Cinryze Side Effects

Generic name: C1 esterase inhibitor (human)

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 21, 2025.

Note: This document provides detailed information about Cinryze Side Effects associated with C1 esterase inhibitor (human). Some dosage forms listed on this page may not apply specifically to the brand name Cinryze.

Applies to C1 esterase inhibitor (human): intravenous powder for solution.

Other dosage forms:

• powder for solution

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.

HAE attacks are life-threatening and require immediate medical attention. Check with your doctor right away, or go to an emergency room as soon as possible, even if you feel better after using this medicine.

This medicine may cause serious allergic reactions. These reactions can be life-threatening and require immediate medical attention. Call your doctor or nurse right away if you have a rash, itching, hives, hoarseness, chest tightness, lightheadedness, dizziness or fainting, shortness of breath, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive this medicine.

This medicine may increase your risk of developing blood clots. Check with your doctor right away if you have swelling and pain in your arms, legs, or stomach, chest pain, shortness of breath, loss of sensation, confusion, or problems with muscle control or speech.

Common side effects of Cinryze

Some side effects of C1 esterase inhibitor (human) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Cinryze

Along with its needed effects, C1 esterase inhibitor (human) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking C1 esterase inhibitor (human):

For healthcare professionals

Applies to C1 esterase inhibitor (human): intravenous kit, intravenous powder for injection, subcutaneous powder for injection.

Respiratory adverse events

Respiratory side effects have included sinusitis, bronchitis, upper respiratory tract infection, and viral upper respiratory tract infection.^[Ref]

Nervous system

Nervous system side effects have included headache.^[Ref]

Musculoskeletal

Musculoskeletal side effects have included limb injury, back pain, and pain in extremity.^[Ref]

Dermatologic

Dermatologic side effects have included pruritus.^[Ref]

Cardiovascular

Cardiovascular side effects have included postmarketing reports of thrombotic events including deep vein thrombosis, myocardial infarction, and transient ischemic attack.^[Ref]

See also:

Frequently asked questions

• What is Cinryze used for and how does it work?
• What is Ruconest used for and how does it work?
• How is Berinert administered?
• How does Berinert work for Hereditary Angioedema (HAE)?

Further information

Cinryze side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer