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Cinryze Side Effects

Generic Name: C1 esterase inhibitor (human)

Note: This document contains side effect information about C1 esterase inhibitor (human). Some of the dosage forms listed on this page may not apply to the brand name Cinryze.

For the Consumer

Applies to C1 esterase inhibitor (human): intravenous powder for solution

Along with its needed effects, C1 esterase inhibitor (human) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking C1 esterase inhibitor (human):

More common
  • Chest pain
  • head congestion
  • hoarseness or other voice changes
  • nausea and vomiting
  • pain or tenderness around the eyes and cheekbones
  • rash
  • sore throat
  • tightness of the chest
  • trouble breathing
Less common
  • Flushing or redness of the skin
  • itching
  • unusually warm skin
Incidence not known
  • Confusion
  • difficulty with speaking
  • difficulty with swallowing
  • dizziness
  • double vision
  • fast heartbeat
  • general tiredness and weakness
  • hives
  • inability to move the arms, legs, or facial muscles
  • numbness or tingling in the face, arms, or legs
  • pain, redness, or swelling in the arm or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • slow speech
  • trouble speaking, thinking, or walking

Some side effects of C1 esterase inhibitor (human) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • headache
  • pain
  • stomach pain
Less common
  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • change in taste
  • fever
  • loss of taste
  • muscle aches
  • pain at the catheter site
  • stuffy or runny nose
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to C1 esterase inhibitor (human): intravenous kit, intravenous powder for injection


Respiratory side effects have included sinusitis, bronchitis, upper respiratory tract infection, and viral upper respiratory tract infection.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]


Musculoskeletal side effects have included limb injury, back pain, and pain in extremity.[Ref]


Dermatologic side effects have included pruritus.[Ref]


Cardiovascular side effects have included postmarketing reports of thrombotic events including deep vein thrombosis, myocardial infarction, and transient ischemic attack.[Ref]


1. "Product Information. Cinryze (complement C1 esterase inhibitor)." ViroPharma Incorporated, Exton, PA.

2. Gandhi PK, Gentry WM, Bottorff MB "Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database." Pharmacotherapy 32 (2012): 902-9

Some side effects of Cinryze may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.