Rare (0.01% to 0.1%): Rash erythematous

Postmarketing reports: Skin exfoliation[Ref]


Uncommon (0.1% to 1%): Vomiting

Frequency not reported: Oral moniliasis[Ref]


Uncommon (0.1% to 1%): Irritability[Ref]


Postmarketing reports: Hypersensitivity[Ref]


1. (2003) "Product Information. Ciprodex (ciprofloxacin-dexamethasone otic)." Alcon Laboratories Inc

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.