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Cinryze Side Effects

Generic name: C1 esterase inhibitor (human)

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 19, 2024.

Note: This document provides detailed information about Cinryze Side Effects associated with C1 esterase inhibitor (human). Some dosage forms listed on this page may not apply specifically to the brand name Cinryze.

Applies to C1 esterase inhibitor (human): intravenous powder for solution.

Other dosage forms:

Common side effects of Cinryze

Some side effects of C1 esterase inhibitor (human) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

Less common side effects

  • back pain
  • burning sensation on the skin
  • diarrhea
  • feeling of constant movement of self or surroundings
  • nausea
  • sensation of spinning
  • sneezing

Incidence not known

  • abdominal or stomach pain

Serious side effects of Cinryze

Along with its needed effects, C1 esterase inhibitor (human) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking C1 esterase inhibitor (human):

Less common side effects

  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Incidence not known

  • cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, or skin rash
  • pains in the chest, groin, or legs, especially calves of the legs
  • severe headaches of sudden onset
  • shortness of breath
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
  • tightness in the chest
  • unusual tiredness or weakness
Managing side effects (general information)

For healthcare professionals

Applies to C1 esterase inhibitor (human): intravenous kit, intravenous powder for injection, subcutaneous powder for injection.

Respiratory adverse events

Respiratory side effects have included sinusitis, bronchitis, upper respiratory tract infection, and viral upper respiratory tract infection.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]

Musculoskeletal

Musculoskeletal side effects have included limb injury, back pain, and pain in extremity.[Ref]

Dermatologic

Dermatologic side effects have included pruritus.[Ref]

Cardiovascular

Cardiovascular side effects have included postmarketing reports of thrombotic events including deep vein thrombosis, myocardial infarction, and transient ischemic attack.[Ref]

References

1. (2022) "Product Information. Cinryze (C1 esterase inhibitor, human)." ViroPharma Incorporated

2. Gandhi PK, Gentry WM, Bottorff MB (2012) "Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database." Pharmacotherapy, 32, p. 902-9

Frequently asked questions

Further information

Cinryze side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer