Caffeine Side Effects
More frequently reported side effects include: necrotizing enterocolitis. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to caffeine: oral solution, oral tablet
Other dosage forms:
Side effects requiring immediate medical attention
Along with its needed effects, caffeine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking caffeine:
- Feeding intolerance
- black, tarry stools
- blood in the stools or urine
- burning feeling or tenderness in the stomach
- coughing or vomiting blood
- decreased urine output
- fast heartbeat
- muscle twitching
- persistent bleeding
- rapid, shallow breathing
- rapid weight gain
- severe stomach pain
- stomach upset
- swelling of the face, ankles, or hands
- trouble breathing
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
Get emergency help immediately if any of the following symptoms of overdose occur while taking caffeine:
Symptoms of overdose
- rapid heartbeat
- trouble sleeping
Side effects not requiring immediate medical attention
Some side effects of caffeine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to caffeine: compounding powder, intravenous solution, oral gum, oral liquid, oral tablet, oral tablet dispersible, oral tablet extended release
Very common (10% or more): Constipation (up to 17.4%)
Frequency not reported: Increased gastric aspirate, GI intolerance, vomiting, regurgitation[Ref]
Long-term follow-up studies have not shown caffeine to adversely affect neurological development or growth parameters.[Ref]
Common (1% to 10%): Hemorrhage, tachycardia
Uncommon (0.1% to 1%): Arrhythmia
Frequency not reported: Increased left ventricular output, increased stroke volume, hypertension[Ref]
Common (1% to 10%): Rash, dry skin, skin breakdown[Ref]
Common (1% to 10%): Disseminated intravascular coagulation, anemia
Frequency not reported: Decreased hemoglobin[Ref]
Common (1% to 10%): Acidosis, hyperglycemia
Common (1% to 10%): Cerebral hemorrhage
Uncommon (0.1% to 1%): Convulsions/seizures
Common (1% to 10%): Perinatal disorder (trace aspirates, feeding intolerances), injection site reaction, sepsis, accidental injury, abnormal healing, infusion site phlebitis and inflammation
Frequency not reported: Failure to thrive, deafness[Ref]
Frequency not reported: Tachypnea[Ref]
Rare (less than 0.1%): Hypersensitivity reaction[Ref]
Frequency not reported: Increased urine flow rate, increased creatinine clearance, increased sodium and calcium excretion[Ref]
1. "Product Information. Cafcit (caffeine)" Roxane Laboratories Inc, Columbus, OH.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
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